Abstract: A monolithic implantable device for delivery of an antibody is provided. The implantable device comprises a polymer matrix within which is dispersed a pharmaceutical formulation that includes one or more therapeutic agents and optionally, one or more excipients. The therapeutic agents contain an antibody and the polymer matrix contains a hydrophobic polymer. Within a time period of 35 days, the device exhibits a cumulative weight-based release ratio of the antibody of from about 20% to about 60%.

Abstract: An implantable device for delivery of a tyrosine kinase inhibitor is provided. The device comprises a core defining an outer peripheral surface. The core comprises a core polymer matrix within which is dispersed a tyrosine kinase inhibitor. The polymer matrix contains an ethylene vinyl acetate copolymer.

Abstract: An implantable device for prohibiting and/or treating an inflammatory eye condition is provided. The device comprises a core defining an outer peripheral surface. The core comprises a core polymer matrix within which is dispersed at least a steroidal agent, the polymer matrix containing an ethylene vinyl acetate copolymer.

Abstract: An implantable medical device is provided. The device comprises a drug release layer, wherein the drug release layer comprises a naked nucleic acid dispersed within a polymer matrix. The polymer matrix includes an ethylene vinyl acetate copolymer and has a melting temperature of from about 20° C. to about 100° C. as determined in accordance with ASTM D3418-15 and a melt flow index of from about 0.2 to about 100 gram per 10 minutes as determined in accordance with ASTM D1238-20 at a temperature of 190° C. and a load of 2.16 kilograms.

Abstract: An implantable device for delivery of a macromolecular drug compound is provided. The device comprises a core having an outer surface and a membrane layer positioned adjacent to the outer surface of the core. The core comprises a core polymer matrix within which is dispersed a drug compound having a molecular weight of about 0.5 kDa or more, the polymer matrix containing a hydrophobic polymer. Further, the membrane layer comprises a plurality of water-soluble particles distributed within a membrane polymer matrix containing an ethylene vinyl acetate copolymer, wherein the water-soluble particles have a D50 particle size of about 150 micrometers or less and contain a non-polymeric, hydroxy-functional compound.

Abstract: An implantable medical device is provided. The device comprises a drug release layer, wherein the drug release layer comprises a naked nucleic acid dispersed within a polymer matrix. The polymer matrix includes an ethylene vinyl acetate copolymer and has a melting temperature of from about 20° C. to about 100° C. as determined in accordance with ASTM D3418-15 and a melt flow index of from about 0.2 to about 100 gram per 10 minutes as determined in accordance with ASTM D1238-20 at a temperature of 190° C. and a load of 2.16 kilograms.

Abstract: An implantable medical device is provided. The device comprises a drug release layer, wherein the drug release layer contains particles dispersed within a polymer matrix. The lipid particles include a carrier component that contains a carrier (e.g., peptide, protein, carbohydrate, lipid, polymer, etc.) and encapsulates a nucleic acid, wherein the polymer matrix includes an ethylene vinyl acetate copolymer. The ratio of the melting temperature of the ethylene vinyl acetate copolymer to the melting temperature of the carrier is about 2° C./° C. or less.

Abstract: A medical tube that contains a polymer composition that is generally flexible and biocompatible is provided. The polymer composition contains at least one ethylene vinyl acetate polymer and at least one viscoelastic additive. By selectively controlling specific aspects of the ethylene vinyl acetate polymer (e.g., vinyl acetate content, melt flow index, density, etc.), the viscoelastic additive, and the manner in which they are blended, the resulting composition can exhibit a reduced tendency to kink when formed into the medical tube.

Abstract: A medical tube that contains a polymer composition that is generally flexible and biocompatible is provided. The polymer composition contains at least one ethylene vinyl acetate polymer and at least one viscoelastic additive. By selectively controlling specific aspects of the ethylene vinyl acetate polymer (e.g., vinyl acetate content, melt flow index, density, etc.), the viscoelastic additive, and the manner in which they are blended, the resulting composition can exhibit a reduced tendency to kink when formed into the medical tube.

Abstract: A medical tube that contains a polymer composition that is generally flexible and biocompatible is provided. The polymer composition contains at least one ethylene vinyl acetate polymer and at least one viscoelastic additive. By selectively controlling specific aspects of the ethylene vinyl acetate polymer (e.g., vinyl acetate content, melt flow index, density, etc.), the viscoelastic additive, and the manner in which they are blended, the resulting composition can exhibit a reduced tendency to kink when formed into the medical tube.

