Patents by Inventor Jeffrey A. Robl

Jeffrey A. Robl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HMG-CoA reductase inhibitors and method
    Publication number: 20020013334
    Abstract: Compounds of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids such as lowering LDL cholesterol and/or increasing HDl cholesterol, and treating hyperlipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis 1
    Type: Application
    Filed: June 6, 2001
    Publication date: January 31, 2002
    Inventors: Jeffrey A. Robl, Bang-Chi Chen, Chong-Qing Sun
  • Processes and intermediates for preparing benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
    Patent number: 6235922
    Abstract: Compounds having the following formula I, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: wherein: Y1 and Y2 are each independently hydrogen, alkyl, aryl, halogen, or alkoxy; X is O or S(O)t; A is t is zero, one or two; m and n are independently zero or one; and wherein R, R5, R5a, R5b, R6, R7, R11, q and r are defined herein.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: May 22, 2001
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Jeffrey A. Robl, Chong-Qing Sun
  • Azepinone compounds useful in the inhibition of ACE and NEP
    Patent number: 6143886
    Abstract: Compounds having the following formulae I and II, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## and wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.5a, R.sup.5b, R.sup.6, R.sup.7, R.sup.11, q and r are defined herein.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: November 7, 2000
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Jeffrey A. Robl
  • Process for preparing azepinone compounds useful in the inhibition of ACE and NEP
    Patent number: 5994537
    Abstract: Compounds having the following formulae I and II, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## and wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.5a, R.sup.5b, R.sup.6, R.sup.7, R.sup.11, q and r are defined herein.
    Type: Grant
    Filed: February 14, 1998
    Date of Patent: November 30, 1999
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Jeffrey A. Robl
  • Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
    Patent number: 5877313
    Abstract: Compounds having the following formula I, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## wherein: Y.sup.1 and Y.sup.2 are each independently hydrogen, alkyl, aryl, halogen, or alkoxy;X is O or S(O).sub.t ;A is ##STR2## t is zero, one or two; m and n are independently zero or one;and wherein R, R.sup.5, R.sup.5a, R.sup.5b, R.sup.6, R.sup.7, R.sup.11, q and r are defined herein.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: March 2, 1999
    Assignee: Bristol-Myers Squibb
    Inventors: Jeffrey A. Robl, Chong-Qing Sun
  • Mercaptoalkanoylamino and acylmercaptoalkanoylamino benzoxazepines and benzothiazepines
    Patent number: 5859239
    Abstract: Compounds of the formula ##STR1## wherein X.sub.1 is ##STR2## are disclosed. These compounds possess inhibitory activity against angiotensin converting enzyme and neutral endopeptidase and thus useful as cardiovascular agents.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: January 12, 1999
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Jeffrey A. Robl
  • Azepinones useful as intermediates in the preparation of inhibitors of angiotensin converting enzyme and neutralendopeptidase
    Patent number: 5856477
    Abstract: The azepine intermediates of the formula ##STR1## wherein R.sub.6 and R.sub.7 are other than hydrogen are disclosed. These intermediates can be reacted with acylmercaptocarboxylic acids of the formula ##STR2## to give the pharmaceutically active products.
    Type: Grant
    Filed: July 30, 1996
    Date of Patent: January 5, 1999
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Jeffrey A. Robl
  • Processes for preparing azepiones useful as intermediates in the preparation of inhibitors of angiotensin converting enzyme and neutral endopeptidase
    Patent number: 5856476
    Abstract: Processes are disclosed for preparing the azepine intermediates of the formula ##STR1## These intermediates can be reacted with acylmercaptocarboxylic acids of the formula ##STR2## to give the pharmaceutically active products.
    Type: Grant
    Filed: October 8, 1997
    Date of Patent: January 5, 1999
    Assignee: E. R. Squibbs & Sons, Inc.
    Inventor: Jeffrey A. Robl
  • Inhibitors of microsomal triglyceride transfer protein and method
    Patent number: 5827875
    Abstract: Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.6, Q, W and X are as defined herein.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: October 27, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Dickson, Jr., Jeffrey A. Robl, Scott A. Biller
  • Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
    Patent number: 5760246
    Abstract: Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2;R.sup.x is H, alkyl, aryl or halogen;A is(1) a bond;(2) --O--; or(3) ##STR2## B is: ##STR3## and wherein L.sup.2, L.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.3', R.sup.3a, R.sup.3b, R.sup.4, R.sup.4', R.sup.5, X, ##STR4## are as defined herein.
