Patents by Inventor Jefffrey S. Lin

Jefffrey S. Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System for determining drug resistance in microorganisms
    Patent number: 9353396
    Abstract: The present invention is based on the discovery that drug resistance in microorganisms can be rapidly and accurately determined using mass spectrometry. A mass spectrum of an intact microorganism or one or more isolated biomarkers from the microorganism grown in drug containing, isotopically-labeled media is compared with a mass spectrum of the intact microorganism or one or more isolated biomarkers from the microorganism grown in non-labeled media without the drug present. Drug resistance is determined by predicting and detecting a characteristic mass shift of one or more biomarkers using algorithms. The characteristic mass shift is indicative that the microorganism is growing in the presence of the drug and incorporating the isotopic label into the one or more biomarkers, resulting in change in mass.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: May 31, 2016
    Assignee: The Johns Hopkins University
    Inventors: Plamen A. Demirev, Nathan A. Hagan, Miquel D. Antoine, Jefffrey S. Lin, Andrew B. Feldman
  • SYSTEM FOR DETERMINING DRUG RESISTANCE IN MICROORGANISMS
    Publication number: 20130288356
    Abstract: The present invention is based on the discovery that drug resistance in microorganisms can be rapidly and accurately determined using mass spectrometry. A mass spectrum of an intact microorganism or one or more isolated biomarkers from the microorganism grown in drug containing, isotopically-labeled media is compared with a mass spectrum of the intact microorganism or one or more isolated biomarkers from the microorganism grown in non-labeled media without the drug present. Drug resistance is determined by predicting and detecting a characteristic mass shift of one or more biomarkers using algorithms. The characteristic mass shift is indicative that the microorganism is growing in the presence of the drug and incorporating the isotopic label into the one or more biomarkers, resulting in change in mass.
    Type: Application
    Filed: June 24, 2013
    Publication date: October 31, 2013
    Inventors: Plamen A. Demirev, Nathan A. Hagan, Miquel D. Antoine, Jefffrey S. Lin, Andrew B. Feldman