Patents by Inventor Jeffrey C. Henise
Jeffrey C. Henise has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230135347Abstract: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.Type: ApplicationFiled: September 7, 2022Publication date: May 4, 2023Applicant: ProLynx LLCInventors: Gary W. ASHLEY, Daniel V. SANTI, Jeffrey C. HENISE
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Patent number: 11454861Abstract: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.Type: GrantFiled: August 30, 2019Date of Patent: September 27, 2022Assignee: ProLynx LLCInventors: Gary W. Ashley, Daniel V. Santi, Jeffrey C. Henise
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Publication number: 20220265873Abstract: Methods for the steam sterilization of hydrogels crosslinked with a beta-eliminative linker without the drawback of significant degradation are provided.Type: ApplicationFiled: August 7, 2020Publication date: August 25, 2022Applicant: ProLynx LLCInventors: Jeffrey C. HENISE, Gary W. ASHLEY, Brian YAO
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Patent number: 11181803Abstract: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.Type: GrantFiled: January 15, 2019Date of Patent: November 23, 2021Assignee: ProLynx LLCInventors: Gary W. Ashley, Daniel V. Santi, Jeffrey C. Henise
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Patent number: 11179470Abstract: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.Type: GrantFiled: January 15, 2019Date of Patent: November 23, 2021Assignee: ProLynx LLCInventors: Gary W. Ashley, Daniel V. Santi, Jeffrey C. Henise
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Publication number: 20200164083Abstract: Extended-release conjugates of stabilized GLP-1 agonists balance agonist stability with release rates to provide long lasting administration to treat diabetes and related conditions on once-a-month or less frequent dosing schedules.Type: ApplicationFiled: March 16, 2017Publication date: May 28, 2020Applicant: ProLynx LLCInventors: Eric L. SCHNEIDER, Brian HEARN, Jeffrey C. HENISE, Gary W. ASHLEY, Daniel V. SANTI
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Publication number: 20200054756Abstract: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.Type: ApplicationFiled: August 30, 2019Publication date: February 20, 2020Applicant: ProLynx LLCInventors: Gary W. ASHLEY, Daniel V. SANTI, Jeffrey C. HENISE
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Patent number: 10398779Abstract: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.Type: GrantFiled: April 12, 2017Date of Patent: September 3, 2019Assignee: ProLynx LLCInventors: Gary W. Ashley, Daniel V. Santi, Jeffrey C. Henise
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Publication number: 20190209692Abstract: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.Type: ApplicationFiled: January 15, 2019Publication date: July 11, 2019Applicant: ProLynx LLCInventors: Gary W. ASHLEY, Daniel V. SANTI, Jeffrey C. HENISE
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Publication number: 20190209691Abstract: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.Type: ApplicationFiled: January 15, 2019Publication date: July 11, 2019Applicant: ProLynx LLCInventors: Gary W. ASHLEY, Daniel V. SANTI, Jeffrey C. HENISE
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Publication number: 20170312368Abstract: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.Type: ApplicationFiled: April 12, 2017Publication date: November 2, 2017Applicant: ProLynx LLCInventors: Gary W. ASHLEY, Daniel V. SANTI, Jeffrey C. HENISE
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Patent number: 9649385Abstract: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.Type: GrantFiled: September 7, 2012Date of Patent: May 16, 2017Assignee: ProLynx LLCInventors: Gary W. Ashley, Daniel V. Santi, Jeffrey C. Henise
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Publication number: 20150352246Abstract: The invention provides sealants wherein biodegradable hydrogels that do not otherwise comprise protein-reactive groups for binding to membranes or tissue are provided said groups optionally through a linker. The linker may be biodegradable and may be biodegradable by an elimination reaction. The invention also provides multilayer gels for drug delivery wherein a porous gel in contact with a tissue or organ to which the drug is to be delivered is protected by a microporous layer from the surrounding bodily fluid.Type: ApplicationFiled: January 22, 2014Publication date: December 10, 2015Applicant: Prolynx LLCInventors: Jeffrey C. HENISE, Gary W. ASHLEY, Daniel V. SANTI
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Publication number: 20140288190Abstract: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.Type: ApplicationFiled: September 7, 2012Publication date: September 25, 2014Applicant: ProLynx LLCInventors: Gary W. Ashley, Daniel V. Santi, Jeffrey C. Henise