Abstract: Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.

Abstract: The present disclosure relates to aqueous oral solutions comprising baclofen. In one embodiment, the aqueous oral solutions comprise a buffer comprising citric acid, a salt of citric acid, or any combination thereof, and are stored at from about 2° C. to about 8° C. The present disclosure also relates to buffer free aqueous oral solutions comprising baclofen. Additionally, the present disclosure relates to an assay for determining the amount of an impurity, 4-(3-carboxymethyl)-3-hydroxy-2,5-dioxopyrrolidin-1-yl)-3-(4-chlorophenyl)butanoic acid, in a baclofen containing solution, and to methods of treatment using such aqueous oral solutions.

Abstract: Systems and methods for predictive analytics may make innovation success easy to manage by predicting the best process and teams to help teams discover if their ideas can reach ideal outcomes. Leadership may make a portfolio of investments in opportunity areas. Each opportunity area's funds may be broken down into different bets. Each bet fund may have success criteria to determine if an opportunity can continue to the next stage of funding. Each success metric may have blocks that help take ideas to success. Systems and methods may recommend the best block path to success for each idea. Blocks may be recommended based on context including, but not limited to, progress, goals, priorities, team dynamics, and skills. These systems and methods also may empower people to drive success, while engaging interests, saving hours, and eliminating wrong work. Good decisions may be made to maximize ROI, thereby creating innovation success.

Abstract: The present teachings include techniques for lifting a user (e.g., a person having an injury or a physical disability) onto playground equipment. One such technique includes coupling a lifting device to playground equipment and positioning a user on a first platform of the lifting device. Sub-platforms of the lifting device may be disposed between the first platform and an elevated engagement area of the playground equipment, where the sub-platforms define stairs between the first platform and the engagement area. An actuator may move the first platform upward toward the engagement area along a z-axis, and, either via the actuator or movement of the first platform, each of the plurality of sub-platforms may also move along the z-axis to form a substantially planar pathway between the first platform and the playground equipment at the elevated height.

Abstract: The present disclosure relates to aqueous oral solutions comprising baclofen. In one embodiment, the aqueous oral solutions comprise a buffer comprising citric acid, a salt of citric acid, or any combination thereof, and are stored at from about 2° C. to about 8° C. The present disclosure also relates to buffer free aqueous oral solutions comprising baclofen. Additionally, the present disclosure relates to an assay for determining the amount of an impurity, 4-(3-carboxymethyl)-3-hydroxy-2,5-dioxopyrrolidin-1-yl)-3-(4-chlorophenyl)butanoic acid, in a baclofen containing solution, and to methods of treatment using such aqueous oral solutions.

Abstract: The present disclosure relates to aqueous oral solutions comprising baclofen. In one embodiment, the aqueous oral solutions comprise a buffer comprising citric acid, a salt of citric acid, or any combination thereof, and are stored at from about 2° C. to about 8° C. The present disclosure also relates to buffer free aqueous oral solutions comprising baclofen. Additionally, the present disclosure relates to an assay for determining the amount of an impurity, 4-(3-carboxymethyl)-3-hydroxy-2,5-dioxopyrrolidin-1-yl)-3-(4-chlorophenyl)butanoic acid, in a baclofen containing solution, and to methods of treatment using such aqueous oral solutions.

Abstract: The invention provides pharmaceutical preparations of celecoxib in suspension, solution, and combination thereof for oral administration. Insolubility of celecoxib in water is overcome in embodiments of the invention by employing co-solvents, and liquid dosage forms having celecoxib in solution at concentrations up to 10 mg/ml are provided. Manufacturing methods for celecoxib suspensions are included in the present disclosure.

Abstract: Dry powder tannate compositions containing bioactive agents, tannic acid, dispersants, and viscosity modifying agents are disclosed. Specifically, the bioactive agents are antihistamines, decongestants, antitussives, and anticholinergics. The dry powder formulations can further include pharmaceutically acceptable excipients. The dry powder formulations exhibit increased stability for extended shelf life. Bioactive agent tannate salts remain suspended for at least two weeks following formation of the suspension in a pharmaceutically acceptable aqueous liquid.

Abstract: Methods and processes are disclosed for calibrating optoelectronic devices, such as optoelectronic transceivers and optoelectronic receivers, based upon an avalanche photodiode breakdown voltage. In general, the method involves adjusting a reverse-bias voltage of the avalanche photodiode until avalanche breakdown of the avalanche photodiode occurs. An optimized APD reverse-bias voltage is then determined by reducing the reverse-bias voltage at which avalanche breakdown occurs by a predetermined offset voltage. This process is performed at a variety of different temperatures. Information concerning each temperature and the corresponding optimized APD reverse-bias voltage is stored in a memory of the optoelectronic device.

