Abstract: An exemplary computing device includes a plurality of circuits and/or a plurality of in-situ monitors configured to generate outputs that indicate one or more operating conditions of the circuits. The computing device also includes a system management unit configured to detect a potentially faulty voltage-to-frequency ratio implemented by one of the circuits based at least in part on one or more of the outputs. The system management unit is also configured to modify the potentially faulty voltage-to-frequency ratio based at least in part on one or more of the outputs. Various other devices, systems, and methods are also disclosed.

Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to the compound of formula (I): having the name 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and tautomers thereof.

Abstract: Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-?. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.

Abstract: Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-?. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.

Abstract: Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-?. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.

Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.

Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.

Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to the Compound for formula 1: having the name 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4 -dihydropyrazino[2,3-b]pyrazin-2(1H)-one and tautomers thereof.

Abstract: Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-?. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.

Abstract: Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-?. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.

Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.

Abstract: Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.

Abstract: An archery bowstring release includes a string grip for holding and releasing a bowstring, and a band for mounting the string grip about an archer's wrist or hand. The string grip may rotate about the band between an in-use position wherein the string grip is adjacent the archer's fingers, and a stowed position situated away from the archer's hand. This rotating arrangement is biased such that the string grip resists being situated in other than the in-use and stowed positions. Thus, the archer may “snap” the string grip into the in-use position when the string grip is desired for use in shooting, and may “snap” the string grip to the stowed position when the string grip is not needed. In this manner, the string grip does not interfere with use of the archer's hand when it is not in use.

Abstract: An arrowhead of the expandable or mechanical broadhead type, i.e., having blades which unfold to increase the effective cutting area of the arrowhead, includes a tip with a rearwardly-extending actuating member which triggers one or more blades into an open state when the tip strikes a target game animal. The blades are pivotable with respect to a body into which the actuating member extends, and they include ears against which the actuating member presses upon tip impact to trigger the blades open. A latching spring maintains the blades in a closed state until the tip and actuating member are driven rearwardly by tip impact, and the tip and actuating member are preferably maintained in a forward and ready-to-trigger state by an opening spring. The actuating member may extend between the blade ears after the blades are triggered open to fix the blades in the open state until the tip is pulled forwardly to withdraw the actuating member from the ears.

Abstract: A string release for providing accurate release of a tensioned bow string. The release has a pair of jaws which are retained and controlled by a pivot ball and a jaw cup. The pivot ball being mounted on a shaft which is attached to an inner race which is in turn contained within a ball housing. The inner race is positioned such that it may slide laterally within the ball housing. In the closed position, a number of balls retain the inner race in an aft position relative to the jaws. A trigger mechanism actuates a locking sleeve which allows the balls to move such that the inner race may slide forward, thereby allowing the jaw to open. The release further includes a trigger force adjusting mechanism that allows adjustment of the force required to activate the trigger mechanism.

Abstract: An adjustable trigger pressure archery release including a bayonet mounted trigger utilizing an actuator ramp to reduce trigger travel. The caliper jaws and cam profile combine to create an automatic closing action to close the release, whereby rearward pulling or squeezing movement of the trigger engages the caliper jaws to an open bow string or string loop apparatus receiving condition, and relaxing or releasing movement of the trigger closes the caliper jaws into a string retaining position. The release includes an independent mechanism for permitting adjustment of the trigger pressure force, without affecting trigger travel including frictional means of maintaining selected setting. The release head is universally adjustable or lockable relative to a wrist strap or similar mounting.

Abstract: An adjustable trigger pressure archery release including a bayonet mounted trigger utilizing an actuator ramp to reduce trigger travel. The caliper jaws and cam profile combine to create an automatic closing action to close the release, whereby rearward pulling or squeezing movement of the trigger engages the caliper jaws to an open bow string or string loop apparatus receiving condition, and relaxing or releasing movement of the trigger closes the caliper jaws into a string retaining position. The release includes an independent mechanism for permitting adjustment of the trigger pressure force, without affecting trigger travel including frictional means of maintaining selected setting. The release head is universally adjustable or lockable relative to a wrist strap or similar mounting.

Abstract: A bow string release for engaging and releasing a bow string, comprising opposing jaws, a trigger, a housing, a jaw roller and a plurality of pins, the opposing jaws and the trigger coupled to the housing by pins, and the jaw roller coupled to the trigger and allowing the opposing jaws to an open condition when the trigger is in a pulled position. The bow string release of the present invention is adapted to minimize “loading up” of trigger force required to pull the trigger at full draw of a bow. Further the bow string release of the present invention is adapted to release the bow string at a trigger pull force of equal to or less than 9 ounces when an effective draw weight of the bow is equal to or more than 15 pounds.

Abstract: A bow string release for engaging and releasing a bow string, comprising opposing jaws, a trigger, a housing, a jaw roller and a plurality of pins, the opposing jaws and the trigger coupled to the housing by pins, and the jaw roller coupled to the trigger and allowing the opposing jaws to an open condition when the trigger is in a pulled position. The bow string release of the present invention is adapted to minimize “loading up” of trigger force required to pull the trigger at full draw of a bow. Further the bow string release of the present invention is adapted to release the bow string at a trigger pull force of equal to or less than 9 ounces when an effective draw weight of the bow is equal to or more than 15 pounds.

Abstract: A string release for providing accurate release of a tensioned bow string. The release has a pair of jaws which are retained and controlled by a pivot ball and a jaw cup. the pivot ball being mounted on a shaft which is attached to an inner race which is in turn contained within a ball housing. The inner race is positioned such that it may slide laterally within the ball housing. In the closed position, a number of balls retain the inner race in an aft position relative to the jaws. A trigger mechanism actuates a locking sleeve which allows the balls to move such that the inner race may slide forward, thereby allowing the jaw to open. The release further includes a trigger force adjusting mechanism that allows adjustment of the force required to activate the trigger mechanism.