Abstract: A wire grid polarizer having a mirror layer is laminated with a colored film. The colored film provides a scratch protection of the mirror layer of the wire grid polarizer and provides a colored mirror appearance of an optical lens made with such wire grid polarizer. The colored film laminated wire grid polarizer shows different intensities between the transmitted and reflected colors when the wire grid polarizer is paired with a particular colored film. The wire grid polarizer is deposited on a structured surface of a photochromic film to form a photochromic wire grid polarizer.

Abstract: Ultrasound systems and devices are provided that facilitate positioning and orientation of an ultrasound beam relative to the vasculature of the patient for the detection of Doppler signals from vessels and the determination of a hemodynamic measure. In some example embodiments, a support structure, such as a patch, is provided that supports one or more ultrasound transducers relative to a coupling component, the support structure being removably attachable to a skin surface of a subject. Control and processing circuitry is connectable to the one or more ultrasound transducers to generate ultrasound beams, receive ultrasound signals, and process the received ultrasound signals to provide a Doppler signal and determine an associated hemodynamic measure. In some example implementations, the example embodiments disclosed herein may be employed to determine a hemodynamic measure associated with blood flow with major and/or minor vessels of the pedal arch, such as a pedal acceleration time.

Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.

Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.

Abstract: A light emitting ophthalmic lens in which a light source is incorporated into a lens. The light source may be configured to emit light within a specific wavelength, such as but not limited to a blue light having a wavelength of about 470 nanometers. The ophthalmic lens may include one or more light guiding elements for directing the light emitted from the light source onto a desired region of an eye, such as the outer areas of the retina. The light source may be attached to the ophthalmic lens or may be integrated therewith. The one or more light guiding elements may be configured to reflect, diffuse, disperse, defocus, and/or diffract the light from the light source towards the eye. A control unit may both power the light source and allow for programming various functions of the light source.

Abstract: A method for providing suggested text redactions for a document, includes receiving, from a user, the document comprising text; extracting the text from the document; parsing the extracted text into a plurality of identified text sentences; inputting the plurality of identified text sentences into one or more trained artificial intelligence models that have been trained on labeled text sentences to generate a set of suggested text redactions for the plurality of identified text sentences; and providing the set of suggested text redactions for the plurality of identified text sentences to the user.

Abstract: An ophthalmic lens including an embedded functional wafer which is coated on one or both sides with a coating layer and methods for fabricating the same. The coating layer may provide adhesion between the functional wafer and the surrounding resin used to form the lens. The coating layer may also protect the functional wafer from degradation during fabrication, such as due to chemical attack or exposure to heat during thermoforming. The coating layer may be applied to a flat functional sheet and then subsequently formed into a curvature to match the lens, or the coating layer may be applied to an already-curved functional wafer. The coating layer may comprise various compositions known to provide adhesion, protection from heat, and/or protection from chemicals.

Abstract: The present invention relates to a polarization filter for ophthalmic lenses. The polarization filter comprises a mesogen layer coated onto a retardation film, either directly or through an adhesive layer. The present invention further discloses that the polarization filter formed by employing a thin film or sheet, having a defined level of retardation between the light source and the mesogen layer, for example, a cholesteric mesogen layer, the multilayered laminate structure demonstrates linear polarization of the light transmitted through the mesogen laminate structure, and, hence, can be used in ophthalmic lenses, e.g. spectacle or eyeglass lenses. The polarization filter enhances the performance by allowing transmission of the polarization filter closer to the theoretical maximum transmission.

Abstract: Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Abstract: Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.

Abstract: A room air purifier has a body with a frame at least partially defining an interior chamber and an opening to the chamber. A purification mechanism in the chamber includes one or more filters and one or more blowers. A panel is configured to removably mount to the body and cover the opening to the chamber. A base mounted to the body, and each leg of a set of legs is mounted to the base. A nonwoven fabric portion covers at least part of the body. The blower when activated generates an inflow through the nonwoven fabric portion and a filter, and an outflow though the body, all while hidden from view in what to an observer looks like an article of furniture.

