Patents by Inventor Jeffrey A. Kowalak

Jeffrey A. Kowalak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multi-dimension liquid chromatography separation system
    Patent number: 6802967
    Abstract: Liquid chromatography based on the difference of two or more kinds of separation modes, (e.g., chemical or physical properties of analytes) may improve separations when samples contain complex mixtures. In this invention, the analytes separated on the 1st analysis system (consisting of the 1st column and the 1st mobile phase) will be trapped onto individual trapping columns. Then the trapped analytes will be loaded onto the 2nd analysis system consisting of the 2nd column and the 2nd mobile phase. This invention has the trapping and loading mechanism consisting of a combination of switching valves necessary to produce the serial separations. Also this invention has the capability to affect online desalting when it is needed depending on a detector or the nature of the analyte mixture.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: October 12, 2004
    Assignees: Shimadzu Corporation, The United States of America as represented by the Department of Health and Human Services
    Inventors: Junichi Masuda, Edward J. Unsworth, Jeffrey A. Kowalak, Sanford P. Markey
  • Multi-dimensional liquid chromatography separation system
    Publication number: 20030168392
    Abstract: Liquid chromatography based on the difference of two or more kinds of separation modes, (e.g., chemical or physical properties of analytes) may improve separations when samples contain complex mixtures. In this invention, the analytes separated on the 1st analysis system (consisting of the 1st column and the 1st mobile phase) will be trapped onto individual trapping columns. Then the trapped analytes will be loaded onto the 2nd analysis system consisting of the 2nd column and the 2nd mobile phase. This invention has the trapping and loading mechanism consisting of a combination of switching valves necessary to produce the serial separations. Also this invention has the capability to affect online desalting when it is needed depending on a detector or the nature of the analyte mixture.
    Type: Application
    Filed: March 6, 2002
    Publication date: September 11, 2003
    Applicant: Shimadzu Corporation and The Government of the United States of America,
    Inventors: Junichi Masuda, Edward J. Unsworth, Jeffrey A. Kowalak, Sanford P. Markey
  • Methods and compositions for bisubstrate inhibitors of acetyltransferases
    Publication number: 20020002144
    Abstract: The present invention provides a method of producing a bisubstrate inhibitor in a cell, comprising introducing into the cell an alkylating derivative of an acetyl acceptor substrate for an acetyltransferase present in the cell. Further provided is a method of inhibiting the activity of an acetyltransferase in a cell, comprising introducing into the cell an alkylating derivative of an acetyl acceptor substrate for an acetyltransferase present in the cell under conditions whereby a bisubstrate inhibitor will be produced, thereby inhibiting the activity of the acetyltransferase in the cell.
    Type: Application
    Filed: July 20, 2001
    Publication date: January 3, 2002
    Applicant: The Government of the United States of America, Department of Health & Human Services
    Inventors: David C. Klein, M. A.A. Namboodiri, Joan L. Weller, Jeffrey A. Kowalak, Anthony K. Ho