Abstract: An electrochemical additive manufacturing method includes positioning a build plate into an electrolyte solution. The conductive layer comprises at least one conductive-layer segment forming a pattern corresponding with a component. The method further comprises connecting the at least one conductive-layer segment and one or more deposition anodes to a power source. The one or more deposition anodes correspond with at least a portion of the pattern formed by the at least one conductive-layer segment. The method additionally comprises transmitting electrical energy from the power source through the one or more deposition anodes of the plurality of deposition anodes corresponding with the at least the portion of the pattern formed by the at least one conductive-layer segment, through the electrolyte solution, and to the at least one conductive-layer segment, such that material is deposited onto the at least one conductive-layer segment and forms at least a portion of the component.

Abstract: Biomarkers of kidney function and methods for using said biomarkers for assessing kidney function, monitoring kidney function, diagnosing acute kidney injury, and diagnosing chronic kidney disease are provided. Also provided are suites of small molecule entities as biomarkers for chronic kidney disease.

Abstract: Biomarkers relating to insulin resistance and insulin resistance-related disorders are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, dysglycemia, type-2 diabetes, and cardiovascular disease. In addition, methods for monitoring the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, dysglycemia, type-2 diabetes, and cardiovascular disease.

Abstract: An apparatus and method are shown for fileting fish. The apparatus includes a retaining pan and a pair of support elements capable of spanning the width of the pan interior by attachment to the opposing outer edges of the pan. The support elements have retaining elements which are used to securely affix a cutting board to the support elements. Once assembled, the cutting board creates an ideal location to filet a fish while allowing the fluids discharged from the fish to flow over the edges of the board and collect into the surrounding retaining pan.

Abstract: An apparatus and method are shown for filleting fish. The apparatus includes a retaining pan and a pair of support elements capable of spanning the width of the pan interior by attachment to the opposing outer edges of the pan. The support elements have retaining elements which are used to securely affix a cutting board to the support elements. Once assembled, the cutting board creates an ideal location to filet a fish while allowing the fluids discharged from the fish to flow over the edges of the board and collect into the surrounding retaining pan.

Abstract: An apparatus and method are shown for fileting fish. The apparatus includes a retaining pan and a pair of support elements capable of spanning the width of the pan interior by attachment to the opposing outer edges of the pan. The support elements have retaining elements which are used to securely afix a cutting board to the support elements. Once assembled, the cutting board creates an ideal location to filet a fish while allowing the fluids discharged from the fish to flow over the edges of the board and collect into the surrounding retaining pan.

Abstract: The present invention provides a method and apparatus for physiological monitoring of a remote subject, the apparatus including: a base station having a transmission means for transmitting a reference signal; and a physiological monitoring probe connectable to the subject, the physiological monitoring probe having: receiver means for receiving the reference signal; monitoring means for monitoring the subject and generating a condition signal containing information related to a condition of the subject; modulation means for modulating the reference signal to produce a modulated reference signal containing the information contained in the condition signal; and passive retransmission means for passively retransmitting the modulated reference signal to the base station; wherein the base station has means for receiving the modulated reference signal, and means for demodulating the modulated reference signal to obtain the information related to a condition of the subject so that a condition of the subject can be mo

Abstract: A method is disclosed for rational design of a PPAR, FXR, LXR-alpha, or LXR-beta antagonist comprising chemical modification of a PPAR, FXR, LXR-alpha, or LXR-beta agonist to: a) prevent formation of a hydrogen bond between the agonist and tyrosine or histidine, or tryptophan involved in receptor activation; and/or b) displace the tyrosine or histidine, or tryptophan involved in receptor activation from its agonist bound position. Preferably, little or no additional changes are made in the structure of the agonist so that the resulting antagonist is a close structural analogue of the agonist.

Abstract: A compound having formula (I), wherein A is selected from the group consisting of: (i) phenyl, wherein said phenyl is optionally substituted by one or more halogen atoms, C1-6alkyl, C1-3alkoxy, C1-3fluoroalkoxy, nitrile, or —NR7R8 where R7 and R8 are independently hydrogen or C1-3alkyl; (ii) a 5- or 6-membered hetrocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur; and (iii) a fused bicyclic ring (a), wherein ring C represents a heterocyclic group as defined in point (ii) above, which bicyclic ring is attached to group B via a ring atom of ring C; B is selected from the group consisting of: (iv) C1-6alkylene; (v) —MC1-6alkylene or C1-6alkyleneMC1-6alkylene, wherein M is O, S, or —NR2 wherein R2 represents hydrogen or C1-3alkyl; (vi) a 5- or 6-membered heterocyclic group containing at least one nitrogen heteroatom and optionally at least one further heteroatom selected from oxygen, nitrogen and sulfur and optionally substituted by C1-3alkyl; and (vii) H

Abstract: A data distribution system has a number of data processing devices interconnected by data transmission media. At least one of the data processing devices transmit data to other data processing devices in the system. The transmitting data processing system includes memory for storing the data to be transmitted, programmable data processing circuitry, and data transmission apparatus for transmitting an encoded representation of the stored message as a sequence of data packets. Priority data, stored in the memory, represents a plurality of assigned priority levels for specified portions of the stored message such that portions of the stored message have respective assigned priority levels. A data encoding program generates an encoded representation of the stored message that includes, for each portion of the stored message, a level of redundant data corresponding to the priority level assigned to that portion of the stored message.