Abstract: The present invention relates to compositions comprising TWIST signaling inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.

Abstract: A method of making an apparatus for continuously casting a lead alloy strip includes providing a drum having an aluminum outer circumferential casting surface. The outer circumferential casting surface of the drum is abraded with an angular abrading medium to wear away material from the aluminum outer circumferential casting surface of the drum and to create a coarse, irregular, and non-smooth abraded casting surface configured to reduce the rate of heat transfer and slow cooling of the lead alloy strip cast on the abraded casting surface.

Abstract: A method and apparatus for continuously casting lead alloy strip on a casting surface on substantially the upper half of a rotatable casting drum from a pool of molten lead alloy at a high speed comprising imparting a coarse texture to the casting surface, providing a tundish containing a pool of the molten lead alloy at a predetermined temperature adjacent a substantially vertical upwardly-moving portion of said casting drum, the tundish having a graphite lip insert having an open front defined by a lip insert floor and opposed sidewalls cooperating with and commencing at a substantially vertical portion of the casting surface to contain said molten lead alloy in the lip insert, controlling the height of the surface level and temperature of the molten lead alloy in the lip insert, moving the casting surface upwardly through the pool of molten lead alloy by rotating said drum for depositing the lead alloy thereon, cooling the casting surface of the drum to solidify a strip of the lead alloy on substantially t

Abstract: An apparatus for direct casting of strip from a pool of molten metal includes a tundish having a feed chamber, a return chamber and a diverting chamber. A lip insert is inserted into the tundish and has an open front for cooperation with a casting surface. The apparatus includes a control mechanism configured to control the surface level of the pool of molten metal in the diverting chamber and in the lip insert, and a movement mechanism configured to move the casting surface upwardly through the pool of molten metal for the casting of metal on the casting surface. The casting surface is an aluminum surface of a cylindrical drum and has a coarse irregular surface formed thereon by biasing with crushed, angular silicon carbide or aluminum silicate.

Abstract: A method of continuously casting a lead alloy strip includes continuously supplying molten lead alloy to a tundish having a lip insert and containing a pool of molten lead alloy. The molten lead alloy is continuously supplied to the pool from a bath maintained at a temperature in the range of 575° to 750° F. The surface level of the molten alloy in the lip insert is controlled to produce a strip of desired thickness. The temperature of the lead alloy in the lip insert is controlled in a range of about 640° to 750° F. An abraded casting surface is moved upwardly through the pool for depositing the lead alloy thereon. The abraded casting surface is cooled to a temperature in the range of about 100° to 210° F. to solidify a strip of lead alloy, and the lead alloy strip is stripped from the abraded casting surface.

Abstract: An apparatus for direct casting of strip from a pool of molten metal includes a tundish having a feed chamber, a return chamber and a diverting chamber. A lip insert is inserted into the tundish and has an open front for cooperation with a casting surface. The apparatus includes means for controlling the surface level of the pool of molten metal in the diverting chamber and in the lip insert, and means for moving the casting surface upwardly through the pool of molten metal for the casting of metal on the casting surface. The casting surface is an aluminum surface of a cylindrical drum and has a coarse irregular surface formed thereon by biasing with crushed, angular silicon carbide or aluminum silicate.

Abstract: A method and apparatus for continuously casting lead alloy strip on a casting surface on substantially the upper half of a rotatable casting drum from a pool of molten lead alloy at a high speed comprising imparting a coarse texture to the casting surface, providing a tundish containing a pool of the molten lead alloy at a predetermined temperature adjacent a substantially vertical upwardly-moving portion of said casting drum, the tundish having a graphite lip insert having an open front defined by a lip insert floor and opposed sidewalls cooperating with and commencing at a substantially vertical portion of the casting surface to contain said molten lead alloy in the lip insert, controlling the height of the surface level and temperature of the molten lead alloy in the lip insert, moving the casting surface upwardly through the pool of molten lead alloy by rotating said drum for depositing the lead alloy thereon, cooling the casting surface of the drum to solidify a strip of the lead alloy on substantially t