    Type: Grant
    Filed: December 17, 1996
    Date of Patent: June 2, 1998
    Inventors: Scott A. Biller, John K. Dickson, R. Michael Lawrence, David R. Magnin, Michael A. Poss, Jeffrey A. Robl, William A. Slusarchyk, Richard B. Sulsky, Joseph A. Tino
  • Process for preparing amino acid esters useful as intermediates for compounds containing a fused bicyclic ring
    Patent number: 5756832
    Abstract: Amino acid esters of the formula ##STR1## wherein m is zero or one and R.sub.3 is an acid protecting group are prepared. These amino acid esters are useful as intermediates in the preparation of fused bicyclic ring compounds.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: May 26, 1998
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Jeffrey A. Robl
  • Azepinone compounds useful in the inhibition of ACE and NEP
    Patent number: 5750687
    Abstract: Compounds having the following formulae I and II, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## wherein: A is ##STR2## and wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.5a, R.sup.5b, R.sup.6, R.sup.7, R.sup.11, q and r are defined herein.
    Type: Grant
    Filed: August 20, 1996
    Date of Patent: May 12, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventor: Jeffrey A. Robl
  • Acylmercaptoalkanoylamino and mercaptoalkanoylamino benzazepines
    Patent number: 5723457
    Abstract: Compounds of the formula ##STR1## wherein X.sub.1 is ##STR2## are disclosed. These compounds possess inhibitory activity against angiotensin converting enzyme and neutral endopeptidase and thus are useful as cardiovascular agents.
    Type: Grant
    Filed: July 8, 1996
    Date of Patent: March 3, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Jeffrey A. Robl
  • Dual action inhibitors containing a pyridazinodiazepine or pyrazolodiazepine lactam ring
    Patent number: 5723602
    Abstract: Compounds of the formula ##STR1## wherein X.sub.1 is ##STR2## are disclosed. These compounds possess inhibitory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and are thus useful as cardiovascular agents.
    Type: Grant
    Filed: April 17, 1995
    Date of Patent: March 3, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Jeffrey A. Robl
  • Inhibitors of microsomal triglyceride transfer protein and method
    Patent number: 5712279
    Abstract: Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein Z, X.sup.1, X.sup.2, x and R.sup.5 are as defined herein.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: January 27, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Scott A. Biller, John K. Dickson, R. Michael Lawrence, David R. Magnin, Michael A. Poss, Jeffrey A. Robl, Richard B. Sulsky, Joseph A. Tino
  • Compounds containing a fused bicycle ring
    Patent number: 5672599
    Abstract: Compounds of the formula ##STR1## wherein X is O or S--(O).sub.t ; n is one; m is zero or one; Y is CH.sub.2, O, or S--(O).sub.t provided that Y is O or S--(O).sub.t only when m is one; and A is ##STR2## are dual inhibitors of NEP and ACE. Compounds wherein A is ##STR3## are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.
    Type: Grant
    Filed: November 22, 1995
    Date of Patent: September 30, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Jeffrey A. Robl
  • Process for preparing amino acid esters useful as intermediates for compounds containing a fused bicyclic ring
    Patent number: 5670699
    Abstract: Amino acid esters of the formulas ##STR1## wherein m is zero or one and R.sub.3 is an acid protecting group are prepared. These amino acid esters are useful as intermediates in the preparation of fused bicyclic ring compounds.
    Type: Grant
    Filed: January 17, 1996
    Date of Patent: September 23, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Jeffrey A. Robl
  • Spiro lactam dual action inhibitors
    Patent number: 5654294
    Abstract: Compounds of the formula ##STR1## are disclosed as possessing inhibotory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being useful as cardiovascular agents. Processes for preparing these compounds are also disclosed.
    Type: Grant
    Filed: June 19, 1996
    Date of Patent: August 5, 1997
    Assignee: Bristol-Myers Squibb
    Inventor: Jeffrey A. Robl
  • Diazepine containing dual action inhibitors
    Patent number: 5646276
    Abstract: Compounds of the formula ##STR1## wherein X.sub.1 is ##STR2## are disclosed as possessing inhibotory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being useful as cardiovascular agents.
    Type: Grant
    Filed: June 19, 1996
    Date of Patent: July 8, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Jeffrey A. Robl
  • Fused multiple ring lactams
    Patent number: 5637698
    Abstract: Compounds of the formula ##STR1## are useful as intermediates in the preparation of compounds possessing ACE and NEP inhibition activity.
    Type: Grant
    Filed: February 26, 1996
    Date of Patent: June 10, 1997
    Assignee: Bristol-Myers Squibb Co.
    Inventor: Jeffrey A. Robl