Abstract: The present invention provides methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators, and compositions having low impurity levels.

Abstract: A server system is communicatively connected to a plurality of computing devices and one or more databases. The server system receives one or more queries from a computing device. The one or more queries specify a data source. The server system determines a level of security applicable to a user of the computing device. The server system translates the one or more queries into one or more logical queries according to semantics of the data source, and transmits the logical queries to a query pipeline of the server system. The server system executes the one or more queries against a first database of the one or more databases to retrieve query results from the data source. The server system applies the determined level of security to the query results to obtain one or more data sets, and returns the one or more data sets to the computing device.

Abstract: The present invention provides crystalline forms of (E)-6-(4-Phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione, and methods of making and using the same.

Abstract: Training a lexicon of a natural language processing system may include receiving a data set containing a corpus of absolute paths driven by a vehicle annotated with natural language descriptions of said absolute paths and determining parameters of the lexicon based on the data set. The degree to which a path taken by the vehicle satisfies the annotated description may be specified by a scoring function. The lexicon may be determined by finding the lexicon parameters that optimize the degree to which the paths taken by the vehicle satisfy the annotated descriptions. Objects in the environment of the same class are disambiguated by specifying their position relative to other objects using prepositions.

Abstract: Aspects of the present disclosure generally relate to systems and methods for flight control of aircrafts driven by electric propulsion systems and in other types of vehicles. In some embodiments, a flight control system of an aircraft is disclosed, configured to receive one or more signals to control movement of the aircraft, determine at least one flight condition of the aircraft, wherein the at least one flight condition includes at least a phase of flight, calculate at least one or more loads associated with the aircraft based on the determined at least one flight condition; determine an optimized flight configuration to alleviate loads on one or more components of the aircraft based on the received one or more signals and the calculated loads, generate one or more effector commands based on the optimized flight configuration; and actuate one or more aircraft effectors based on the one or more effector commands.

Abstract: In one embodiment, an operating system of a computing system determines, by an application instance manager of the operating system, that a first instance corresponding to a first application is to be activated according to an instance database managed by the operating system, where the first application includes several application components, including the first instance and a presenter. The application instance manager invokes the first instance and the presenter, the presenter being managed by the first instance. The operating system determines that the presenter is configured to present data obtained by a data provider, the data provider being one of several application components of a second application. The data provider accesses data from a data store and populates a dataset defined by the second application. The presenter of the first application generates a user interface to present the data from the dataset defined by the second application.

Abstract: Vacuum-integrated photoresist-less methods and apparatuses for forming metal hardmasks can provide sub-30 nm patterning resolution. A metal-containing (e.g., metal salt or organometallic compound) film that is sensitive to a patterning agent is deposited on a semiconductor substrate. The metal-containing film is then patterned directly (i.e., without the use of a photoresist) by exposure to the patterning agent in a vacuum ambient to form the metal mask. For example, the metal-containing film is photosensitive and the patterning is conducted using sub-30 nm wavelength optical lithography, such as EUV lithography.

Abstract: A sleeve for retention of a surgical port is disclosed. The sleeve comprises a first sleeve portion, a second sleeve portion, a plurality of flanges, and a reversible locking mechanism. The second sleeve portion is disposed around the first sleeve portion and is reversibly slidable distally from a first position to a second position along the first sleeve portion. The plurality of flanges is disposed in a radial sequence around the first sleeve portion. The flanges are radially collapsed along the first sleeve portion when the second sleeve portion is in the first position and are radially expanded when the second sleeve portion is in the second position. The first sleeve portion is configured for placement of a surgical port therethrough and to be fixedly secured to the surgical port therealong. Additional sleeves are also disclosed.

Abstract: An instrument for processing and/or measuring a biological process comprises a sample processing system and an excitation source exhibiting a spectral function of output power or intensity verses wavelength of output power or intensity. The spectral function has a minima wavelength corresponding to a local minima value of the output power or intensity; a first maxima wavelength corresponding to a first local maxima of output power or intensity, the output power or intensity at the first local maxima being greater than the output power or intensity at any wavelength less than the minima wavelength; a second maxima wavelength corresponding to a second local maxima of output power or intensity, the output power or intensity at the second local maxima being greater than the output at any wavelength greater than the minima wavelength; the minima wavelength is between the first maxima wavelength and the second maxima wavelength.

Abstract: A system and method which allows the basic checkpoint-reverse-mode AD strategy (of recursively decomposing the computation to reduce storage requirements of reverse-mode AD) to be applied to arbitrary programs: not just programs consisting of loops, but programs with arbitrarily complex control flow. The method comprises (a) transforming the program into a formalism that allows convenient manipulation by formal tools, and (b) introducing a set of operators to allow computations to be decomposed by running them for a given period of time then pausing them, while treating the paused program as a value subject to manipulation.

