Abstract: The present invention relates to a method for suppressing infectivity of HIV which includes contacting the HIV or a cell targeted by HIV with an effective amount of a thrombospondin or a thrombospondin analog. Other aspects of the invention relate to contraceptives, pharmaceutical compositions, and non-contraceptive prophylactic devices that include a carrier and a thrombospondin or a thrombospondin analog. Methods of inhibiting HIV infection in a patient, blocking HIV binding to a cell, blocking chemokine binding to its receptor, and treating or preventing inflammatory states in a patient are also disclosed.

Abstract: The invention provides a purified protein substantially free of other human proteins, having an amino acid sequence sufficiently duplicative of the sequence: ##STR1## such that the protein is capable of selectively suppressing the immune function of T-helper cells.

Abstract: A human T cell hybridoma comprising the product of:(A) fusion of:(i) a T cell from a patient with ARC or AIDS, wherein said T cell secretes an SSF capable of specifically inhibiting T cell-dependent responses while leaving other immune functions intact, and(ii) a human T cell line,followed by(B) selection from the product of (A) of a human T cell hybridoma which secretes an SSF capable of specifically inhibiting T cell-dependent responses while leaving other immune functions intact.