Abstract: Embodiments of the present disclosure are directed to an array substrate which can be used in nucleic acid sequencing, which includes a plurality of fiducial domains (FDs). The disclosure also includes array substrate manufacturing methods and methods for making FDs on such substrates.

Abstract: A method of monitoring a patient's foot forms a thermogram of the sole of at least one foot of the patient, and determines whether the thermogram presents at least one of a plurality of prescribed patterns. The method also compares the thermogram against a prior thermogram of the same foot, and produces output information indicating the emergence of an ulcer on a given portion on the at least one foot as a function of 1) whether the thermogram is determined to present the at least one pattern, and 2) the comparison with the prior thermogram, which shows non-ulcerated tissue at the given location.

Abstract: An instrument for processing and/or measuring a biological process comprises a sample processing system and an excitation source exhibiting a spectral function of output power or intensity verses wavelength of output power or intensity. The spectral function has a minima wavelength corresponding to a local minima value of the output power or intensity; a first maxima wavelength corresponding to a first local maxima of output power or intensity, the output power or intensity at the first local maxima being greater than the output power or intensity at any wavelength less than the minima wavelength; a second maxima wavelength corresponding to a second local maxima of output power or intensity, the output power or intensity at the second local maxima being greater than the output at any wavelength greater than the minima wavelength; the minima wavelength is between the first maxima wavelength and the second maxima wavelength.

Abstract: A delay interpolator includes pull-up devices coupled between a supply rail and a node, pull-down devices coupled between the node and a ground, and a first control circuit coupled to the pull-up devices, wherein the first control circuit is configured to receive a first signal, a second signal, and a first delay code, input the first signal to a programmable number of the pull-up devices based on the first delay code, and input the second signal to remaining ones of the pull-up devices. The delay interpolator also includes a second control circuit coupled to the pull-down devices, wherein the second control circuit is configured to receive the first signal, the second signal, and a second delay code, input the first signal to a programmable number of the pull-down devices based on the second delay code, and input the second signal to remaining ones of the pull-down devices.

Abstract: A method for etching features in a stack below a patterned mask in an etch chamber is provided. The stack is cooled with a coolant with a coolant temperature below ?20° C. An etch gas is flowed into the etch chamber. A plasma is generated from the etch gas. Features are selectively etched into the stack with respect to the patterned mask.

Abstract: A system and method which allows the basic checkpoint-reverse-mode AD strategy (of recursively decomposing the computation to reduce storage requirements of reverse-mode AD) to be applied to arbitrary programs: not just programs consisting of loops, but programs with arbitrarily complex control flow. The method comprises (a) transforming the program into a formalism that allows convenient manipulation by formal tools, and (b) introducing a set of operators to allow computations to be decomposed by running them for a given period of time then pausing them, while treating the paused program as a value subject to manipulation.

Abstract: A computer generates and displays a data visualization in a data visualization user interface according to placement of data fields, from a data source. The data visualization includes visual data marks representing data from the data source. The computer detects a user input to select a visual data mark. In response to detecting the user input, the computer obtains a data model encoding the data source as a tree of logical tables. The computer identifies one or more aggregated data values for the visual data mark, each of the aggregated data values corresponding to a respective data field in the data model. For each of the aggregated data values, the computer retrieves a respective disaggregated set of data rows from a respective logical table containing the respective data field. The computer displays a summary grid, with a respective tab corresponding to each of the retrieved disaggregated sets of data rows.

Abstract: A device may receive security data identifying assets of an entity, security issues associated with the assets, and objectives associated with the assets and may utilize a data model to generate, based on the security data, asset related data identifying mapped sets of security data. The device may process a first portion of the asset related data, with a first model, to calculate an asset risk likelihood score for an asset of the assets and may process a second portion of the asset related data, with a second model, to calculate an asset criticality score for the asset. The device may process a third portion of the asset related data, with a third model, to calculate an asset control effectiveness score for the asset and may combine the scores to generate a security risk score for the asset. The device may provide the security risk score for display.

Abstract: A method of ionising a sample is disclosed comprising nebulising a sample which includes monoclonal antibody (“mAb”) molecules. A stream of monoclonal antibody droplets or charged droplets is directed so as to impact upon a target or electrode so as to form intact parent monoclonal antibody ions, intact minus light chain parent monoclonal antibody ions or light chain (“LC”) fragment monoclonal antibody ions.

