Abstract: An exchangeable lens platform (ELP) comprises a horseshoe-shaped ring structure, which has a memory strip incorporated therein, into which the haptic end components of the intraocular lens (IOL) can engage diametrically opposite portions of the ring structure. In this manner, the exchangeable lens platform (ELP) can not only be opened or expanded so as to be disposed within any sized capsular bag in a secure and stabilized manner, but diametrically opposite portions of the exchangeable lens platform (ELP) can effectively fold upon themselves such that the exchangeable lens platform (ELP) will effectively be partially folded in half such that the diametrically opposite folded portions of the exchangeable lens platform (ELP) can effectively engage diametrically opposed internal wall portions of the fornix of the capsular bag so as to permit the intraocular lens (IOL) to then be properly centered, oriented, stabilized, and secured within the eye.

Abstract: Embodiments provided herein relate to methods and compositions for treating mesothelioma and/or a small cell lung cancer that express midkine.

Abstract: A vitrector for performing a vitrectomy comprises a tubular shaft portion which is attached to a distal end of a vitrector hand piece. The shaft portion is provided with a sharply pointed needle tip portion for piercing the pars plana and sclera of the eye, and a pneumatically driven guillotine cutter is incorporated within the shaft portion of the vitrector at a location immediately adjacent to the sharply pointed needle tip portion. A source of pneumatic air is operatively connected to the proximal end of the vitrector hand piece and is pneumatically connected to the guillotine cutter so as to drive the same. In addition, an aspiration line is also operatively connected to the proximal end of the vitrector hand piece and is also fluidically connected to the region immediately adjacent to the pneumatically driven guillotine cutter so as to remove the floater particles, severed from the vitreous cavity by means of the pneumatically driven guillotine cutter, by means of aspiration.

Abstract: Embodiments provided herein relate to methods and compositions for treating mesothelioma and/or a small cell lung cancer that express midkine.

Abstract: A controlled release system including surfactant protein D (SPD) and a carrier suitable for controlled release that can be polylactic-co-glycolic acid (PLGA). The system can be in the form of a nanoparticle. A pharmaceutical composition including the system and a pharmaceutically acceptable carrier. Methods of treatment of a disease, disorder or condition associated with a decreased level of SPD in a subject, or for pulmonary delivery of SPD, include administering the pharmaceutical composition to a subject in need of such treatment.

Abstract: A tonic lens guide comprises a substantially linear bar member and a pair of crab claw members fixedly attached to opposite ends of the linear bar member. The toric lens guide is adapted to be mounted upon an intraocular lens (IOL) which has been implanted within the capsular bag of a human eye during cataract surgery such that the substantially linear bar member is adapted to be disposed atop the central optic component of the intraocular lens (IOL) while the crab claw members effectively grasp the optica/haptic junctions of the intraocular lens (IOL). After the intraocular lens (IOL) is implanted within the capsular bag, it is rotated within the capsular bag such that the substantially linear bar member of the toric lens guide will effectively define a diametrical vector across the intraocular lens (IOL) such that the cataract surgeon can precisely orient the intraocular lens (IOL) within the capsular bag such that the patient's astigmatism is optimally corrected.

Abstract: A vitrector for removing material from an eye includes a hand piece, a shaft coupled at a first end to a first end of the hand piece, the shaft having a sharp second end opposite the first end of the shaft, and a cutting device positioned within the shaft and configured for removing the material from the eye. The sharp second end of the shaft is configured for piercing a pars plana of the eye and a sclera of the eye. A method for removing material from an eye includes forming a single opening through a pars plana of the eye and a sclera of the eye using a sharp point of a shaft of a vitrector, cutting the material using a cutting device incorporated within the shaft, and removing the material from the eye using the vitrector.

Abstract: An anterior chamber maintainer (ACM), which is to be utilized in connection with maintaining physiological intraocular pressure during intraocular surgery is disclosed and is seen to comprise an axially elongated tubular member which is adapted to be fluidically connected at a first end to a supply of balanced salt solution (BSS) for introduction into the anterior chamber of an eye so as to maintain adequate intraocular pressure while performing any intraocular surgery. A second opposite end of the anterior chamber maintainer (ACM) is provided with a sharply pointed end for insertion through a paracentesis formed within the limbus region of the eye, and a deformable bulbous portion is interposed between the first and second ends such that as the second end passes through the paracentesis, the bulbous portion will diametrically deform and then diametrically expand, after also passing through the paracentesis, thereby trapping the anterior chamber maintainer (ACM) within the anterior chamber of the eye.

