Patents by Inventor Jeffrey A. Marks

Jeffrey A. Marks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250027881
    Abstract: An instrument for processing and/or measuring a biological process comprises a sample processing system and an excitation source exhibiting a spectral function of output power or intensity verses wavelength of output power or intensity. The spectral function has a minima wavelength corresponding to a local minima value of the output power or intensity; a first maxima wavelength corresponding to a first local maxima of output power or intensity, the output power or intensity at the first local maxima being greater than the output power or intensity at any wavelength less than the minima wavelength; a second maxima wavelength corresponding to a second local maxima of output power or intensity, the output power or intensity at the second local maxima being greater than the output at any wavelength greater than the minima wavelength; the minima wavelength is between the first maxima wavelength and the second maxima wavelength.
    Type: Application
    Filed: July 8, 2024
    Publication date: January 23, 2025
    Inventors: Mingsong Chen, Jeffrey A. Marks, Jacob K. Freudenthal, Mauro Aguanno, Woon Liang Terence Soh, Kuan Moon Boo
  • Patent number: 12031916
    Abstract: An instrument for processing and/or measuring a biological process comprises a sample processing system and an excitation source exhibiting a spectral function of output power or intensity verses wavelength of output power or intensity. The spectral function has a minima wavelength corresponding to a local minima value of the output power or intensity; a first maxima wavelength corresponding to a first local maxima of output power or intensity, the output power or intensity at the first local maxima being greater than the output power or intensity at any wavelength less than the minima wavelength; a second maxima wavelength corresponding to a second local maxima of output power or intensity, the output power or intensity at the second local maxima being greater than the output at any wavelength greater than the minima wavelength; the minima wavelength is between the first maxima wavelength and the second maxima wavelength.
    Type: Grant
    Filed: October 7, 2022
    Date of Patent: July 9, 2024
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Mingsong Chen, Mauro Aguanno, Kuan Moon Boo, Woon Liang Terence Soh, Jacob K. Freudenthal, Jeffrey A. Marks
  • Patent number: 11467092
    Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: October 11, 2022
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Mingsong Chen, Mauro Aguanno, Kuan Moon Boo, Woon Liang Terence Soh, Jacob K. Freudenthal, Jeffrey A. Marks
  • Patent number: 11417037
    Abstract: A method for generating a data visualization is provided. The method includes displaying a representation of a portion of detected data from a substrate to a user. The method further includes generating a data quality value for the portion of detected data and displaying, along with the representation of the portion of detected data, an indication of data quality value for the portion of detected data. The method further includes selecting, by the user, a quality value threshold, and displaying an adjusted indication of data quality value for the portion of detected data meeting the quality value threshold.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: August 16, 2022
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Harrison Leong, Nivedita Sumi Majumdar, Jeffrey A. Marks, Theodore E. Straub, Ryan J. Talbot, Kevin S. Bodner, David Hoard
  • Publication number: 20210313010
    Abstract: A computer-implemented method for designing a digital PCR (dPCR) experiment is provided. The method includes receiving, from a user, a selection of optimization type. The optimization type may be maximizing the dynamic range, minimizing the number of substrates including reaction sites needed for the experiment, determining a dilution factor, or determining the lower limit of detection, for example. The method further includes receiving, from the user, a precision measure for an experiment, and a minimum concentration of a target in a reaction site for the experiment. The method also includes determining a set of dPCR experiment design factors for the experiment based on the optimization type. The set of dPCR experiment design factors is then displayed to the user.
