Abstract: A cryogenic probe, comprising: (a) a handle, (b) a shaft disposed distally on the handle, the shaft comprising a generally rigid proximal portion and a generally malleable distal portion, and (c) an active tip disposed distally on the shaft, where the shaft comprises a supply conduit configured to supply a cryogenic fluid to the active tip, an exhaust conduit configured to exhaust spent cryogenic fluid from the active tip, and a vacuum insulating layer disposed around the supply conduit and the exhaust conduit.

Abstract: Systems and method for applying roadway marking materials into a groove(s) in a roadway surface and/or forming a recessed groove(s) in a roadway surface. The systems and methods incorporate a contour sensor that provides real-time information of the marking material and/or groove. Based on the contour information, a marking material applicator can be aligned with a recessed groove in a roadway surface to ensure the marking material is applied within the confines of the groove. Alternatively, such contour information may be acquired during groove formation to ensure depth, tilt and/or bottom surface smoothness of the groove is within predetermined limits.

Abstract: Systems and method for applying roadway marking materials into a groove(s) in a roadway surface and/or forming a recessed groove(s) in a roadway surface. The systems and methods incorporate a contour sensor that provides real-time information of the marking material and/or groove. Based on the contour information, a marking material applicator can be aligned with a recessed groove in a roadway surface to ensure the marking material is applied within the confines of the groove. Alternatively, such contour information may be acquired during groove formation to ensure depth, tilt and/or bottom surface smoothness of the groove is within predetermined limits.

Abstract: Disclosed herein is method for conjugating a metal chelating agent to a functionalized dextran by reacting a chelator with an aminated dextran backbone, where the chelator comprises a one, and only one, derivatized carboxylic acid group to form a chelator-dextran complex. In certain aspects, the dextran-chelator complex is substantially free of intra- or intermolecular crosslinking. In certain aspects, the functionalized dextran is an amine dextran, an alkynyl dextran, or a thiol dextran. In exemplary implementations, the functionalized dextran is an amine dextran. In further embodiments, one and only one carboxylic acid group on the chelating agent is derivatized as a N-hydroxysuccinimide (NHS) ester.

Abstract: Disclosed herein is method for conjugating a metal chelating agent to a functionalized dextran by reacting a chelator with an aminated dextran backbone, where the chelator comprises a one, and only one, derivatized carboxylic acid group to form a chelator-dextran complex. In certain aspects, the dextran-chelator complex is substantially free of intra- or intermolecular crosslinking. In certain aspects, the functionalized dextran is an amine dextran, an alkynyl dextran, or a thiol dextran. In exemplary implementations, the functionalized dextran is an amine dextran. In further embodiments, one and only one carboxylic acid group on the chelating agent is derivatized as a N-hydroxysuccinimide (NHS) ester.

Abstract: A system for monitoring physical and/or environmental conditions during application of roadway marking tape. The system includes a data logging system that is operative to monitor one or more environmental parameters and geographical location during application of roadway marking tape. The data logging system generates a record of the parameters indexed to location. The record may be used to ensure application compliance and/or allow a user to alter one or more application parameters to ensure application compliance.

Abstract: Methods, compounds, and compositions of conjugating anthracyclines to a carbohydrate polymer backbone via click chemistry are provided. The conjugation of anthracyclines utilizing a reaction between a hydrazone azide moiety and alkyne moiety provide for compositions with less crosslinking, and thereby increasing the efficacy of targeted drug delivery. The methods further provide for controlled loading of anthracycline to a carbohydrate polymer backbone.

Abstract: A work vehicle includes a main frame. The main frame is configured to selectively receive one of a first type of power source and a second type of power source. The first type of power source is different from the second type of power source. A traction motor is connected to the main frame and is configured to be driven by the one of the first type of power source and the second type of power source. A wheel is connected to the main frame and is configured to be driven by the traction motor.

Abstract: Systems and method for applying roadway marking materials into a groove(s) in a roadway surface and/or forming a recessed groove(s) in a roadway surface. The systems and methods incorporate a contour sensor that provides real-time information of the marking material and/or groove. Based on the contour information, a marking material applicator can be aligned with a recessed groove in a roadway surface to ensure the marking material is applied within the confines of the groove. Alternatively, such contour information may be acquired during groove formation to ensure depth, tilt and/or bottom surface smoothness of the groove is within predetermined limits.

