Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: The invention is a process for producing hydrocarbons from hydrogen and carbon monoxide by reacting hydrogen and carbon monoxide in the presence of a particulate solid catalyst and a substantially inert liquid medium. This reaction takes place in a reactor vessel adapted for the reaction of gases in the presence of a substantially inert liquid medium and a bed of solid particulate catalyst. The hydrogen gas and carbon monoxide gas are introduced at a plurality of locations within the reactor vessel. Bubbles of gas flow upward through the bed of solid catalyst particles and substantially inert liquid medium at sufficient velocity to expand the bed to a volume greater than its static volume. This velocity creates a turbulent reaction zone wherein liquid, gas, and solid catalyst are present and are in a state of motion.

Abstract: A method of catalytically hydroconverting a hydrocarbon feed stream containing a substantial quantity of components boiling above about 1000.degree. F. to convert a substantial portion thereof to components boiling below 1000.degree. F. is disclosed. More particularly, aromatic heavy oil additive, such as Heavy Cycle Gas Oil, is added to a heavy hydrocarbon feed stream and the stream is contacted with a solid catalyst and an oil-miscible metal naphthenate. The method disclosed herein advantageously substantially eliminates plugging of the hydroconversion reactor and minimizes the amount of insolubles in the total liquid product.

Abstract: Hydrodesulfurization and demetallalization of hydrocarbon charge is effected by hydrogenation in the presence of, as catalyst, a Group VI A metal and a non-noble Group VIII metal on a trimodal alumina support. The alumina support is formed by mixing at least two different finely divided charge aluminas each of which has a different pore mode.

Abstract: A method for preparing a catalyst composition is disclosed. In particular, a support is vacuum impregnated with at least one catalytically active element and, thereafter, the vacuum impregnated support is calcined to provide the catalyst composition. Preferably, the vacuum impregnation of the support is performed in a two-step sequence by (a) vacuum impregnating said support with said at least one element and, thereafter, calcining said support, and (b) vacuum impregnating said support with at least one other element.The catalyst composition prepared by the prescribed method is preferably used in a process for producing a mixture of lower aliphatic alcohols.

Abstract: A catalyst and method are provided for preparing a mixture of lower aliphatic alcohols by reacting a mixture of carbon monoxide and hydrogen under suitable conditions of temperature and pressure in the presence of a catalyst composition comprising palladium, an alkali metal or a mixture of alkali metals and a molybdenum promoter.