    Type: Application
    Filed: March 19, 2021
    Publication date: October 7, 2021
    Inventors: Nivedita Sumi Majumdar, Thomas Wessel, David C. Woo, Marcin Sikora, Gordon A. Janaway, Shweta Raizada, Joanna Lankester, Jeffrey A. Marks, Daniel Wessel
  • Patent number: 10984888
    Abstract: A computer-implemented method for designing a digital PCR (dPCR) experiment is provided. The method includes receiving, from a user, a selection of optimization type. The optimization type may be maximizing the dynamic range, minimizing the number of substrates including reaction sites needed for the experiment, determining a dilution factor, or determining the lower limit of detection, for example. The method further includes receiving, from the user, a precision measure for an experiment, and a minimum concentration of a target in a reaction site for the experiment. The method also includes determining a set of dPCR experiment design factors for the experiment based on the optimization type. The set of dPCR experiment design factors is then displayed to the user.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: April 20, 2021
    Assignee: Life Technologies Corporation
    Inventors: Nivedita Sumi Majumdar, Thomas Wessel, David C. Woo, Marcin Sikora, Gordon A. Janaway, Shweta Raizada, Joanna Lankester, Jeffrey A. Marks, Daniel Wessel
  • Patent number: 10726589
    Abstract: A method for generating a data visualization is provided. The method includes displaying a representation of a portion of detected data from a substrate to a user. The method further includes generating a data quality value for the portion of detected data and displaying, along with the representation of the portion of detected data, an indication of data quality value for the portion of detected data. The method further includes selecting, by the user, a quality value threshold, and displaying an adjusted indication of data quality value for the portion of detected data meeting the quality value threshold.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: July 28, 2020
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Harrison Leong, Nivedita Sumi Majumdar, Jeffrey A. Marks, Theodore E. Straub, Ryan J. Talbot, Kevin S. Bodner, David Hoard
  • Patent number: 10591416
    Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: March 17, 2020
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Mingsong Chen, Mauro Aguanno, Kuan Moon Boo, Woon Liang Terence Soh, Jacob K. Freudenthal, Jeffrey A. Marks
  • Patent number: 9495741
    Abstract: A method for calibrating a biological instrument is provided. The method comprises the steps of acquiring an image of at least one biological sample array, determining a first region of interest within the image, wherein the first region of interest comprises a first plurality of locations on the at least one biological array; and identifying within the first region of interest, a plurality of image elements associated with each of the first plurality of locations on the at least one biological array.
    Type: Grant
    Filed: September 30, 2012
    Date of Patent: November 15, 2016
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Jacob K. Freudenthal, Jeffrey A. Marks, Francis T. Cheng, Thomas Wessel
  • Publication number: 20150278437
    Abstract: A computer-implemented method for designing a digital PCR (dPCR) experiment is provided. The method includes receiving, from a user, a selection of optimization type. The optimization type may be maximizing the dynamic range, minimizing the number of substrates including reaction sites needed for the experiment, determining a dilution factor, or determining the lower limit of detection, for example. The method further includes receiving, from the user, a precision measure for an experiment, and a minimum concentration of a target in a reaction site for the experiment. The method also includes determining a set of dPCR experiment design factors for the experiment based on the optimization type. The set of dPCR experiment design factors is then displayed to the user.
    Type: Application
    Filed: September 13, 2013
    Publication date: October 1, 2015
    Inventors: Nivedita Sumi Majumdar, Thomas Wessel, David C. Woo, Marcin Sikora, Gordon A. Janaway, Shweta Raizada, Joanna Lankester, Jeffrey A. Marks, Daniel Wessel
  • Publication number: 20150269756
    Abstract: A method for generating a data visualization is provided. The method includes displaying a representation of a portion of detected data from a substrate to a user. The method further includes generating a data quality value for the portion of detected data and displaying, along with the representation of the portion of detected data, an indication of data quality value for the portion of detected data. The method further includes selecting, by the user, a quality value threshold, and displaying an adjusted indication of data quality value for the portion of detected data meeting the quality value threshold.
    Type: Application
    Filed: November 7, 2013
    Publication date: September 24, 2015
    Inventors: Harrison Leong, Nivedita Sumi Majumdar, Jeffrey A. Marks, Theodore E. Straub, Ryan J. Talbot, Kevin S. Bodner, David Hoard
  • Publication number: 20140294268
    Abstract: A method for calibrating a biological instrument is provided. The method comprises the steps of acquiring an image of at least one biological sample array, determining a first region of interest within the image, wherein the first region of interest comprises a first plurality of locations on the at least one biological array; and identifying within the first region of interest, a plurality of image elements associated with each of the first plurality of locations on the at least one biological array.
    Type: Application
    Filed: September 30, 2012
    Publication date: October 2, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Jacob K. Freudenthal, Jeffrey A. Marks, Francis T. Cheng, Thomas Wessel