Abstract: The present disclosure relates to a system for monitoring physical and/or environmental conditions during application of roadway marking tape. The system includes a data logging system that is operative to monitor one or more environmental parameters and geographical location during application of roadway marking tape. The data logging system generates a record of the parameters indexed to location. The record may be used to ensure application compliance and/or allow a user to alter one or more application parameters to ensure application compliance.

Abstract: The present invention is directed to an trailer coupling assembly for connection to a trailer tongue. The trailer coupling assembly includes an attachment bracket configured to attach to a trailer tongue. A trailer coupler, which is configured to attach to a tow ball, is pivotally connected to the attachment bracket. The pivotal connection allows movement between the trailer coupler and the tongue of the trailer. An absorber further connects to the attachment bracket and the pivotally connected trailer coupler. The absorber dampens movement between the trailer tongue (e.g., attachment bracket) and the trailer coupler.

Abstract: A system and method (i.e., utilities) for calculating, in substantially real-time, the thickness of marking materials applied to roadway surfaces. The utilities utilize a linear position sensor to monitor positions of a shaft of a positive displacement paint pump. By monitoring the shaft position multiple times per stroke of the pump, pump displacement volumes may be calculated for intra-stroke movements of the pump. The pump displacement volumes permit calculating applied thickness of the marking materials in finer temporal increments than was previously possible.

Abstract: Systems and methods are provided for use with a thermoplastic road marking system (e.g., paint truck). The systems and methods control an insertion or replenishment rate of unmelted thermoplastic paint feed stock into a thermoplastic melter based, at least in part, on the rate that thermoplastic melt is being applied to a marking surface. By substantially matching the replenishment rate into the thermoplastic melter with the application rate, thermal variance within the thermoplastic melter is reduced, which improves the consistency of marking lines applied to surfaces.

Abstract: An automated tape applicator that applies pavement marking tape to a pavement surface. The automated tape applicator may include dual knives for cutting two or more patterns simultaneously, a hinged frame that permits an adhesion roller to be lifted off the ground when not in active use, an electronic clutch for selectively engaging a tape feed mechanism, a swiveling front tire, an automated controller for simultaneous application of multiple markings and accurate dimensioning, and/or replaceable knife inserts.

Abstract: An improved automated tape applicator that applies pavement marking tape to a pavement surface. The automated tape applicator may include dual knives for cutting two or more patterns simultaneously, a hinged frame that permits an adhesion roller to be lifted off the ground when not in active use, an electronic clutch for selectively engaging a tape feed mechanism, a swiveling front tire, an automated controller for simultaneous application of multiple markings and accurate dimensioning, and/or replaceable knife inserts.

Abstract: An improved automated tape applicator that applies pavement marking tape to a pavement surface. The automated tape applicator may include dual knives for cutting two or more patterns simultaneously, a hinged frame that permits an adhesion roller to be lifted off the ground when not in active use, an electronic clutch for selectively engaging a tape feed mechanism, a swiveling front tire, an automated controller for simultaneous application of multiple markings and accurate dimensioning, and/or replaceable knife inserts.

Abstract: An improved automated tape applicator that applies pavement marking tape to a pavement surface. The automated tape applicator may include dual knives for cutting two or more patterns simultaneously, a hinged frame that permits an adhesion roller to be lifted off the ground when not in active use, an electronic clutch for selectively engaging a tape feed mechanism, a swiveling front tire, an automated controller for simultaneous application of multiple markings and accurate dimensioning, and/or replaceable knife inserts.

Abstract: A system for controlling the mixing ratio of a multi-component mixture including a first pump connectable to a source of a first component and a second pump connectable to a source of a second component. The first and second pump being associated with at least one linear sensor for generating an output indicative of actual pump speed or shaft displacement of the pump. The system further includes a control circuit operative to utilize the output of the linear sensor of one of the pumps to generate a control signal for controlling the output of the other pump.