Patents by Inventor Jeffrey Alan Ledbetter

Jeffrey Alan Ledbetter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-CD20 THERAPEUTIC COMPOSITIONS AND METHODS
    Publication number: 20100330089
    Abstract: The present invention provides materials and methods for treatment of diseases involving aberrant B-cell activity, using a CD20-specific binding molecule, in particular, antibodies or antigen binding fragment thereof. The compositions disclosed herein is useful for the treatment and diagnosis of B-cell disorders, such as B-cell malignancies and autoimmune diseases.
    Type: Application
    Filed: June 12, 2008
    Publication date: December 30, 2010
    Applicants: Wyeth, Trubion Pharmaceuticals Inc.
    Inventors: Nitin K. Damle, Lioudmila Tchistiakova, Kyriaki Dunussi-Joannopoulos, Sandy Alexander Simon, William Brady, Laura Sue Grosmaire, Jeffrey Alan Ledbetter
  • Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB
    Publication number: 20040058445
    Abstract: An improved method for ex-vivo generation of tumor-reactive T cells is provided, comprising culturing PBMC from a patient with cancer with autologous tumor cells and magnetic beads which activate T lymphocytes via CD3 in combination with CD28, CD40, or CD28 plus CD40. The invention also provides genes encoding anti-CD3 or anti-4-1BB scFv and methods to transfect cells of neoplastic or normal origin for expression of those genes at their surface. The genes and transfected tumor cells are useful compositions for induction of a tumor-destructive immune response.
    Type: Application
    Filed: March 26, 2002
    Publication date: March 25, 2004
    Inventors: Jeffrey Alan Ledbetter, Ingegerd Hellstrom, Martha Hayden-Ledbetter, Karl Erik Hellstrom