Patents by Inventor Jeffrey A. Toretsky

Jeffrey A. Toretsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD99 inhibitors and their uses
    Patent number: 11202792
    Abstract: Provided herein are methods of treating a bone or connective tissue cancer in a subject. The methods comprise administering to the subject an effective amount of a CD99 inhibitor, wherein the CD99 inhibitor is a compound having the formula wherein R, each of which may be the same or different, is hydrogen, or a protecting group; wherein Z is selected from the group consisting of F, Cl and Br; wherein X is H or F; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: December 21, 2021
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Aykut Üren, Haydar Celik, Jeffrey A. Toretsky
  • CD99 Inhibitors and Their Uses
    Publication number: 20190262370
    Abstract: Provided herein are methods of treating cancer in a subject. Also provided are methods of treating autoimmune disorders. The methods comprise administering to the subject an effective amount of a CD99 inhibitor.
    Type: Application
    Filed: October 12, 2017
    Publication date: August 29, 2019
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Aykut Üren, Haydar Celik, Jeffrey A. Toretsky
  • Targeting of EWS-FLI1 as anti-tumor therapy
    Patent number: 9758481
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: September 12, 2017
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Jeffrey A. Toretsky, Aykut Uren, Milton Lang Brown, Yali Kong
  • Methods and compositions for treating Ewings sarcoma family of tumors
    Patent number: 9714222
    Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: July 25, 2017
    Assignee: Georgetown University
    Inventors: Jeffrey A. Toretsky, Milton Lang Brown, Perrer N. Tosso, Aykut Uren, Yali Kong
  • METHODS AND COMPOSITIONS FOR TREATING CANCER
    Publication number: 20170157089
    Abstract: Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.
    Type: Application
    Filed: November 30, 2016
    Publication date: June 8, 2017
    Inventors: Jeffrey A. Toretsky, Aykut Uren
  • Methods and compositions for treating cancer
    Patent number: 9511050
    Abstract: Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: December 6, 2016
    Assignee: Georgetown University
    Inventors: Jeffrey A. Toretsky, Aykut Uren
  • METHODS AND COMPOSITIONS FOR TREATING CANCER
    Publication number: 20160263086
    Abstract: Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.
    Type: Application
    Filed: October 20, 2014
    Publication date: September 15, 2016
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Jeffrey A. Toretsky, Aykut Uren
  • METHODS AND COMPOSITIONS FOR TREATING EWINGS SARCOMA FAMILY OF TUMORS
    Publication number: 20160159741
    Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
    Type: Application
    Filed: February 10, 2016
    Publication date: June 9, 2016
    Inventors: Jeffrey A. Toretsky, Milton Lang Brown, Perrer N. Tosso, Aykut Uren, Yali Kong
  • Methods and compositions for treating Ewings sarcoma family of tumors
    Patent number: 9290449
    Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: March 22, 2016
    Assignee: Georgetown University
    Inventors: Jeffrey A. Toretsky, Milton Lang Brown, Perrer N. Tosso, Aykut Uren, Yali Kong
  • TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY
    Publication number: 20150329488
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Application
    Filed: April 24, 2015
    Publication date: November 19, 2015
    Inventors: Jeffrey A. Toretsky, Aykut Uren, Milton Lang Brown, Yali Kong
  • Targeting of EWS-FLI1 as anti-tumor therapy
    Patent number: 9045415
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: June 2, 2015
    Assignee: Georgetown University
    Inventors: Jeffrey A. Toretsky, Aykut Üren, Milton Lang Brown, Yali Kong
  • METHODS AND COMPOSITIONS FOR TREATING EWINGS SARCOMA FAMILY OF TUMORS
    Publication number: 20150051260
    Abstract: Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
    Type: Application
    Filed: April 11, 2013
    Publication date: February 19, 2015
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Jeffrey A. Toretsky, Milton Lang Brown, Perrer N. Tosso, Aykut Uren, Yali Kong
  • Targeting of EWS-FLI1 as anti-tumor therapy
    Patent number: 8232310
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: July 31, 2012
    Assignee: Georgetown University
    Inventors: Jeffrey A. Toretsky, Aykut Üren, Milton Lang Brown, Yali Kong
  • TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY
    Publication number: 20100167994
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Application
    Filed: March 9, 2010
    Publication date: July 1, 2010
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Jeffrey A. Toretsky, Aykut Üren, Milton Lang Brown, Yali Kong
  • TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY
    Publication number: 20100004179
    Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
    Type: Application
    Filed: June 29, 2009
    Publication date: January 7, 2010
    Inventors: Jeffrey A. Toretsky, Aykut Uren, Milton Lang Brown, Yali Kong
  • Novel F-18 labeled annexin V, synthesis thereof, and use thereof
    Publication number: 20070031333
    Abstract: A method for noninvasive measurement of apoptosis is described. The method includes the steps of labeling Annexin V with a positron emitter, injecting the labeled Annexin V into a target cell group, obtaining an image of the target cell group using a positron emission tomography scanner, and evaluating the image to determine an amount of cell death within the target cell group. The target cell group may be a lesion or a suspected tumor. The positron emitter may be F-18. The step of labeling Annexin V with F-18 may include the steps of selecting an F-18 labeled small molecule containing a protein conjugating group, synthesizing and purifying the selected molecule, producing a high specific activity prosthetic group as a result of the synthesizing and purifying step, and conjugating the prosthetic group to the Annexin V. The produced prosthetic group may be N-succinimidyl-4-[18F]fluorobenzoate (SFB).
    Type: Application
    Filed: December 22, 2003
    Publication date: February 8, 2007
    Inventors: Ronnie Mease, Jeffrey Toretsky, Irving Weinberg