Patents by Inventor Jeffrey A. M. Coull

Jeffrey A. M. Coull has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of neuroglia-derived BDNF in the treatment and prevention of pain
    Patent number: 8187823
    Abstract: Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of neuroglia-derived BDNF expression or activity. Also described herein are commercial packages and uses based on such modulation. Related methods for identifying or characterizing compounds for the treatment of pain and the reduction of nociception are also described.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: May 29, 2012
    Assignees: Université Laval, The Hospital for Sick Children
    Inventors: Jeffrey A. M. Coull, Yves De Koninck, Michael Salter, Simon Beggs
  • Method for identifying compounds for treatment of pain
    Patent number: 8173376
    Abstract: Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of CNS intracellular chloride levels. The methods and products may also relate to modulation of the activity and/or expression of a chloride transporter, such as the KCC2 potassium-chloride cotransporter. Also described herein are commercial packages and uses based on such modulation. Related methods for identifying or characterizing a compound for the treatment of pain, the reduction of nociception and the diagnosis and prognostication of pain are also described.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: May 8, 2012
    Assignee: Universite Laval
    Inventors: Yves De Koninck, Paul De Koninck, Jeffrey A. M. Coull
  • METHOD FOR IDENTIFYING COMPOUNDS FOR TREATMENT OF PAIN
    Publication number: 20100330586
    Abstract: Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of CNS intracellular chloride levels. The methods and products may also relate to modulation of the activity and/or expression of a chloride transporter, such as the KCC2 potassium-chloride cotransporter. Also described herein are commercial packages and uses based on such modulation. Related methods for identifying or characterizing a compound for the treatment of pain, the reduction of nociception and the diagnosis and prognostication of pain are also described.
    Type: Application
    Filed: March 12, 2010
    Publication date: December 30, 2010
    Applicant: UNIVERSITE LAVAL
    Inventors: Yves DE KONINCK, Paul DE KONINCK, Jeffrey A.M. COULL
  • Method for identifying compounds for treatment of pain
    Patent number: 7718382
    Abstract: The present invention provides methods of preventing and treating pain, by modulating, e.g. inhibiting, the activity, function and/or expression of a PLC? in a subject. The invention further relates to methods of identifying agents capable of modulating the activity and/or expression of a PLC?, or capable of modulating binding of a ligand or binding partner to a PLC?, and their use thereof for the prevention and/or treatment of pain. In a further aspect, the invention provides methods for the diagnosis and prognostication of pain by determining whether there is modulation of activity and/or expression of a PLC? relative to a corresponding control.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: May 18, 2010
    Assignee: Universite Laval
    Inventors: Jeffrey A. M. Coull, Yves De Koninck
  • Method for identifying compounds for treatment of pain
    Patent number: 7709207
    Abstract: Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of CNS intracellular chloride levels. The methods and products may also relate to modulation of the activity and/or expression of a chloride transporter, such as the KCC2 potassium-chloride cotransporter. Also described herein are commercial packages and uses based on such modulation. Related methods for identifying or characterizing a compound for the treatment of pain, the reduction of nociception and the diagnosis and prognostication of pain are also described.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: May 4, 2010
    Assignee: Universite Laval
    Inventors: Yves De Koninck, Paul De Koninck, Jeffrey A. M. Coull
  • Modulation of Neuroglia-Derived BDNF in the Treatment and Prevention of Pain
    Publication number: 20090227654
    Abstract: Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods an products are based on the modulation of neuroglia-derived BDNF expression or activity. Also described herein are commercial packages and uses based on such modulation. Related methods for identifying or characterizing compounds for the treatment of pain and the reduction of nociception are also described.
    Type: Application
    Filed: September 30, 2005
    Publication date: September 10, 2009
    Applicants: UNIVERSITE LAVAL, THE HOSPITAL FOR SICK CHILDREN
    Inventors: Jeffrey A.M. Coull, Yves De Koninck, Michael Salter, Simon Beggs
  • Phospholipase C Gamma Modulation and Uses Thereof for Management of Pain and Nociception
    Publication number: 20080260718
    Abstract: The present invention provides methods of preventing and treating pain, by modulating, e.g. inhibiting, the activity, function and/or expression of a PLC? in a subject. The invention further relates to methods of identifying agents capable of modulating the activity and/or expression of a PLC?, or capable of modulating binding of a ligand or binding partner to a PLC?, and their use thereof for the prevention and/or treatment of pain. In a further aspect, the invention provides methods for the diagnosis and prognostication of pain by determining whether there is modulation of activity and/or expression of a PLC? relative to a corresponding control.
    Type: Application
    Filed: May 13, 2005
    Publication date: October 23, 2008
    Inventors: Jeffrey A.M. Coull, Yves De Koninck