Abstract: Certain embodiments provide a method of providing added peripheral IDS activity to a subject with Hunter syndrome, comprising administering to the subject a therapeutically effective dose of a pharmaceutical composition comprising a protein comprising an IDS amino acid sequence and a TfR binding domain. The added peripheral IDS activity can be measured by comparing levels of keratan sulfate (KS) in the subject after administration of the pharmaceutical composition relative to a baseline level. Certain embodiments also provide methods of providing a clinical benefit to a subject with Hunter syndrome and improving treatment in a patient having non-neuronopathic Hunter syndrome, as well as methods and treatment regimens for resolving infusion related reactions (IRRs).

Abstract: The present invention provides methods of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators, methods of preparing intermediates of pyrimidine cyclohexyl glucocorticoid receptor modulators, and pyridinium compounds.

Abstract: A computing device generates and displays a data visualization in a data visualization user interface. The data visualization includes a plurality of visual data marks representing data from a data source. The computing device detects a first user input to select a visual data mark of the plurality of visual data marks. In response to detecting the first user input, the computing device identifies a first aggregated data value, for the visual data mark, corresponding to a first data field in the data source. The computing device retrieves a first disaggregated set of data rows corresponding to the first aggregated data value, from a first table, in the data source, containing the first data field. The computing device displays, in the data visualization user interface, a plurality of data rows from the first disaggregated set of data rows.

Abstract: The present invention provides methods of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators, methods of preparing intermediates of pyrimidine cyclohexyl glucocorticoid receptor modulators, and thioether compounds.

Abstract: A client device receives one or more inputs for generating a data visualization according to a data source. The device determines one or more requirements for generating the data visualization. The device sends a request to a network gateway that is communicatively connected to the client device and a plurality of data servers, and receives, from the network gateway, capabilities of each data server. The device determines, according to the received capabilities, that a first data server of the plurality of data servers includes a first set of capabilities that satisfies the requirements for generating the data visualization. The device sends, via the network gateway, one or more queries to the first data server and receives, from the first data server, one or more data sets from the data source. The device generates the data visualization according to the retrieved data sets and displays the data visualization.

Abstract: A data signal receiver circuit, including: a comparator configured to generate a first data signal based on a comparison of an input data signal and a reference voltage, wherein the first data signal includes a first logic low pulse and a first logic high pulse; and a duty cycle control circuit configured to generate: a second data signal based on the first data signal, wherein the second data signal includes a second logic low pulse responsive to the first logic low pulse, wherein the second logic low pulse has a width greater than a unit interval (UI); and a third data signal based on the first data signal, wherein the third data signal includes a second logic high pulse responsive to the first logic high pulse, wherein the second logic high pulse has a width greater than the UL.

Abstract: A system for directing the motion of a vehicle, comprising receiving commands in natural language using a processor, the commands specifying a relative path to be taken by the vehicle with respect to other objects in the environment; and determining an absolute path for the vehicle to follow based on the relative path using the processor, the absolute path comprising a series of coordinates in the environment; and directing the vehicle along the absolute path. Also provided is a system for training a lexicon of a natural language processing system, comprising receiving a data set containing a corpus of absolute paths driven by a vehicle annotated with natural language descriptions of the absolute paths using a processor, and determining parameters of the lexicon based on the data set.

Abstract: Development of resists are useful, for example, to form a patterning mask in the context of high-resolution patterning. Development can be accomplished using a halide-containing chemistry such as a hydrogen halide. A metal-containing resist film may be deposited on a semiconductor substrate using a dry or wet deposition technique. The resist film may be an EUV-sensitive organo-metal oxide or organo-metal-containing thin film resist. After exposure, the photopatterned metal-containing resist is developed using wet or dry development.

Abstract: Aspects of the present disclosure generally relate to systems and methods for flight control of aircrafts driven by electric propulsion systems and in other types of vehicles. In some embodiments, a flight control system of an aircraft is disclosed, configured to receive one or more signals to control movement of the aircraft, determine at least one flight condition of the aircraft, wherein the at least one flight condition includes at least a phase of flight, calculate at least one or more loads associated with the aircraft based on the determined at least one flight condition; determine an optimized flight configuration to alleviate loads on one or more components of the aircraft based on the received one or more signals and the calculated loads, generate one or more effector commands based on the optimized flight configuration; and actuate one or more aircraft effectors based on the one or more effector commands.

Abstract: The present disclosure relates generally to flight control of electric aircraft and other powered aerial vehicles. In one embodiment, an electrical system for an aircraft is disclosed, comprising: at least one processor configured to: receive pilot input indicating a commanded aircraft state, determine an aircraft thrust for achieving the commanded aircraft state, retrieve at least one propeller parameter associated with propeller speeds, wherein the propeller parameter is determined to reduce a structural vibratory response in the aircraft. The at least one processor is further configured to determine a respective command for each propeller of the aircraft to achieve the determined aircraft thrust based on the at least one propeller parameter and control each propeller of the aircraft based on the corresponding respective command.