Abstract: A glaucoma shunt device is provided for draining a biological fluid from an eye. The glaucoma shunt device includes a primary tube, a secondary tube, and a shunt body. The primary tube has a primary proximal end, a primary distal end, and a primary conduit extending therebetween. The secondary tube has a secondary proximal end, a secondary distal end, and a secondary conduit extending therebetween. The secondary tube is at least partially inserted through the primary conduit via the primary distal end. The secondary tube defines a flow resistance of the primary and secondary tubes. The shunt body has a reservoir therein and is integrated with the primary tube near the primary distal end such that the primary and secondary conduits are fluidly coupled with the reservoir.

Abstract: A peristaltic pump system includes a peristaltic pump having a roller assembly and a roller assembly housing. The roller assembly is disposed within the housing. The peristaltic pump defines a tubing maximum diameter and is configured for use with conventional tubing having a conventional tubing wall thickness less than half of the tubing maximum diameter. The system includes peristaltic pump tubing including mainline tubing and outer sleeve tubing. The outer sleeve tubing is co-axially disposed about the mainline tubing. The mainline tubing and the outer sleeve tubing extend into, through, and out of the peristaltic pump and are engaged with the roller assembly. The mainline tubing has a mainline wall thickness. The outer sleeve tubing has a sleeve wall thickness. The mainline wall thickness and the sleeve wall thickness together are approximately the same as the conventional tubing wall thickness. A method of using the pump system is provided.

Abstract: A water sorption device includes a catalytic combustor configured to, in a desorption state, combust a hydrocarbon fuel mixture to generate heat; a thermoelectric generator configured to, in the desorption state, generate electricity from a first portion of the heat from the catalytic combustor; and an adsorber configured to in an adsorption state, adsorb water from ambient air from an environment and in the desorption state, desorb the adsorbed water as vapor using a second portion of the heat from the catalytic combustor.

Abstract: A water sorption device includes a catalytic combustor configured to, in a desorption state, combust a hydrocarbon fuel mixture to generate heat; a thermoelectric generator configured to, in the desorption state, generate electricity from a first portion of the heat from the catalytic combustor; and an adsorber configured to in an adsorption state, adsorb water from ambient air from an environment and in the desorption state, desorb the adsorbed water as vapor using a second portion of the heat from the catalytic combustor.

Abstract: A peristaltic pump system includes a peristaltic pump having a roller assembly and a roller assembly housing. The roller assembly is disposed within the housing. The peristaltic pump defines a tubing maximum diameter and is configured for use with conventional tubing having a conventional tubing wall thickness less than half of the tubing maximum diameter. The system includes peristaltic pump tubing including mainline tubing and outer sleeve tubing. The outer sleeve tubing is co-axially disposed about the mainline tubing. The mainline tubing and the outer sleeve tubing extend into, through, and out of the peristaltic pump and are engaged with the roller assembly. The mainline tubing has a mainline wall thickness. The outer sleeve tubing has a sleeve wall thickness. The mainline wall thickness and the sleeve wall thickness together are approximately the same as the conventional tubing wall thickness. A method of using the pump system is provided.

Abstract: An air inflatable and thus collapsible when air is removed, safety helmet preferably comprised of multiple inflatable lobes with a head conforming and surrounding inflatable ring and separate or integrated skull cap, for wear by the user, for placement on top of the lobes and/or for location within the chamber(s) formed of the lobes, or worn by the wearer directly upon the head, made of flexible, force absorbing and dissipating material. The lobes and ring are provided with quick release air inflation and deflation valves. The safety helmet can simply alternatively comprise air inflatable lobes with a minimally elastic outer covering to encase and minimize the movement or air within the chambers during a collision.

Abstract: An air inflatable and thus collapsible when air is removed, safety helmet preferably comprised of multiple inflatable lobes with a head conforming and surrounding inflatable ring and separate or integrated skull cap, for wear by the user, for placement on top of the lobes and/or for location within the chamber(s) formed of the lobes, or worn by the wearer directly upon the head, made of flexible, force absorbing and dissipating material. The lobes and ring are provided with quick release air inflation and deflation valves. The safety helmet can simply alternatively comprise air inflatable lobes with a minimally elastic outer covering to encase and minimize the movement or air within the chambers during a collision.

Abstract: Described are transdermal and transmucosal pharmaceutical compositions exhibiting reduced skin or mucosa irritation potential comprising a phytoestrogen and an antioxidant, useful for reducing the skin or mucosa irritation associated with the use of transdermal or transmucosal drug delivery compositions. Methods of making and using the compositions also are described.

