Abstract: Compounds inhibit memapsin 2 ?-secretase activity and selectively inhibit memapsin 2 ?-secretase activity relative to memapsin 1 ?-secretase activity. The compounds are employed in methods to inhibit memapsin 2 ?-secretase activity, in the treatment of Alzheimer's disease, in the inhibition of hydrolysis of a ?-secretase site of a ?-amyloid precursor protein and to decrease ?-amyloid protein in in vitro samples and in mammals. Proteins of memapsin 2 associated with compounds of the invention are crystallized.

Abstract: Compounds inhibit memapsin 2 &bgr;-secretase activity and selectively inhibit memapsin 2 &bgr;-secretase activity relative to memapsin 1 &bgr;-secretase activity. The compounds are employed in methods to inhibit memapsin 2 &bgr;-secretase activity, in the treatment of Alzheimer's disease, in the inhibition of hydrolysis of a &bgr;-secretase site of a &bgr;amyloid precursor protein and to decrease &bgr;-amyloid protein in in vitro samples and in mammals. Proteins of memapsin 2 associated with compounds of the invention are crystallized.

Abstract: A mechanism for securing a door to a door frame includes a plurality of generally C-shaped clamps rotatably secured about the door's periphery, each of the clamps including a rear radial clamp leg engageable with the rear of the door frame, a forward radial clamp leg overlying the front surface of the door, and a connecting base extending between the radial legs, with inner cam surfaces on each radial leg and an outer cam surface on the forward radial leg. A plurality of wedges are slidably secured to the door front surface for radial movement between extended and retracted positions wherein the wedge respectively engages or does not engage the inner cam surface on an associated forward clamp leg to effect latching or unlatching of each clamp about the door and frame.