Abstract: Disclosed herein includes a drug delivery system comprising at least one peptide and a targeting ligand for bone fracture and/or for bone healing. Some embodiments include a peptide delivery system comprising at least an acidic, basic, hydrophilic, hydrophobic or neutral peptide linked to an acidic peptide or nonpeptidic polyanion for use in targeting the aforementioned attached peptide to a bone fracture surface. In some embodiments, a conjugated peptide expresses an anabolic function that acts through PTH receptor 1, and various formats of targeting ligands guide the drug to raw hydroxyapatite.

Abstract: In one example in accordance with the present disclosure, a fluid ejection die is described. The fluid ejection die includes a fluid feed slot to deliver fluid from a reservoir to an array of nozzles. Each nozzle of the array includes an ejection chamber, an opening, a fluid actuator disposed within the ejection chamber, and a fluid channel between the fluid feed slot and the ejection chamber. The fluid ejection die also includes a fluid cleaning structure to allow live cells in the fluid to pass to the nozzle while capturing other components.

Abstract: A method of sequencing multiple nucleic acid sequences, including: estimating a concentration of cells in a solution; and depositing a volume of the solution into a well on a well plate using an ejection device, the amount of solution selected to contain no more than a single cell.

Abstract: A system for partitioning a liquid sample, the system including: an ejection device, the ejection device comprising an array of nozzles, wherein adjacent nozzles are separated by a constant distance in a first axis; and a microfluidics device including: a plurality of intake ports to receive a deposited droplet, wherein pairs of intake ports are separated by the same constant distance in the same first axis such that adjacent nozzles can simultaneously eject droplets to different intake ports.

Abstract: In one example in accordance with the present disclosure, a fluidic ejection controller is described. The fluidic ejection controller includes a firing board to pass electrical control signals for ejecting fluid from a fluidic ejection device. An ejection board of the fluidic ejection controller is electrically coupled to, and selectively removable from, the firing board to pass the electrical control signals to the fluidic ejection device. Electrical pins are disposed on the ejection board in a pattern that matches a pattern of electrical pads on the fluidic ejection device. The electrical pins interface with corresponding electrical pads to pass the electrical control signals from the ejection board to the fluidic ejection device.

Abstract: An apparatus includes a print head coupled to a substrate to dispense fluid from the substrate in response to a command. A reservoir coupled to the substrate transports the fluid to the print head. A preloaded storage container mounted on the reservoir stores the fluid and provides the fluid to the reservoir in response to pressure applied to the container.

Abstract: In example implementations, a method is provided. The method may be executed by a processor of a fluid dispensing apparatus. The method includes storing a correction factor for an unqualified fluid. A request to dispense the unqualified fluid is received. A dispense parameter is adjusted in accordance with the correction factor. Then, the unqualified fluid is dispensed in accordance with the dispense parameter that is adjusted.

Abstract: Examples described herein also provide a substrate conveyance system. The substrate conveyance system may include a conveyor surface to convey a number of substrates, and a number of apertures defined in the conveyor surface between the substrates as positioned on the conveyor surface. The location of the apertures is based on a location at which at least one reagent module dispenses a reagent.

Abstract: A reagent dispensing system may, in an example, include a processing device, a memory device coupled to the processing device, and a plurality of swappable reagent dispensing cartridges wherein a first set of the swappable reagent dispensing cartridges are maintained within a storage device off-line from a second set of swappable reagent dispensing cartridges maintained in-line.

Abstract: An example printhead assembly includes a housing, nozzles and a collapsible container within the housing to supply ink to the nozzles. The collapsible container includes a top wall, a bottom wall, first and second side walls that form an interior and a spring assembly within the interior. The first flexible wall includes a first amount of excess material. The second flexible wall includes a second amount of excess material less than the first amount of excess material such that motion of the first flexible wall of the collapsible container is constrained against movement to a lesser extent as compared to the second flexible wall. The first flexible wall faces the sensor. A sensor assembly is coupled to the housing and includes a sensor to provide a sensor signal indicating the amount of ink within the collapsible container.