Abstract: The invention provides a system for characterizing a patient undergoing hemodialysis, featuring: 1) a body-worn biometric sensor, worn on a single location of the patient, and featuring: i) sensing elements for measuring electrocardiogram (ECG), thoracic bio-impedance (TBI), photoplethysmogram (PPG), and phonocardiogram (PCG) waveforms; ii) a processor for collectively analyzing the ECG, TBI, PPG, and PCG waveforms to determine a set of physiological parameters; and iii) a first wireless transceiver configured to transmit the set of physiological parameters; 2) a gateway system comprising a second wireless transceiver configured to receive the set of physiological parameters; and 3) a data-analytics system configured to analyze the set of physiological parameters to determine the patient's status.

Abstract: Described are methods for oral administration of therapeutic proteins and peptides, more specifically to the oral administration of therapeutic proteins and peptides with gastric acid modulators, and compositions of comprising a gastric acid modulator and a protein or peptide.

Abstract: Described are transdermal pharmaceutical compositions exhibiting reduced skin irritation potential comprising a steroid and an antioxidant, useful for reducing the skin irritation associated with the use of transdermal drug delivery compositions. Methods of making and using the compositions also are described.

Abstract: A peristaltic pump system includes elastomeric pump tubing and a roller pump. The pump tubing has a pumping segment and an inlet segment. The inlet segment has an inlet segment outer diameter. The pumping segment has a pumping segment outer diameter less than the inlet segment outer diameter. The roller pump has a roller assembly and a roller assembly housing. The roller assembly is disposed within the roller assembly housing and engaged with the pumping segment within the roller assembly housing. The roller assembly housing has an inlet gap formed through the roller assembly housing. The inlet gap defines an inlet gap inner diameter smaller than the pumping segment outer diameter. The inlet gap is adapted to frictionally receive the inlet segment for aligning the pump tubing with a roller assembly and mitigate longitudinal movement of the pump tubing into the roller assembly housing.

Abstract: A system is described for breast imaging that includes spatially registering sequential mammographic images of the same breast. The system includes a first compression member configured to contact a first side of a breast, a second compression member configured to contact a second side of a breast that is substantially opposite the first side. The system further includes a first image sensor, coupled to the first compression member and configured to detect a position of a first fiducial marker located at the first side of the breast, and a second image sensor, coupled to the second compression member and configured to detect a position of a second fiducial marker located at the second side of the breast.

Abstract: A device and method for mitigating swelling and discomfort in a mesotherapy treatment area is disclosed. A compression band is wrapped around the treated area multiple times a day for a period of about 1 hour for each session after undergoing mesotherapy treatment.

Abstract: The present invention provides waterproof, breathable non-textile seamed articles which exhibit high levels of durability and allow wearers a high level of flexibility and article strength. This invention is of particular interest for use in dexterous hand coverings and conformable foot coverings.

Abstract: The present invention provides waterproof, breathable non-textile seamed articles which exhibit high levels of durability and allow wearers a high level of flexibility and article strength. This invention is of particular interest for use in dexterous hand coverings and conformable foot coverings.

Abstract: A peristaltic pump system includes elastomeric pump tubing and a roller pump. The pump tubing has a pumping segment and an inlet segment. The inlet segment has an inlet segment outer diameter. The pumping segment has a pumping segment outer diameter less than the inlet segment outer diameter. The roller pump has a roller assembly and a roller assembly housing. The roller assembly is disposed within the roller assembly housing and engaged with the pumping segment within the roller assembly housing. The roller assembly housing has an inlet gap formed through the roller assembly housing. The inlet gap defines an inlet gap inner diameter smaller than the pumping segment outer diameter. The inlet gap is adapted to frictionally receive the inlet segment for aligning the pump tubing with a roller assembly and mitigate longitudinal movement of the pump tubing into the roller assembly housing.

Abstract: A system is described for breast imaging that includes spatially registering sequential mammographic images of the same breast. The system includes a first compression member configured to contact a first side of a breast, a second compression member configured to contact a second side of a breast that is substantially opposite the first side. The system further includes a first image sensor, coupled to the first compression member and configured to detect a position of a first fiducial marker located at the first side of the breast, and a second image sensor, coupled to the second compression member and configured to detect a position of a second fiducial marker located at the second side of the breast.

Abstract: An infiltration cannula and method of using the infiltration cannula during a tumescent infiltration procedure are disclosed herein. The infiltration cannula may have an outwardly flaring hub which may be wedged into an adit of a patient to minimize leakage of fluid being infiltrated into the patient. Also, the infiltration cannula may be utilized to hydrate a dehydrated patient by a medically untrained person. The infiltration cannula may also be used to deliver an antibiotic/vasoconstrictive drug solution to minimize surgical site infections.