Abstract: A controller for controlling the reverse-bias voltage of an avalanche photodiode in a transceiver or receiver. The controller includes memory for storing information related to the avalanche photodiode, and analog to digital conversion circuitry for receiving an analog signal corresponding to the temperature of the avalanche photodiode, converting the received analog signal into a digital value, and storing the digital value in a predefined location within the memory. Control circuitry in the controller controls the operation of the avalanche photodiode and a temperature lookup table store in the memory. A serial interface enables a host device to read from and write to locations within the memory. The invention also controls the reverse-bias voltage of an avalanche photodiode in a transceiver or receiver.

Abstract: An apparatus and method are provided for setting the AC and DC bias levels of a laser diode in an optoelectronic transceiver so as to control the device's extinction ratio. An optical output of the transceiver is looped back to an optical input of the transceiver. The method includes setting a DC bias level for the laser diode, setting an AC bias level for the laser diode to each of a predefined sequence of AC bias level settings, and receiving from the transceiver a sequence of optical output power measurements, the sequence of optical output power measurements including an average optical output power measurement corresponding to each of the AC bias level settings in the predefined sequence. From the received sequence of optical output power measurements preferred AC and DC bias level settings are determined and stored in the transceiver so as to control the AC and DC bias levels of the laser diode.

Abstract: A reconfigurable distributed signal processing system uses an object-oriented component-framework architecture in which the system permits large-scale software reuse. This is accomplished by the use of a framework and a number of reusable, reconfigurable software components that are hardware independent. The components communicate over a data fabric using open published APIs over one or more data communications mechanisms. Interchangeable software components are used that perform the signal processing. Interchangeability is assured by each component meeting a required interface in which the component inherits the required interface elements from component base classes. This use of inheritance to assure interface compliance also reduces the programming work required for developing a component. Most importantly, the interchangeable components are reconfigurable into various systems at runtime, as defined by a Plan.

Abstract: A method for operating a system having a plurality of software components includes an observation tool in the form of a control panel that is first attached to one of the components. The control panel then configures itself based on information derived from the component. The configuration consists of the discovery of all the externally accessible attributes of the component and the properties of the attributes such as name, data type, legal value and the like. The user may then effect changes in the component using this common mechanism. Since components have a common interface, an observation tool may interact with any component.

Abstract: An apparatus and method are provided for setting the AC and DC bias levels of a laser diode in an optoelectronic transceiver so as to control the device's extinction ratio. An optical output of the transceiver is looped back to an optical input of the transceiver. The method includes setting a DC bias level for the laser diode, setting an AC bias level for the laser diode to each of a predefined sequence of AC bias level settings, and receiving from the transceiver a sequence of optical output power measurements, the sequence of optical output power measurements including an average optical output power measurement corresponding to each of the AC bias level settings in the predefined sequence. From the received sequence of optical output power measurements preferred AC and DC bias level settings are determined and stored in the transceiver so as to control the AC and DC bias levels of the laser diode.

Abstract: A controller for controlling the reverse-bias voltage of an avalanche photodiode in a transceiver or receiver. The controller includes memory for storing information related to the avalanche photodiode, and analog to digital conversion circuitry for receiving an analog signal corresponding to the temperature of the avalanche photodiode, converting the received analog signal into a digital value, and storing the digital value in a predefined location within the memory. Control circuitry in the controller controls the operation of the avalanche photodiode in accordance with the digital value corresponding to the temperature of the avalanche photodiode and a temperature lookup table stored in the memory. A serial interface is provided to enable a host device to read from and write to locations within the memory.

Abstract: In the on-site manufacture of nipples of relatively short length for joining pipe sections in a conduit system, spacer pins and spacers are selected to achieve a user-determined displacement between an end stop and cutting element of a pipe groover used for cutting external annular grooves along the pipe stock. The use of the spacer pins and spacers allows the grooving tool to be displaced at measured displacements from a selected end of the pipe stock while providing a visual gauge to the user of such displacement.In the fabrication of these nipples, the end stop/yoke is positioned abutting a selected end of the pipe stock thereby positioning the cutting element where a first groove is cut. Upon selection of a combination of spacer pins and/or spacers the end stop is again positioned to abut the selected end of the pipe stock thereby positioning the cutting element where a second groove is cut.