Patents by Inventor Jeffrey B. Adamo

Jeffrey B. Adamo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-PD-L1 antibodies and methods of making and using thereof
    Patent number: 11560431
    Abstract: The application provides the anti-PD-L1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: January 24, 2023
    Assignee: BAILI-BIO (CHENGDU) PHARMACEUTICAL CO., LTD.
    Inventors: Brian Kovacevich, Dong Xia, Anne E. Jensen, Jonathan K. Fallen, Blair Renshaw, Jeffrey B. Adamo, Phil Tan, Zeren Gao, Yi Zhu
  • Anti-PD-1 antibodies and methods of making and using thereof
    Patent number: 11466084
    Abstract: The application provides anti-PD-1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: October 11, 2022
    Assignee: SYSTIMMUNE, INC.
    Inventors: Brian Kovacevich, Dong Xia, Anne E. Jensen, Jonathan K. Fallen, Blair Renshaw, Jeffrey B. Adamo, Phil Tan, Zeren Gao, Yi Zhu
  • ANTI-PD-L1 ANTIBODIES AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20220002417
    Abstract: The application provides the anti-PD-L1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.
    Type: Application
    Filed: June 22, 2018
    Publication date: January 6, 2022
    Inventors: Brian KOVACEVICH, Dong XIA, Anne E. JENSEN, Jonathan K. FALLEN, Blair RENSHAW, Jeffrey B. Adamo, Phil TAN, Zeren GAO, Yi ZHU
  • Bispecific Tetravalent Antibodies and Methods of Making and Using Thereof
    Publication number: 20210277128
    Abstract: A bispecific tetravalent antibody comprising an IgG having a pair of heavy chains and a pair of light chains, and two scFv components being connected to either C or N terminals of the heavy or light chains. The bispecific tetravalent antibody may have a binding specificity for two different members of EGFR family.
    Type: Application
    Filed: January 7, 2021
    Publication date: September 9, 2021
    Inventors: Zeren Gao, Phil Tan, Brian R. Kovacevich, Blair R. Renshaw, Jeffrey B. Adamo, Nga Sze Amanda Mak, Shi Zhuo, Lan Chen, Yi Zhu
  • Bispecific tetravalent antibodies and methods of making and using thereof
    Patent number: 10919977
    Abstract: A bispecific tetravalent antibody comprising an IgG having a pair of heavy chains and a pair of light chains, and two scFv components being connected to either C or N terminals of the heavy or light chains. The bispecific tetravalent antibody may have a binding specificity for two different members of EGFR family.
    Type: Grant
    Filed: December 19, 2015
    Date of Patent: February 16, 2021
    Assignees: SYSTIMMUNE, INC., Sichuan Baili Pharmaceutical Co. Ltd.
    Inventors: Zeren Gao, Phil Tan, Brian R. Kovacevich, Blair R. Renshaw, Jeffrey B. Adamo, Nga Sze Amanda Mak, Shi Zhuo, Lan Chen, Yi Zhu
  • ANTI-PD-1 ANTIBODIES AND METHODS OF MAKING AND USING THEREOF
    Publication number: 20200157219
    Abstract: The application provides anti-PD-1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.
    Type: Application
    Filed: June 22, 2018
    Publication date: May 21, 2020
    Inventors: Brian KOVACEVICH, Dong XIA, Anne E. JENSEN, Jonathan K. FALLEN, Blair RENSHAW, Jeffrey B. Adamo, Phil TAN, Zeren GAO, Yi ZHU
  • Bispecific Tetravalent Antibodies and Methods of Making and Using Thereof
    Publication number: 20170073418
    Abstract: A bispecific tetravalent antibody comprising an IgG having a pair of heavy chains and a pair of light chains, and two scFv components being connected to either C or N terminals of the heavy or light chains. The bispecific tetravalent antibody may have a binding specificity for two different members of EGFR family.
    Type: Application
    Filed: December 19, 2015
    Publication date: March 16, 2017
    Inventors: Zeren Gao, Phil Tan, Brian R. Kovacevich, Blair R. Renshaw, Jeffrey B. Adamo, Nga Sze Amanda Mak, Shi Zhuo, Lan Chen