Abstract: A method comprises displaying, on a graphical user interface (GUI), a first data visualization comprising a positional representation of a plurality of reaction sites from at least a portion of a substrate, wherein the positional representation of the first data visualization simultaneously indicates relative data quality of the plurality of reaction sites; and altering the first data visualization displayed on the GUI to a second data visualization, the second data visualization comprising the positional representation of the plurality of reaction sites from the at least the portion of the substrate, wherein the positional representation of the second data visualization simultaneously indicates relative data quality of the plurality of reaction sites from at least the portion of the substrate based on a comparison of the data quality values of the plurality of reaction sites an adjusted quality value threshold.

Abstract: The present invention provides crystalline forms of (E)-6-(4-Phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione, and methods of making and using the same.

Abstract: Provided are a computer program product, system, and method for geo-spatial analysis to determine boundaries of traffic regions and classifications of the boundaries for controlling drop-off/pick-up traffic. A determination is made of drop-off/pick-up points for vehicles in traffic regions in which vehicles dropped-off and/or picked-up passengers. Geo-spatial cluster analysis is applied to the determined drop-off/pick-up points to determine boundaries of the traffic regions having drop-off/pick-up points forming clusters of similar drop-off/pick-up point densities. A determination is made of a respective classification for each respective one of the boundaries. Each respective classification indicates a relative density of drop-off/pick-up points in its respective boundary relative to densities of drop-off/pick-up points in other one of the boundaries. Classification related information based on the determined classifications is communicated to use to control drop-off/pick-up traffic in the traffic regions.

Abstract: A hand wash station may include at least three wash areas including sinks so users can wash their hands. Each wash area may be supported to a non-coplanar side of the hand wash station. At least one divider wall may separate the wash areas from each other to protect the users from the spread of germs. The hand wash station may be mobile in that it is designed to be easily movable from one location to another.

Abstract: A delay interpolator includes pull-up devices coupled between a supply rail and a node, pull-down devices coupled between the node and a ground, and a first control circuit coupled to the pull-up devices, wherein the first control circuit is configured to receive a first signal, a second signal, and a first delay code, input the first signal to a programmable number of the pull-up devices based on the first delay code, and input the second signal to remaining ones of the pull-up devices. The delay interpolator also includes a second control circuit coupled to the pull-down devices, wherein the second control circuit is configured to receive the first signal, the second signal, and a second delay code, input the first signal to a programmable number of the pull-down devices based on the second delay code, and input the second signal to remaining ones of the pull-down devices.

Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.

Abstract: A method generates a data source. A user selects a first data set from a displayed object model of a database. The object model includes data sets linked visually by many-to-one relationships to form a tree. The user selects a data field in the first data set and specifies a filter condition. The system identifies a second data set in the tree, and joins the first and second data sets. When the second data set is related to the first data set via one or more many-to-one relationships, rows of the second data set are joined to rows of the first data set that satisfy the first filter condition. When the second data does not satisfy the condition, the second data set is joined to rows of the first data set that satisfy the first filter condition, and all rows of the second data set are included in the generation.

Abstract: A method for generating a data visualization is provided. The method includes displaying a representation of a portion of detected data from a substrate to a user. The method further includes generating a data quality value for the portion of detected data and displaying, along with the representation of the portion of detected data, an indication of data quality value for the portion of detected data. The method further includes selecting, by the user, a quality value threshold, and displaying an adjusted indication of data quality value for the portion of detected data meeting the quality value threshold.

Abstract: A system and method which allows the basic checkpoint-reverse-mode AD strategy (of recursively decomposing the computation to reduce storage requirements of reverse-mode AD) to be applied to arbitrary programs: not just programs consisting of loops, but programs with arbitrarily complex control flow. The method comprises (a) transforming the program into a formalism that allows convenient manipulation by formal tools, and (b) introducing a set of operators to allow computations to be decomposed by running them for a given period of time then pausing them, while treating the paused program as a value subject to manipulation.

Abstract: Development of resists are useful, for example, to form a patterning mask in the context of high-resolution patterning. Development can be accomplished using a halide-containing chemistry such as a hydrogen halide. A metal-containing resist film may be deposited on a semiconductor substrate using a dry or wet deposition technique. The resist film may be an EUV-sensitive organo-metal oxide or organo-metal-containing thin film resist. After exposure, the photopatterned metal-containing resist is developed using wet or dry development.

Abstract: The present invention provides methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators, and compositions having low impurity levels.