Abstract: According to one embodiment, a method, computer system, and computer program product for managing access to data is provided. The embodiment may include identifying two or more users. The embodiment may also include identifying one or more data regulation requirements. The embodiment may further include determining a set of data rules from the one or more data regulation requirements. The embodiment may also include identifying a data set. The embodiment may further include determining, in response to a request for a subset of data from the data set, an access state to the subset of data for a user from the two or more users based on one or more data rules from the set of data rules. The embodiment may also include generating filtered data according to the determined access state.

Abstract: Systems and methods for automatic management of multiple accounts are provided. Example embodiments of the present disclosure provide a server configured to authenticate a user, detect the user is visiting an online website associated with a merchant, create a user account with the merchant for the user, where the user account including a user name and a password. The server can be further configured to retrieve personal identifiable information (PII) of the user from a financial account associated with the user, where the PII including information of a payment card of the user, provision the PII of the user to the merchant; and store the password.

Abstract: An object processing system is disclosed that includes a first support structure for supporting a plurality of containers that are positioned to receive a plurality of objects, a second support structure for receiving any of the plurality of containers when each of the plurality of containers is ready to be discharged from the first support structure, and an automated mobile transfer unit for selectively transferring a selected container from the first support structure to the second support structure, said automated mobile transfer unit including a mobile chassis unit for moving the at least one automated mobile transfer unit in a first direction among the first support structure and the second support structure, and a payload transfer system supported by the mobile chassis unit and adapted to transfer a selected container of the plurality of containers from the first support structure to the second support structure.

Abstract: An object processing system is disclosed that includes a distribution system for distributing a plurality of objects among a plurality of containers, an output conveyance system for receiving a plurality of completed containers, and a container discharge system for emptying any contents of a container of the plurality of completed containers into a destination location, the container discharge system including a discharge conveyor section in which the container is suspended and moved in a conveyor direction while permitting a bottom of the container to drop open to discharge any contents of the container into the destination location.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating a computer chip placement. One of the methods includes obtaining netlist data for a computer chip; and generating a computer chip placement, comprising placing a respective macro node at each time step in a sequence comprising a plurality of time steps, the placing comprising, for each time step: generating an input representation for the time step; processing the input representation using a node placement neural network having a plurality of network parameters, wherein the node placement neural network is configured to process the input representation in accordance with current values of the network parameters to generate a score distribution over a plurality of positions on the surface of the computer chip; and assigning the macro node to be placed at the time step to a position from the plurality of positions using the score distribution.

Abstract: Embodiments of the disclosed technologies include, responsive to a first use of a first application by a first user, configuring, in a first prompt, at least one instruction based on first application context data and first user context data. The first prompt is stored in a memory that is accessible to the first application and a second application. Via the second application, first output of a generative artificial intelligence (GAI) model is presented to the first user. Based on the first output of the GAI model, at least one second use of the first application by the first user, or at least one first use of a third application by the first user, is configured.

Abstract: The present invention provides crystalline forms of a pentaaza macrocyclic ring complex according to the following formula: Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of disease states.

Abstract: Embodiments herein are directed to an occlusion device that includes a body, a pair of lobes, and an adjustment assembly. One of the pair of lobes positioned at a distal portion of the body and the other one is positioned at a proximal portion. The body includes an adjustment assembly positioned between the distal and the proximal portions to change a distance between the pair of lobes. The adjustment assembly includes a receiving member and an elongated member. The elongated member is configured to move the body between an extended position and a retracted position, such that in the retracted position, the elongated member is received within an inner diameter of the receiving member. In the extended position, the elongated member is extended away from a first end of the receiving member such that the distance between the pair of lobes is increased.

Abstract: The following relates generally to accelerated magnetic resonance imaging (MRI) reconstruction. In some embodiments, a MRI machine learning algorithm is trained based on reference MRI data in non-Cartesian k-space. During the training, at each iteration of a plurality of iterations: (i) a non-Cartesian sampling trajectory ? may be optimized under the physical constraints, and/or (ii) an image reconstructor may be jointly iteratively optimized. Examples of the image reconstructor include a convolutional neural network (CNN) denoiser, a model-based deep learning (MoDL) image reconstructor, iterative image reconstructor, a regularizer, and an invertible neural network.

Abstract: The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.

Abstract: The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.

