Patents by Inventor Jeffrey Bruce SMALL

Jeffrey Bruce SMALL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRODRUG COMPOUNDS ACTIVATED BY AKR1C3 AND THEIR USE FOR TREATING HYPERPROLIFERATIVE DISORDERS
    Publication number: 20210115002
    Abstract: AKR1C3-activated prodrugs of Formula (I), pharmaceutical compositions comprising prodrugs of Formula (I), and their use in the treatment of hyperproliferative diseases such as cancer and for cell ablation. The compounds of the invention are able to penetrate neoplasm tissue and be selectively reduced to an active (cytotoxic) form by contact with an AKR1C3 enzyme found in the neoplasm. This active form is therefore able to ablate AKR1C3-expressing target cells of the neoplasm and therefore has particular utility in the treatment of cancer and other hyperproliferative disorders.
    Type: Application
    Filed: March 25, 2019
    Publication date: April 22, 2021
    Inventors: Amir ASHOORZADEH, Christopher Paul GUISE, Adam Vorn PATTERSON, Jeffrey Bruce SMALL