Abstract: An example of a flow cell includes a substrate; a first primer set attached to a first region on the substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; and a second primer set attached to a second region on the substrate, the second primer set including a cleavable first primer and an un-cleavable second primer.

Abstract: The present disclosure is directed to a method and system to develop finite element (FE) models of as-manufactured turbomachinery blades using a combination of optical topography measurements, mesh morphing and strain gauge measurements. The method and system improves strain gauge to blade tip timing correlation using as-manufactured blade dimensions with finite element modeling.

Abstract: An ophthalmic article having a coating system which provides antireflective and easy clean properties to the ophthalmic article. The coating system includes alternating layers of low refractive index metal oxide and high refractive index metal oxynitrides and corresponding high refractive index metal oxides. The coating system provides favorable surface energy to the ophthalmic article when at least one layer of the high refractive index metal oxynitride is encapsulated between two layers of low refractive index metal oxide.

Abstract: Systems and devices are provided for generating focused ultrasound pulses based on a transducer assembly having a piezoelectric layer coupled to an acoustic lens. In some example embodiments, the piezoelectric layer is a composite piezoelectric material having an acoustic impedance configured to match the acoustic impedance of the acoustic lens. The acoustic lens may be formed from aluminum, or an alloy thereof, and may have a distal surface having a non-spherical profile for producing a focal region that is smaller than an equivalent spherical lens. The acoustic lens may have an f-number less than unity. In some embodiments, the acoustic lens is coated with a polymer acoustic impedance matching layer that is compatible with deposition via chemical vapor deposition, such as a p-xylylene based polymer. In some embodiments, the acoustic lens is formed from aluminum or an alloy thereof, and the polymer acoustic impedance matching layer is a Parylene layer.

Abstract: Provided are enriched tissue extracts and methods of making and using such extracts. The enriched tissue extracts contain biologically active components. Some extracts produced by the methods contain extracellular vesicles. The methods can involve administering a physical stress on a biological sample comprising live cells or otherwise stimulating the live cells of the biological sample. Also contemplated are methods in which the biological sample does not contain live cells. The biological sample is incubated in an extraction solution for a period of time sufficient for extraction of biologically active components from the biological sample. Methods of using the extracts, or extracellular vesicles isolated therefrom, therapeutically and for in vitro purposes are also provided.

Abstract: Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Abstract: A vehicle guidance system and method includes at least one guidance sensor configured to mount on or adjacent to a pantograph along a lateral width of the pantograph. The pantograph installs on a vehicle and conducts electrical energy from a conductive pathway as the vehicle travels along a route. The vehicle guidance system and method includes a controller that receives one or more sensor signals generated by the at least one guidance sensor and determines a lateral position of the conductive pathway relative to the pantograph based on the one or more sensor signals.

Abstract: A fuel cell system includes a fuel cell. The fuel cell includes an anode having an anode inlet configured to receive anode feed gas, and an anode outlet configured to output anode exhaust. The fuel cell further includes a cathode having a cathode inlet and a cathode outlet. The fuel cell system further includes an anode blower configured to receive the anode exhaust and output a higher-pressure anode exhaust. The fuel cell system further includes an anode blower recycle line configured to receive a portion of the higher-pressure anode exhaust downstream from the anode blower and to output the portion of the higher-pressure anode exhaust upstream from the anode blower. The fuel cell system further includes a first valve disposed in the blower recycle line, the first valve configured to open when the anode of the fuel cell is under-pressurized.

Abstract: This technology relates to rendering content from discrete applications. In this regard, one or more computing devices may receive a global scene graph containing resources provided by two or more discrete processes, wherein the global scene graph is instantiated by a first process of the two or more discrete processes. The one or more computing devices may render and output for display, the global scene graph in accordance with the resources contained there.