Abstract: The present invention generally relates to systems and methods for imaging or determining nucleic acids, for instance, within cells. In some embodiments, the transcriptome of a cell may be determined. Certain embodiments are directed to determining nucleic acids, such as mRNA, within cells at relatively high resolutions. In some embodiments, a plurality of nucleic acid probes may be applied to a sample, and their binding within the sample determined, e.g., using fluorescence, to determine locations of the nucleic acid probes within the sample. In some embodiments, codewords may be based on the binding of the plurality of nucleic acid probes, and in some cases, the codewords may define an error-correcting code to reduce or prevent misidentification of the nucleic acids. In certain cases, a relatively large number of different targets may be identified using a relatively small number of labels, e.g., by using various combinatorial approaches.

Abstract: Integrated substrate processing systems are disclosed that are able to achieve high-volume processing of substrates (e.g., greater than 120 substrates per hour) using environmentally sensitive processes and/or tools, such as photolithography processes and/or tools. In some embodiments, for example, the integrated substrate processing system may include an EFEM and a processing tool enclosure that are coupled together to form an integrated processing environment. The integrated substrate processing system may operate to maintain substantially uniform conditions (e.g., at a uniform temperature and relative humidity) throughout the integrated environment, and in some embodiments, may utilize an external air source, such as a remote air module (RAM), in order to do so. In some embodiments, high-volume processing of substrates may be further facilitated by employing specialized substrate handling robots and/or specially adapting the EFEM and/or processing tool enclosure.

Abstract: Provided herein are enzymes (e.g., cucurbitadienol synthases (CDS), UDP-glycosyltransferases (UGT), C11 hydroxylases, epoxide hydrolases (EPH), squalene epoxidases, and/or cytochrome P450 reductases), host cells expressing the enzymes, and methods of producing mogrol precursors, mogrol, and/or mogrosides using such host cells.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating a computer chip floorplan. One of the methods includes obtaining netlist data for a computer chip; and generating a computer chip floorplan, comprising placing a respective node at each time step in a sequence comprising a plurality of time steps, the placing comprising, for each time step: generating an input representation for the time step; processing the input representation using a node placement neural network having a plurality of network parameters, wherein the node placement neural network is configured to process the input representation in accordance with current values of the network parameters to generate a score distribution over a plurality of positions on the surface of the computer chip; and assigning the node to be placed at the time step to a position from the plurality of positions using the score distribution.

Abstract: The disclosure relates to compositions and methods for altering, e.g., enhancing, the expression of GCase proteins, whether in vitro and/or in vivo. Such compositions include delivery of an adeno-associated viral (AAV) particle. The compositions and methods of the present disclosure are useful in the treatment of subjects diagnosed with, or suspected of having Parkinson Disease or related condition resulting from a deficiency in the quantity and/or function of GBA gene product or associated with decreased expression or protein levels of GCase protein.

Abstract: A portable blower fan assembly that includes a housing that forms a pair of air tunnels. The pair of air tunnels are configured to provide a first airflow path across a surface in a downward direction. The portable blower fan assembly further includes a pair of fan assemblies. Each fan assembly is positioned within one of the air tunnels with a downward angle. The portable blower fan assembly further includes a power supply that is configured to provide electrical power to the first motor and the second motor.

Abstract: The present disclosure provides cell targeting constructs that specifically target cells of interest through the use of binding agents to cell surface nucleic acids, including without limitation extracellular DNA (exDNA). The cell targeting constructs can be engineered to deliver desired payload, including without limitation therapeutic agents and/or detectable labels, to the target cells.

Abstract: The present disclosure relates to formulations for coating a balloon of a balloon catheter, the formulations including one or more groups of microparticles that include a therapeutic agent. In some aspects, the microparticles are polymer microparticles with the therapeutic dispersed therein or crystalline microparticles of the therapeutic agent. In some aspects, the formulations further include an antioxidant and/or an excipient.

Abstract: Disclosed herein are system, method, and computer program product embodiments for generating a virtual replica of a physical network device and/or a physical network. An aspect operates by receiving, from a network management system (NMS), a request to generate a device digital twin (device-DT) instance corresponding to a physical network device, where the request includes at least a first plurality and a second plurality of device characteristics corresponding to the physical network device. A DT template is selected from a plurality of DT templates based on the first plurality of device characteristics. The DT template is customized based on the second plurality of device characteristics, and the device-DT instance of the physical network device is generated based on the customized DT template. Then a management channel is established between the device-DT instance and the NMS.