Abstract: An implantable device for intratumoral delivery of a therapeutic agent is provided. The implantable device includes a polymer matrix within which is dispersed a pharmaceutical formulation that includes one or more therapeutic agents. The therapeutic agent(s) includes one or more antibodies. Optionally, the polymer matrix includes one or more excipients. The polymer matrix includes a hydrophobic polymer. The hydrophobic polymer has a melt flow index of from about 0.2 to about 100 grams per 10 minutes as determined in accordance with ASTM D1238-20 at a temperature of 190° C. and a load of 2.16 kilograms and/or a melting temperature of from about 20° C. to about 70° C. as determined in accordance with ASTM D3418-21.

Abstract: Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.

Abstract: An implantable medical device is provided. The core includes a core polymer matrix within which is dispersed a therapeutic agent comprising one or more antipsychotics. The core polymer matrix contains an ethylene vinyl acetate copolymer. The ethylene vinyl acetate copolymer has a melt flow index of about 1 to about 400 grams per 10 minutes as determined in accordance with ASTM D1238-20 at a temperature of 190° C. and a load of 2.16 kilograms.

Abstract: An implantable medical device is provided. The core includes a core polymer matrix within which is dispersed a therapeutic agent comprising one or more aromatase inhibitors. The core polymer matrix contains an ethylene vinyl acetate copolymer. The ethylene vinyl acetate copolymer has a melting temperature of from about 40° C. to about 120° C. as determined in accordance with ASTM D3418-15.

Abstract: An intravaginal ring device is provided. The core includes a core polymer matrix within which is dispersed a therapeutic agent comprising one or more aromatase inhibitors. The core polymer matrix contains an ethylene vinyl acetate copolymer. The ethylene vinyl acetate copolymer has a vinyl acetate content of from about 10 wt. % to about 60 wt. % and/or a melting temperature of from about 40° C. to about 120° C. as determined in accordance with ASTM D3418-15.

Abstract: An implantable and refillable device for delivering a drug compound is provided. The device comprises a reservoir within which the drug compound is capable of being retained, wherein the reservoir defines a first surface and a second surface opposing the first surface. A release structure comprising a hydrophobic polymer surrounds at least a portion of the reservoir. The release structure is in communication with the reservoir such that the drug compound can pass from the reservoir through the release structure. A septum is positioned adjacent to the first surface of the reservoir and a backing layer is positioned adjacent to the second surface of the reservoir.

Abstract: An oral adhering lozenge is provided which delivers to the mouth a component with an undesirable flavor and a component for delivering a masking flavor. The oral adhering lozenge comprises a first, adherent layer and a second layer. The first, adherent layer includes a flavor-masking component, and the second layer includes both an active component and a flavor-masking component. In another configuration, the first, adherent layer includes both an active component and a flavor-masking component. In use, the second layer of the lozenge generally finishes dissolving and/or eroding in the mouth before the first layer finishes dissolving and/or eroding. The later eroding adherent layer will continue to release the flavor-masking component after all of the active component has been released into the mouth, thereby providing increased masking of any bitter aftertaste of the active.

Abstract: An implantable and refillable device for delivering a contraceptive agent is provided. The device comprises a reservoir within which the contraceptive agent is capable of being retained, wherein the reservoir defines a first surface and a second surface opposing the first surface. A release structure comprising a hydrophobic polymer surrounds at least a portion of the reservoir. The release structure is in communication with the reservoir such that the contraceptive agent can pass from the reservoir through the release structure. A septum is positioned adjacent to the first surface of the reservoir and a backing layer is positioned adjacent to the second surface of the reservoir.

Abstract: An oral adhering lozenge is provided which delivers to the mouth a component with an undesirable flavor and a component for delivering a masking flavor. The oral adhering lozenge comprises a first, adherent layer and a second layer. The first, adherent layer includes a flavor-masking component, and the second layer includes both an active component and a flavor-masking component. In another configuration, the first, adherent layer includes both an active component and a flavor-masking component. In use, the second layer of the lozenge generally finishes dissolving and/or eroding in the mouth before the first layer finishes dissolving and/or eroding. The later eroding adherent layer will continue to release the flavor-masking component after all of the active component has been released into the mouth, thereby providing increased masking of any bitter aftertaste of the active.

