Patents by Inventor Jeffrey C. Wang
Jeffrey C. Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200323786Abstract: Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited in by short in vivo half-lives and a narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. A nanoscale controlled release system (degradable protein nanocapsule) is provided via in-situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes are achieved with the growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 (BMP-2) nanocapsules.Type: ApplicationFiled: May 24, 2017Publication date: October 15, 2020Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNIVERSITY OF SOUTHERN CALIFORNIA, TIANJIN UNIVERSITYInventors: Yunfeng Lu, Jeffrey C. Wang, Haijun Tian, Juanjuan Du, Jing Wen, Yang Liu, Xubo Yuan
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Publication number: 20190254720Abstract: Laminoplasty plates are engageable to at least one portion of a divided lamina to maintain a desired spacing relative to the spinal canal. The laminoplasty plates include a spacer portion having a first end and a second end that spans a gap formed by at least one of a divided lamina portion. The laminoplasty plates can include a lamina engagement portion at one end for engagement with the divided lamina portion.Type: ApplicationFiled: April 30, 2019Publication date: August 22, 2019Applicant: WARSAW ORTHOPEDIC, INC.Inventors: William B. Null, Robert W. Weakley, Gregory C. Marik, John G. Heller, Jeffrey C. Wang
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Patent number: 10314621Abstract: Laminoplasty plates are engageable to at least one portion of a divided lamina to maintain a desired spacing relative to the spinal canal. The laminoplasty plates include a spacer portion having a first end and a second end that spans a gap formed by at least one of a divided lamina portion. The laminoplasty plates can include a lamina engagement portion at one end for engagement with the divided lamina portion.Type: GrantFiled: January 24, 2014Date of Patent: June 11, 2019Assignee: Warsaw Orthopedic, Inc.Inventors: William B. Null, Robert W. Weakley, Gregory C. Marik, John G. Heller, Jeffrey C. Wang
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Patent number: 9855368Abstract: A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.Type: GrantFiled: March 6, 2015Date of Patent: January 2, 2018Assignees: The Regents of the University of California, Department of Veterans AffairsInventors: Samuel S. Murray, Elsa J. Murray, Jeffrey C. Wang, Keyvan Behnam
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Patent number: 9610320Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.Type: GrantFiled: June 5, 2015Date of Patent: April 4, 2017Assignees: REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Samuel S. Murray, Elsa J. Brochmann-Murray, Keyvan Behnam, Jeffrey C. Wang
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Publication number: 20150305914Abstract: A multi-layer cast for immobilizing a body member of a patient includes a hydrophobic sleeve having a shape configured to be applied over the body member and substantially conform to the shape of the body member, and a moldable layer configured to be positioned around said sleeve and hardened to conform to the shape of said body member adjacent said sleeve is presented. The hydrophobic sleeve includes fibers configured to wick moisture outward away from the body member, and the moldable layer includes a network of pores that extend through the moldable layer such that the pores are configured to contact the hydrophobic sleeve to promote flow of moisture from the hydrophobic sleeve outward through the moldable layer. An external removable wrap may also be detachably disposed around the moldable layer for additional support and moisture wicking.Type: ApplicationFiled: April 30, 2015Publication date: October 29, 2015Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Benjamin M. Wu, Jeffrey C. Wang, Emily W. Loughran
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Publication number: 20150265673Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.Type: ApplicationFiled: June 5, 2015Publication date: September 24, 2015Inventors: Samuel S. Murray, Elsa J. Brochmann-Murray, Keyvan Behnam, Jeffrey C. Wang
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Publication number: 20150246158Abstract: A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.Type: ApplicationFiled: March 6, 2015Publication date: September 3, 2015Inventors: Samuel S. Murray, Elsa J. Murray, Jeffrey C. Wang, Keyvan Behnam
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Patent number: 9050300Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.Type: GrantFiled: April 5, 2013Date of Patent: June 9, 2015Assignees: The Regents of The University of California, The United States of America Represented by The Department of Veterans AffairsInventors: Samuel S. Murray, Elsa J. Brochmann-Murray, Keyvan Behnam, Jeffrey C. Wang
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Patent number: 8962569Abstract: Provided herein is tumor suppression composition and methods of making and using the same.Type: GrantFiled: May 25, 2011Date of Patent: February 24, 2015Assignees: The Regeants of the University of California, The United States of America as Represented by the Department of Veterans AffairsInventors: Samuel S. Murray, Elsa J. Murray, Jeffrey C. Wang
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Publication number: 20140178346Abstract: Cell compositions for tissue engineering are provided which contain a population of autologous, minimally passaged dermal fibroblasts in combination with a tissue engineering matrix or scaffold, or material forming a matrix or scaffold. In one embodiment, the population of fibroblasts is genetically engineered to secrete a therapeutic protein in an amount effective to induce tissue growth or tissue repair when the cell composition is transplanted into a subject in need thereof. For example, the therapeutic protein can be a bone morphogenic protein when the tissue to be treated is bone tissue. A preferred bone morphogenic protein is BMP-2.Type: ApplicationFiled: December 24, 2013Publication date: June 26, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: James A. Byrne, Jeffrey C. Wang
