Patents by Inventor Jeffrey Allen Hughes

Jeffrey Allen Hughes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Materials and methods for intracellular delivery of biologically active molecules
    Patent number: 6627618
    Abstract: The subject invention finds utility in the area of gene therapy of diseases. More specifically, the invention concerns the making of a novel non-viral vector which can bind to desired DNA to form a combination useful to transfect diseased mitochondria of human or animal cells. The non-viral vector comprises a dequalinium salt subjected to standard liposome production procedures to obtain the vector named DQAsomes.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: September 30, 2003
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Volkmar Weissig, Jeffrey Allen Hughes, Jürgen Lasch, Thomas Cardon Rowe
  • Materials and methods for intracellular delivery of biologically active molecules
    Publication number: 20010001067
    Abstract: The subject invention finds utility in the area of gene therapy of diseases. More specifically, the invention concerns the making of a novel non-viral vector which can bind to desired DNA to form a combination useful to transfect diseased mitochondria of human or animal cells. The non-viral vector comprises a dequalinium salt subjected to standard liposome production procedures to obtain the vector named DQAsomes.
    Type: Application
    Filed: January 5, 2001
    Publication date: May 10, 2001
    Inventors: Volkmar Weissig, Jeffrey Allen Hughes, Jurgen Lasch, Thomas Cardon Rowe
  • Materials and methods for intracellular delivery of biologically active molecules
    Patent number: 6171863
    Abstract: The subject invention finds utility in the area of gene therapy of diseases. More specifically, the invention concerns the making of a novel non-viral vector which can bind to desired DNA to form a combination useful to transfect diseased mitochondria of human or animal cells. The non-viral vector comprises a dequalinium salt subjected to standard liposome production procedures to obtain the vector names DQAsomes.
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: January 9, 2001
    Assignee: University of Florida
    Inventors: Volkmar Weissig, Jeffrey Allen Hughes, J{umlaut over (u)}rgen Lasch, Thomas Cardon Rowe
  • Materials and methods for the intracellular delivery of substances
    Patent number: 6169078
    Abstract: The subject invention concerns novel materials and methods for the delivery of substances into cells. In a specific embodiment substances are delivered into cells using a novel class of lipid compounds. These compounds, cationic lipid compounds having a disulfide bond, can be complexed with DNA to be inserted into a cell in gene therapy. Once inside the cell, enzymes present within the cell cleave the disulfide bond and the DNA is released.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: January 2, 2001
    Assignee: University of Florida
    Inventors: Jeffrey Allen Hughes, Fuxng Tang
  • Methods for the intracellular delivery of substances
    Patent number: 6153434
    Abstract: The subject invention concerns novel materials and methods for the delivery of substances, such as DNA or polypeptides, into cells. In a specific embodiment, substances are delivered into cells using a novel class of lipid compounds. These compounds, cationic lipid compounds having a disulfide bond, can be complexed with DNA to be inserted into a cell in gene therapy. Once inside the cell, enzymes present within the cell cleave the disulfide bond and the DNA is released.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: November 28, 2000
    Assignee: University of Florida
    Inventors: Jeffrey Allen Hughes, Fuxng Tang
  • Materials and methods for intracellular delivery of biologically active molecules
    Patent number: 6090619
    Abstract: The subject invention finds utility in the area of gene therapy of diseases. More specifically, the invention concerns the making of a novel non-viral vector which can bind to desired DNA to form a combination useful to transfect diseased mitochondria of human or animal cells. The non-viral vector comprises a dequalinium salt subjected to standard liposome production procedures to obtain the vector named DQAsomes.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: July 18, 2000
    Assignee: University of Florida
    Inventors: Volkmar Weissig, Jeffrey Allen Hughes, Jurgen Lasch, Thomas Cardon Rowe