Abstract: A reagent deposition area of a reagent dispensing system may include a dispersion bar located above a conveyor system, and a reagent module coupled to the dispersion bar. The reagent module may include at least one reagent dispensing device to dispense a number of reagents on a substrate carried on the conveyor system, and a module frame electrically and mechanically coupling the reagent dispensing device to the reagent dispensing system. The dispersion bar moves the reagent module in two coordinate directions planar with the surface of the substrate.

Abstract: One example of a printhead assembly includes a housing including sidewalls, nozzles to eject ink drops, a collapsible container, and a sensor assembly. The collapsible container is within the housing to supply ink to the nozzles. The collapsible container includes flexible sidewalls and a spring assembly between the flexible sidewalls. The sensor assembly is coupled to the housing and includes a sensor to provide a sensor signal indicating the amount of ink within the collapsible container.

Abstract: An inkjet material dispenser system includes a printhead member. According to one exemplary embodiment, the printhead member includes at least one drop ejector including an insulating stack layer and a top orifice surface defining an orifice, wherein a ratio of a diameter of the orifice to a height of the insulating stack layer (O/L ratio) is at least 1.0.

Abstract: A microplate lid is disclosed. An electronics board includes a plurality of board throughholes corresponding to well locations of a microplate. A cover plate includes a plurality of plate throughholes corresponding to respective board throughholes to define a plurality of plate-board throughhole pairs. The cover plate is located atop the electronics board. A plurality of directing lumens is at least partially defined by the cover plate. Each directing lumen corresponds to a respective plate throughhole. A plurality of user-perceptible array indicators is provided to the electronics board. Each array indicator is associated with a different plate-board throughhole pair than every other array indicator.

Abstract: An apparatus includes a pipette dispenser to control dispensing of a volume to a dispensing location. A tip is operatively coupled to the pipette dispenser. The tip includes an electromechanical print head to dispense the volume from the pipette dispenser to the dispensing location based on a command from the pipette dispenser that indicates an amount of the volume to be dispensed from the print head.

Abstract: According to an example, a microfluidic apparatus may include a channel, a foyer, in which the foyer is in fluid communication with the channel and in which the channel has a smaller width than the foyer, a sensor to sense a property of a fluid passing through the channel, a nozzle in fluid communication with the foyer, and an actuator positioned in line with the nozzle. The microfluidic apparatus may also include a controller to determine whether the sensed property of the fluid meets a predetermined condition and to perform a predefined action in response to the sensed property of the fluid meeting the predetermined condition.

Abstract: According to an example, a microfluidic apparatus may include a fluid slot, a foyer in fluid communication with the fluid slot via a channel having a relatively smaller width than the foyer, a sensor to detect a presence of a particle of interest in a fluid passing through the channel, a nozzle in fluid communication with the foyer, and an actuator positioned in line with the nozzle. The microfluidic apparatus may also include a controller to receive information from the sensor, determine, from the received information, whether a particle of interest has passed through the channel, and control the actuator to expel fluid in the foyer through the nozzle based upon the determination.

Abstract: A digital dispense apparatus comprising a plurality of fluid dispense devices, at least one reservoir connected to the plurality of fluid dispense devices to deliver fluid to the plurality of fluid dispense devices, at least one contact pad array, and a single monolithic carrier structure.

Abstract: A digital dispense apparatus includes at least one fluid dispense device, at least one reservoir fluidically connected to the at least one fluid dispense device, a monolithic carrier structure carrying the at least one fluid dispense device and reservoir, the monolithic carrier forming fluid routing between the reservoir and the fluid dispense device.

Abstract: In an example implementation, a method of multiple dispense technology 3D printing includes receiving digital model data representing an object. The method includes formatting the data into an Mvec (material vector) specification that includes an Mvec to specify a material component of a voxel. The Mvec can have an associated dispense technology (DT) index to identify one of multiple available dispense technologies for dispensing the material component.