Patents by Inventor Jeffrey A. Coderre

Jeffrey A. Coderre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for improvement of radiation therapy of malignant tumors
    Patent number: 6299873
    Abstract: A method of optimizing malignancy therapy includes surgical removal or reduction of the body burden of malignant cells and retention of some of those cells for subsequent use in immunotherapy. Boron neutron-capture therapy is employed at a radiation dosage below the threshold for normal tissue necrosis to provide preservation of normal tissue structure. Normal tissue tolerable limits are in the range of 10-13 GY-Eq. The removed tumor cells are altered by radiation or genetically to render them incapable of unlimited clonogenic propagation and then reinjected using multiple sequenced injections.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: October 9, 2001
    Assignee: University of Connecticut
    Inventors: Henry M. Smilowitz, Jeffrey A. Coderre, Daniel N. Slatkin
  • Boron containing amino acid compounds and methods for their use
    Patent number: 6017902
    Abstract: The present invention provides new boron containing amino acid compounds and methods for making these compounds by contacting melphalan or another nitrogen mustard derivative and sodium borocaptate. The present invention also provides a method of treating a mammal having a tumor by administering to the mammal a therapeutically effective amount of the new boron containing amino acid compounds.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: January 25, 2000
    Assignee: Brookhaven Science Associates
    Inventors: John D. Glass, Jeffrey A. Coderre