Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Abstract: Methods for continuously inactivating a virus during manufacture of a protein are provided. Steps include (1) combining, at a single predetermined volumetric ratio, a composition including the protein, and a composition including a virus-inactivation reagent, to obtain a treatment composition having a predetermined property for inactivation of a virus; (2) transferring the treatment composition to a treatment vessel; (3) incubating the treatment composition in the treatment vessel at predetermined conditions; and (4) subjecting the treatment composition to a post-treatment processing operation. The single predetermined volumetric ratio has been selected to ensure that the predetermined property of the treatment composition is maintained across a range of concentrations predicted for the protein in the composition including the protein.

Abstract: An apparatus including a policy acquisition circuit, a parameter acquisition circuit, and a parameter storage circuit. The policy acquisition circuit interprets a vehicle policy data value having at least one requested vehicle property. The parameter acquisition circuit interprets vehicle parameter values from providing end points each on at least one network zone of a vehicle. The parameter storage circuit selectively stores a portion of the vehicle parameter values. A first portion of the stored portion of the vehicle parameter values is stored on a storage end point distinct from an associated one of the providing end points for the at least a first portion of the stored vehicle parameter values. The parameter storage circuit also determines a reserved memory amount by determining an amount of data to be collected to support the at least a portion of the vehicle parameter values.

Abstract: Windshields are disclosed herein having an optical path, that include an inner rigid substrate, optically adjacent a first wedge polymer layer, that serves to reflect a primary image. A reflective layer is also provided, positioned in the optical path between the first wedge polymer layer and a second wedge polymer layer. The windshields are further provided with an outer rigid substrate, optically adjacent the second wedge polymer layer. The first wedge polymer layer causes visible light reflected from the reflective layer to overlap the primary image, and the second wedge polymer layer causes visible light reflected from an outer face of the outer rigid substrate to overlap the primary image.

Abstract: Ion-pairs known as GUMBOS (group of uniform materials based on organic salts) from antiseptics (chlorhexidine and octenidine) and the beta-lactam antibiotic, ceftriaxone. The antimicrobial efficacy of these GUMBOS and unreacted stoichiometric equivalent mixtures were compared to ceftriaxone and azithromycin alone. On a molar basis, GUMBOS were equivalent to ceftriaxone and 10× more effective in killing N. gonorrhoeae than azithromycin. They were more than 100× more effective than either antibiotic in killing CRE. A strategy involving the electrostatic interaction between a common antiseptic and a discontinued antibiotic (octenidine and carbenicillin) was also evaluated as a treatment for gonorrhoea. Octenidine/carbenicillin is a novel group of uniform materials based on organic salts (GUMBOS) with inherent in vitro antibacterial activity that comes from its parent antiseptic and antibacterial ions, octenidine and carbenicillin, respectively.

Abstract: Operations include storing and/or accessing data in tape volume containers. A system receives a request to access a tape block in a data storage tape. The system maps the requested tape block in the data storage tape to an object in a container. The system then retrieves data from the object in the container. The system generates, from the retrieved data, a data stream in tape archive format. The system transmits the data stream, in tape archive format, in response to the request to access the tape block in the data storage tape.

Abstract: Operations include storing and/or accessing data in tape volume containers. A system receives a request to access a tape block in a data storage tape. The system maps the requested tape block in the data storage tape to an object in a container. The system then retrieves data from the object in the container. The system generates, from the retrieved data, a data stream in tape archive format. The system transmits the data stream, in tape archive format, in response to the request to access the tape block in the data storage tape.

Abstract: A continuous data protection system, and associated method, for point-in-time data recovery. The system includes a consistency group of data volumes. A support processor manages a journal of changes to the set of volumes and stores meta-data for the volumes. A storage processor processes write requests by: determining if the write request is for a data volume in the consistency group; notifying the support processor of the write request including providing data volume meta-data; and storing modifications to the data volume in a journal. The support processor receives a data restoration request including identification of the consistency group and a time for data restoration. The support processor uses the data volume meta-data to reconstruct a logical block map of the data volume at the requested time and directs the storage processor to make a copy of the data volume and map changed blocks from the journal into the copy.

Abstract: A continuous data protection system, and associated method, for point-in-time data recovery. The system includes a consistency group of data volumes. A support processor manages a journal of changes to the set of volumes and stores meta-data for the volumes. A storage processor processes write requests by: determining if the write request is for a data volume in the consistency group; notifying the support processor of the write request including providing data volume meta-data; and storing modifications to the data volume in a journal. The support processor receives a data restoration request including identification of the consistency group and a time for data restoration. The support processor uses the data volume meta-data to reconstruct a logical block map of the data volume at the requested time and directs the storage processor to make a copy of the data volume and map changed blocks from the journal into the copy.

Abstract: The invention transforms source data from a source platform to a target platform with a single copy. A data request signal is communicated from the target platform to the source platform and a location of the source data is determined in a disk subsystem supporting snapshot. The disk subsystem (i.e., a snapshot facility) copies the source data in raw form to one or more target disks designated by the target platform. The locations of the source data and the target disks are communicated to the target platform and the source data is read from the disk subsystem to transform the data to the target platform. The process starts from a request of an application resident within the target platform. One or more data management units can be used to determine source and target disk locations. Preferably, the source platform also communicates metadata to the target platform; and thus metadata, when available, is also copied via snapshot operations in the disk subsystem.