Abstract: A tie layer adhesive composition for multilayer structures, wherein the tie layer is composed of a graft polyolefin and a hybrid polyolefin.

Abstract: Disclosed is a multilayer film. The multilayer film has the general structure of A/B/A/C or B/A/B/C, wherein A is a nucleated high density polyethylene (HDPE) layer, B is a single or multilayer structure, and C is a seal layer. Adding a nucleating agent to HDPE improves the water vapor barrier property of the HDPE layer and the multilayer film, but it also causes the multilayer film to curl in the conventional multilayer film structures. The invention provides a multilayer film, which includes at least one layer of nucleated HDPE, with reduced or eliminated curling while retaining high water vapor barrier.

Abstract: Generally, controlled release insect repellent materials include at least one polymer selected from the group consisting of an ethylene copolymer, an ethyl cellulose, a thermoplastic polyurethane, and any combination thereof and at least one insect repellent and may optionally include at least one insect repellent synergist, at least one additive, at least one additional polymer, and any combination thereof. Further, controlled release insect repellent materials may be used to form articles or products with long-term efficacy.

Abstract: A tie layer adhesive composition for multilayer structures, wherein the tie layer is composed of a graft polyolefin and a hybrid polyolefin.

Abstract: A polyethylene composition comprising 0.01% to 1% by weight of at least one platelet-shaped nano boehmite nucleator, wherein the platelet-shaped nano boehmite nucleator comprises at least 70% by weight of Al2O3 and has a crystallite size of at least 5 nm, and the polyethylene composition comprises a density greater than 0.94 g/cm3, a melt index (MI2) ranging from equal to or greater than 0.3 g/10 min. up to equal to or less than 3 g/10 min., and a peak crystallization temperature (Tc) value determined according to ASTM D 3418, with an annealing temperature of 160° C. and a cooling rate of 10° C./min., that corresponds to formula (I): Tc?(A*density)?73.5° C.??(I) where A is 200 cm3-° C./g, Tc is in units of ° C., and density is in units of g/cm3.

Abstract: Disclosed is a colored high density polyethylene composition. The composition comprises a high density polyethylene, phthalocyanine blue, and talc. The composition exhibits reduced warpage in molded articles compared to those which do not contain talc. The composition is useful for injection molding and many other applications where a blue color is needed and low warpage is desired.

Abstract: A polyethylene composition comprising 0.01% to 1% by weight of at least one platelet-shaped nano boehmite nucleator, wherein the platelet-shaped nano boehmite nucleator comprises at least 70% by weight of Al2O3 and has a crystallite size of at least 5 nm, and the polyethylene composition comprises a density greater than 0.94 g/cm3, a melt index (MI2) ranging from equal to or greater than 0.3 g/10 min. up to equal to or less than 3 g/10 min., and a peak crystallization temperature (Tc) value determined according to ASTM D 3418, with an annealing temperature of 160° C. and a cooling rate of 10° C./min., that corresponds to formula (I): Tc?(A*density)?73.5° C.??(I) where A is 200 cm3-° C./g, Tc is in units of ° C., and density is in units of g/cm3.

Abstract: Disclosed is a multilayer film. The multilayer film has the general structure of A/B/A/C or B/A/B/C, wherein A is a nucleated high density polyethylene (HDPE) layer, B is a single or multilayer structure, and C is a seal layer. Adding a nucleating agent to HDPE improves the water vapor barrier property of the HDPE layer and the multilayer film, but it also causes the multilayer film to curl in the conventional multilayer film structures. The invention provides a multilayer film, which includes at least one layer of nucleated HDPE, with reduced or eliminated curling while retaining high water vapor barrier.

Abstract: Disclosed is a colored high density polyethylene composition. The composition comprises a high density polyethylene, phthalocyanine blue, and talc. The composition exhibits reduced warpage in molded articles compared to those which do not contain talc. The composition is useful for injection molding and many other applications where a blue color is needed and low warpage is desired.

Abstract: Disclosed is a multimodal, high density, homopolyethylene barrier resin. The resin is preferably made by a multistage process. The process comprises a first stage in which ethylene is homopolymerized in the presence of a Ziegler-Natta catalyst, organoaluminum cocatalyst, alkoxysilane modifier, and hydrogen. The reaction mixture from the first stage is devolatilized to remove all or substantially all of the hydrogen. The polymerization continues in a second stage wherein ethylene is added to the devolatilized reaction mixture to produce the barrier resin. The barrier resin provides films with improved barrier properties.