Abstract: A system for detecting when two people are in a vehicle. The system detects the presence of two warm bodies with one or two infrared cameras.

Abstract: A system for detecting when two people are in a vehicle. The system detects the presence of two warm bodies with one or two infrared cameras.

Abstract: A multi-layer film or laminate is disclosed in which an olefinic polymer layer is adhered to a metal foil layer without the use of an adhesive. The olefinic polymer layer contains an olefinic polymer in combination with a transition metal salt. The addition of the transition metal salt greatly improves the peel strength of the laminate.

Abstract: A system for reducing traffic accidents caused by distraction from a mobile telecom device. The system detects when the device is near a driver's seat of a moving vehicle. While the system is carrying a voice call between a remote voice device and the mobile device, the system modifies voice signal transmission between the devices by periodically playing a beep or other signal to remind the parties that one of them is driving and suspends voice signal transmission from the remote device to the mobile device when the system detects that circumstances affecting level of attention required for driving merit the driver paying greater attention.

Abstract: A troche comprising at least 5 mg hyaluronan, wherein the troche is adherent, and wherein hyaluronan is released from the troche, is used to treat mucositis, including stomatitis, vestibulitis, aphthous ulcerations, lichen planus and Behcet's syndrome. A method for treating or preventing mucositis in a patient is provided, comprising applying to a mucosal surface or a tooth or orthodontic brace of a patient in need thereof an adhering troche comprising at least 5 mg hyaluronan.

Abstract: An embodiment combines the concepts of image enhancement and pointing to enhance the experience of viewing images by tracking where the viewer is pointing. The result is to make the viewing experience more like viewing the original scene, or to enhance the viewing experience in new ways beyond the original experience, either automatically, or by interacting with a photographer's previously specified intentions for what should happen when the viewer points at a particular portion of an image or images taken by that photographer.

Abstract: An embodiment combines the concepts of image enhancement and gaze tracking to enhance the experience of viewing images by tracking where the viewer is looking. The result is to make the viewing experience more like viewing the original scene, or to enhance the viewing experience in new ways beyond the original experience, either automatically, or by interacting with a photographer's previously specified intentions for what should happen when the viewer looks at a particular portion of an image or images taken by that photographer.

Abstract: A system for reducing traffic accidents caused by distraction from a mobile telecom device. The system detects when the device is near a driver's seat of a moving vehicle. While the system is carrying a voice call between a remote voice device and the mobile device, the system modifies voice signal transmission between the devices by periodically playing a beep or other signal to remind the parties that one of them is driving and suspends voice signal transmission from the remote device to the mobile device when the system detects that circumstances affecting level of attention required for driving merit the driver paying greater attention.

Abstract: A troche comprising at least 5 mg hyaluronan, wherein the troche is adherent, and wherein hyaluronan is released from the troche, is used to treat mucositis, including stomatitis, vestibulitis, aphthous ulcerations, lichen planus and Behcet's syndrome. A method for treating or preventing mucositis in a patient is provided, comprising applying to a mucosal surface or a tooth or orthodontic brace of a patient in need thereof an adhering troche comprising at least 5 mg hyaluronan.

Abstract: This invention is directed to a superior adhesive for oral adhering discs or troches. The adhesive is at least 80% acacia gum mixed with calcium carbonate so that, as the acacia gum is combined with water, it does not yield a pH lower than 5.5. The preferred ratio of acacia gum to calcium carbonate is within the range 15:1 to 50:1.

Abstract: A system for reducing traffic accidents caused by distraction from a mobile telecom device. The system detects when the device is near a driver's seat of a moving vehicle. When the network receives a call from a caller directed to a called person associated with the mobile telecom device, the system plays a message to the caller stating that the called person is driving and asking whether the call is important enough to put through. If the caller provides an affirmative response, the system puts the call through to the telecom device, and if the caller provides a negative response or no response, the system does not put the call through.