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Publication number: 20140135845Abstract: Laminoplasty plates are engageable to at least one portion of a divided lamina to maintain a desired spacing relative to the spinal canal. The laminoplasty plates include a spacer portion having a first end and a second end that spans a gap formed by at least one of a divided lamina portion. The laminoplasty plates can include a lamina engagement portion at one end for engagement with the divided lamina portion.Type: ApplicationFiled: January 24, 2014Publication date: May 15, 2014Applicant: WARSAW ORTHOPEDIC, INC.Inventors: William B. Null, Robert W. Weakley, Gregory C. Marik, John G. Heller, Jeffrey C. Wang
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Publication number: 20130303449Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.Type: ApplicationFiled: April 5, 2013Publication date: November 14, 2013Inventors: Samuel S. MURRAY, Elsa J. BROCHMANN-MURRAY, Keyvan BEHNAM, Jeffrey C. WANG
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Publication number: 20130143811Abstract: Provided herein is tumor suppression composition and methods of making and using the same.Type: ApplicationFiled: May 25, 2011Publication date: June 6, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Samuel S. Murray, Elsa J. Murray, Jeffrey C. Wang
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Patent number: 8415302Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.Type: GrantFiled: December 26, 2007Date of Patent: April 9, 2013Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans AffairsInventors: Samuel S. Murray, Elsa J. Brochmann-Murray, Keyvan Behnam, Jeffrey C. Wang
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Patent number: 8193312Abstract: A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.Type: GrantFiled: November 16, 2007Date of Patent: June 5, 2012Assignees: The Regents of the University of California, The United States of America as represented by the Department of Veterans AffairsInventors: Samuel S. Murray, Elsa J. Murray, Jeffrey C. Wang, Keyvan Behnam
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Patent number: 8182518Abstract: A cervical bone plate includes a graft window that allows access to and/or visualization of a bone graft area of the cervical spine after attachment of the present cervical plate to the vertebrae. The window is preferably, but not necessarily, sized for maximum exposure of the graft area and/or the vertebral body without compromising plate strength, particularly with respect to federal standards for such devices. The window is centrally positioned on the plate and is sized to provide alignment of the plate onto the vertebrae at the base of the vertebra fastener or screw holes of the plate. In a dynamic form of this cervical bone plate, the graft window expands and contracts with respective expansion and contraction of the dynamic plate after attachment to the vertebrae (i.e. “dynamizes”). In another form, a three-component dynamic bone plate is configured such that a middle component accepts an identical end component at both ends of the middle component. The end component is a 180° interchangeable part.Type: GrantFiled: December 21, 2004Date of Patent: May 22, 2012Assignee: Life Spine, Inc.Inventors: Michael S. Butler, Jeffrey C. Wang
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Patent number: 8105366Abstract: Laminoplasty plates are engageable to at least one portion of a divided lamina to maintain a desired spacing relative to the spinal canal. The laminoplasty plates include a spacer portion having a first end and a second end that spans a gap formed by at least one of a divided lamina portion. The laminoplasty plates can include a lamina engagement portion at one end for engagement with the divided lamina portion.Type: GrantFiled: May 28, 2003Date of Patent: January 31, 2012Assignee: Warsaw Orthopedic, Inc.Inventors: William B. Null, Robert W. Weakley, Gregory C. Marik, John G. Heller, Jeffrey C. Wang
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Patent number: 8043212Abstract: A method for providing treatment at or near a cervical region of the spine of a patient is provided. An incision is formed in the skin of a patient above the cervical region. An elongate body is inserted into the patient through the incision, the elongate body having a distal portion, a proximal portion, an outer surface, and an inner surface, the inner surface defining a passage extending through the elongate body. The elongate body is advanced until a distal end thereof resides at or near the cervical region of the spine. The size of the passage in the distal portion is increased relative to the size of the proximal portion.Type: GrantFiled: September 27, 2005Date of Patent: October 25, 2011Assignee: Zimmer Spine, Inc.Inventors: Hyun W. Bae, Robert F. Heary, Alan S. Hilibrand, Ashwini D. Sharan, Jeffrey C. Wang, Gene P. DiPoto, John D. Unger
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Patent number: 7959677Abstract: Insertion methods for placing dynamic interbody devices between a first vertebra and a second vertebra using a posterior approach are provided. In an embodiment, the insertion method may be based on the first vertebra. A bridge assembly may be attached to tap shafts positioned in the first vertebra. The bridge assembly may establish an insertion angle of implants into a disc space between the vertebrae. In an embodiment, the insertion method may be based on the position of expandable trials positioned between the vertebrae. The trials may be positioned and a bridge assembly may be coupled to the expandable trials and taps positioned in the first vertebra. One or more posterior stabilization systems may be coupled to the vertebrae after insertion of the dynamic interbody devices between the vertebrae.Type: GrantFiled: January 19, 2007Date of Patent: June 14, 2011Assignee: Flexuspine, Inc.Inventors: Michael E. Landry, Erik J. Wagner, Michael S. Schular, Jeffrey C. Wang