Abstract: Embodiments provided herein relate to methods and compositions for treating mesothelioma and/or a small cell lung cancer that express midkine.

Abstract: An exchangeable lens platform (ELP) comprises a horseshoe-shaped ring structure, which has a memory strip incorporated therein, into which the haptic end components of the intraocular lens (IOL) can engage diametrically opposite portions of the ring structure. In this manner, the exchangeable lens platform (ELP) can not only be opened or expanded so as to be disposed within any sized capsular bag in a secure and stabilized manner, but diametrically opposite portions of the exchangeable lens platform (ELP) can effectively fold upon themselves such that the exchangeable lens platform (ELP) will effectively be partially folded in half such that the diametrically opposite folded portions of the exchangeable lens platform (ELP) can effectively engage diametrically opposed internal wall portions of the fornix of the capsular bag so as to permit the intraocular lens (IOL) to then be properly centered, oriented, stabilized, and secured within the eye.

Abstract: Embodiments provided herein relate to methods and compositions for treating mesothelioma and/or a small cell lung cancer that express midkine.

Abstract: A tonic lens guide comprises a substantially linear bar member and a pair of crab claw members fixedly attached to opposite ends of the linear bar member. The toric lens guide is adapted to be mounted upon an intraocular lens (IOL) which has been implanted within the capsular bag of a human eye during cataract surgery such that the substantially linear bar member is adapted to be disposed atop the central optic component of the intraocular lens (IOL) while the crab claw members effectively grasp the optica/haptic junctions of the intraocular lens (IOL). After the intraocular lens (IOL) is implanted within the capsular bag, it is rotated within the capsular bag such that the substantially linear bar member of the toric lens guide will effectively define a diametrical vector across the intraocular lens (IOL) such that the cataract surgeon can precisely orient the intraocular lens (IOL) within the capsular bag such that the patient's astigmatism is optimally corrected.

Abstract: A vitrector for performing a vitrectomy comprises a tubular shaft portion which is attached to a distal end of a vitrector hand piece. The shaft portion is provided with a sharply pointed needle tip portion for piercing the pars plana and sclera of the eye, and a pneumatically driven guillotine cutter is incorporated within the shaft portion of the vitrector at a location immediately adjacent to the sharply pointed needle tip portion. A source of pneumatic air is operatively connected to the proximal end of the vitrector hand piece and is pneumatically connected to the guillotine cutter so as to drive the same. In addition, an aspiration line is also operatively connected to the proximal end of the vitrector hand piece and is also fluidically connected to the region immediately adjacent to the pneumatically driven guillotine cutter so as to remove the floater particles, severed from the vitreous cavity by means of the pneumatically driven guillotine cutter, by means of aspiration.

Abstract: Embodiments provided herein relate to methods and compositions for treating mesothelioma and/or a small cell lung cancer that express midkine.

Abstract: A controlled release system including surfactant protein D (SPD) and a carrier suitable for controlled release that can be polylactic-co-glycolic acid (PLGA). The system can be in the form of a nanoparticle. A pharmaceutical composition including the system and a pharmaceutically acceptable carrier. Methods of treatment of a disease, disorder or condition associated with a decreased level of SPD in a subject, or for pulmonary delivery of SPD, include administering the pharmaceutical composition to a subject in need of such treatment.

Abstract: A controlled release system includes surfactant protein D (SPD) and a carrier suitable for controlled release that can be polylactic-co-glycolic acid (PLGA). The system can be in the form of a nanoparticle. A pharmaceutical composition includes the system and a pharmaceutically acceptable carrier. Methods of treatment of a disease, disorder or condition associated with a decreased level of SPD in a subject, or for pulmonary delivery of SPD, include administering the pharmaceutical composition to a subject in need of such treatment.

Abstract: Embodiments provided herein relate to methods and compositions for treating mesothelioma and/or a small cell lung cancer that express midkine.

Abstract: Surfactant protein D (SP-D) is a member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. Described herein are methods and compositions for the treatment of disorders associated with lung injury, including methods and compositions for the treatment of bronchopulmonary disorder (BPD).

Abstract: Embodiments provided herein relate to methods and compositions for treating cancer. Some embodiments include treating lung cancers and renal cancers.

Abstract: Embodiments provided herein relate to methods and compositions for treating mesothelioma and/or a small cell lung cancer that express midkine.