Abstract: Described herein are pharmaceutical formulations comprising 4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide, or a pharmaceutically acceptable salt thereof, wherein the pharmaceutical formulations are suitable for topical use, and methods of using such formulations in the treatment of subjects having cancer.

Abstract: A computerized airline flight reservation system simulator that allows air ravel carriers to simulate changes in flight schedules and predict the impact of those changes on a carrier's revenue. The simulator includes means for the input of host and other airline scheduled flight information which is used to build a global network of flight services offered on existing central reservation systems (CRS). The network is built according to CRS build and edit rules and simulates the screen display of reservation systems according to CRS display and sorting rules. The system simulates the screen presence on existing CRSs allowing the airline to predict the revenues derived from its present flight schedule and provides means to make proposed changes in its schedule and correspondingly see how such changes may impact revenues.