Abstract: Embodiments of the present disclosure include a coupling mechanism. The coupling mechanism may include a connection section including a first opening, an inner flange, and an outer flange, wherein the connection section is configured to connect to a first pipe, a sleeve portion including a second opening and configured to connect to a second pipe, and a channel extending through the coupling mechanism between the first opening and the second opening, wherein the first opening is angled relative to the second opening, wherein the inner flange includes a first end and a second end, wherein the first end of the inner flange includes a width larger than a width of the second end of the inner flange.

Abstract: Dry powder inhalers include electronic displays, readers and/or counters that can decrement dose amounts, inhibit misuse, read data on drug containment devices and/or communicate with remote devices. The dry powder containers can include at least a pair of cooperating generally tubular members, including an inner member and a generally tubular outer member sized and configured to slidably receive the inner member.

Abstract: Inhalers with fins that deagglomerate dry powder using inspiratory effort of a user of an inhaler. The inhaler fins, at least in steady state conditions, are configured to generate dry powder and airflow patterns having turbulence with flow vortices, some of which may have a vortex having an axis of rotation that extends in an inspiratory flow direction while others may have a vortex that is substantially orthogonal to the inspiratory flow direction in an inspiratory airflow path, as an amount of dry powder travels through the inhaler to thereby deagglomerate the dry powder without trapping undue amounts of the dry powder during inhalation.

Abstract: Embodiments of the present disclosure include a coupling mechanism. The coupling mechanism may include a connection section including a first opening, an inner flange, and an outer flange, wherein the connection section is configured to connect to a first pipe, a sleeve portion including a second opening and configured to connect to a second pipe, and a channel extending through the coupling mechanism between the first opening and the second opening, wherein the first opening is angled relative to the second opening, wherein the inner flange includes a first end and a second end, wherein the first end of the inner flange includes a width larger than a width of the second end of the inner flange.

Abstract: Dry powder inhalers include: (a) a first generally planar spiral travel path in an inhaler body, wherein the first spiral travel path has a plurality of adjacent curvilinear channels forming lanes with upstanding sidewalls, including an inner lane and an outer lane; and (b) a plurality of discrete sealed microcartridges with substantially rigid bodies disposed in the first travel path, each comprising a pre-metered (typically dose) amount of dry powder, the microcartridges being configured to slidably advance along the first travel path toward an inhalation chamber that merges into an inhalation output port. In operation, at least one microcartridge is held in the inhalation chamber to release the dry powder therein during inhalation.

Abstract: The disclosure describes methods and inhalers that deagglomerate dry powder using inspiratory effort of a user of an inhaler. Inhaler fin and mesh configurations are described that facilitate deagglomeration. At least in steady state conditions, a dry powder and airflow pattern can be generated having turbulence with flow vortices, some of which may have a vortex having an axis of rotation that extends in an inspiratory flow direction while others may have a vortex that is substantially orthogonal to the inspiratory flow direction in an inspiratory airflow path, as an amount of dry powder travels through the inhaler to thereby deagglomerate the dry powder without trapping undue amounts of the dry powder during inhalation.

Abstract: Dry powder inhalers include electronic displays, readers and/or counters that can decrement dose amounts, inhibit misuse, read data on drug containment devices and/or communicate with remote devices. The dry powder containers can include at least a pair of cooperating generally tubular members, including an inner member and a generally tubular outer member sized and configured to slidably receive the inner member.

Abstract: Pharmaceutical dry powder containers adapted for use in an inhaler and associated inhalers and kits thereof include at least a pair of cooperating generally tubular members, including an inner member and a generally tubular outer member sized and configured to slidably receive the inner member. In operation, at least one of the inner or outer members slide relative to the other to release a pharmaceutical dry powder.

Abstract: Dry powder inhalers include: (a) a first generally planar spiral travel path in an inhaler body, wherein the first spiral travel path has a plurality of adjacent curvilinear channels forming lanes with upstanding sidewalls, including an inner lane and an outer lane; and (b) a plurality of discrete sealed microcartridges with substantially rigid bodies disposed in the first travel path, each comprising a pre-metered (typically dose) amount of dry powder, the microcartridges being configured to slidably advance along the first travel path toward an inhalation chamber that merges into an inhalation output port. In operation, at least one microcartridge is held in the inhalation chamber to release the dry powder therein during inhalation.

Abstract: Dry powder inhalers include: (a) a first generally planar spiral travel path in an inhaler body, wherein the first spiral travel path has a plurality of adjacent curvilinear channels forming lanes with upstanding sidewalls, including an inner lane and an outer lane; and (b) a plurality of discrete sealed microcartridges with substantially rigid bodies disposed in the first travel path, each comprising a pre-metered (typically dose) amount of dry powder, the microcartridges being configured to slidably advance along the first travel path toward an inhalation chamber that merges into an inhalation output port. In operation, at least one microcartridge is held in the inhalation chamber to release the dry powder therein during inhalation.

Abstract: Dry powder inhalers with a multi-dose dry powder package for dispensing pharmaceutical grade formulations of inhalable dry powder, include: (a) a blister package comprising a plurality of spaced apart sealed blisters thereon, each blister having a projecting ceiling and a floor defining a blister channel therebetween, the blister channel comprising a dry powder therein; (b) a movable blade cartridge holding a blade at a forward portion thereof; and (c) an extendable mouthpiece attached to the movable blade cartridge. In operation, a user pulls the mouthpiece outward and then pushes the mouthpiece inward to cause the blister package to advance to position a blister in a selected dispensing position in the inhaler and to cause the blade cartridge to move the blade across a blister ceiling held in the dispensing position in the inhaler to thereby open the blister held in the dispensing position.

Abstract: Dry powder blister packages include sealed blisters with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.

Abstract: Pharmaceutical dry powder containers adapted for use in an inhaler and associated inhalers and kits thereof include at least a pair of cooperating generally tubular members, including an inner member and a generally tubular outer member sized and configured to slidably receive the inner member. In operation, at least one of the inner or outer members slide relative to the other to release a pharmaceutical dry powder.

Abstract: The disclosure describes methods and inhalers that deagglomerate dry powder using inspiratory effort of a user of an inhaler. Inhaler fin and mesh configurations are described that facilitate deagglomeration. At least in steady state conditions, a dry powder and airflow pattern can be generated having turbulence with flow vortices, some of which may have a vortex having an axis of rotation that extends in an inspiratory flow direction while others may have a vortex that is substantially orthogonal to the inspiratory flow direction in an inspiratory airflow path, as an amount of dry powder travels through the inhaler to thereby deagglomerate the dry powder without trapping undue amounts of the dry powder during inhalation.

Abstract: Dry powder blister packages include sealed blisters with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.