Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.

Abstract: Pressure regulators with adjustable boost bodies are described herein. An example pressure regulator includes a valve body; a seat in the fluid passageway; an actuator casing coupled to the valve body; and a plug assembly including: a stem; a plug coupled to the stem; a stem guide disposed in the channel of the actuator casing; a boost body on the second side of the stem guide; and a tube extending through the boost body, the tube and the boost body forming a unitary structure to prevent movement of the tube relative to the boost body, the tube having a first end and a second end, the second end disposed in a downstream location relative to the seat, wherein the boost body is rotatable with respect to the stem guide to position the tube in at least one other orientation relative to the actuator casing.

Abstract: A 3D printer can print a structure by depositing material into a weld pool that is moving relative to a workpiece. A multi-wire process may be utilized to increase the deposition rate of the 3D printer. An electrode wire can supply energy to the weld pool while being fed at a first feed rate into the weld pool. A second wire can be fed into the weld pool at a second feed rate to deposit additional material and thereby speed up the overall material deposition rate. All of the energy in the weld pool may be supplied by the electrode wire. Different materials may benefit from different orientations of the electrode wire and the second wire.

Abstract: An analytical toilet, comprising: a bowl adapted to receive excreta; one or more conduits for transporting a sample from the bowl; one or more fluid sources in fluid connection with the one or more conduits; and one or more microfluidic chips, comprising: at least one microfluidic fluid inlet channel; and a sensor configured to detect at least one property of an excreta sample is disclosed.

Abstract: The present disclosure relates to methods for obtaining health and wellness information about individuals and systems for implementing the method. In one embodiment, a method for obtaining health and wellness information about an individual comprising providing an analytical toilet comprising a bowl adapted to receive excreta from the individual and a sensor for measuring at least one characteristic of the individual or the excreta; a controller receiving data from the sensor and using that data to determine what additional information is needed to evaluate that data; the controller sending a prompt to the individual to solicit the additional information from the individual; the processor receiving the information from the device; and processing the data from the sensor and from the device to determine the health and wellness information is disclosed.

Abstract: A machinable 3-D printing build plate that can be assembled from a number of different components into the base for a metallic 3-D printing volume and other 3-D printed parts. The build plate can be assembled into a final structure then machined to the required planar tolerance such that the build quality of the part is maintained throughout the build. Additionally, because the baseline printer support structure and support device are comprised of multiple elements, if one or more goes out of tolerance or requires adjustment to accommodate a new print, it may be easily removed, replaced then machined back to the required tolerances.

Abstract: Systems and methods for wire arc additive manufacturing systems that print in horizontal orientations are described. Horizontal WAAM 3D print systems comprise metal 3D print systems in a horizontal orientation with one or more robots operating concurrently on a work piece using one or more wire feeds and a rotating, horizontal build plate.

Abstract: An analytical toilet, comprising: a bowl for receiving excreta supported by a base; a pressure sensor mounting fixture, comprising: a chamber with an outlet, wherein the chamber is in fluid communication with the contents of the bowl through the outlet, a pressure sensor cavity above the chamber having an inlet in fluid communication with the chamber such that an air bubble is maintained in the pressure sensor cavity, and a pressure sensor adapted to measure the pressure in the pressure sensor cavity is disclosed. The disclosed toilet is able to accurately measure changes to the contents of the bowl by measuring changes to the pressure in the bowl using a pressure sensor that is kept separated from the toilet contents.

Abstract: An analytical toilet comprising a bowl for receiving excreta from a user; a flush mechanism for cleaning the bowl after use; at least one analytical test device wherein a sample of excreta is analyzed; a manifold comprising conduits and valves for distributing one or more fluids to and from the at least one receptacle; and a digital control device controlling the valves to distribute the sample to the analytical test device for analysis; and distribute fluid to remove the sample from the analytical test device after analysis and to clean the analytical test device is disclosed.

Abstract: An analytical toilet comprising a bowl adapted to receive excreta; one or more conduits for transporting a sample from the bowl; one or more fluid sources in fluid connection with the one or more conduits; and one or more microfluidic chips, comprising at least one fluid inlet; at least one fluid outlet; and a sensor configured to detect at least one property of an excreta sample is disclosed.

Abstract: An analytical toilet comprising: a bowl for collecting feces from a user; a comminutor that comminutes at least a portion of the feces; a processing fluid driver that causes a processing fluid to mix with and transport at least a portion of the comminuted feces to an analytical station in the toilet; a separator that separates a sample of the at least a portion of the comminuted feces to be analyzed; and a wash fluid driver that causes a wash fluid to wash the feces out of the bowl.

Abstract: A 3D printer can print a structure by depositing material into a weld pool that is moving relative to a workpiece. An electrode wire can supply energy to the weld pool while being fed at a first feed rate into the weld pool. A second wire can be fed into the weld pool at a second feed rate to deposit additional material and thereby speed up the overall material deposition rate. All of the energy in the weld pool may be supplied by the electrode wire. The printer can dynamically control the first feed rate and the second feed rate during printing. A mathematical model can be used to determine the second feed rate as a function of the first feed rate, the energy put into the weld pool, and the print head travel speed. The second feed rate may optimize the material deposition rate according to the model.

Abstract: An analytical toilet comprising a bowl for receiving excreta from a user; a base supporting the bowl; a supply of flush water; and a plurality of receptacles, each providing mechanical attachment, a power supply, and a data connection to an analytical device, which analytical device is adapted to provide data useful to the user is disclosed.

Abstract: A toilet is disclosed. The toilet has a bowl adapted to receive excreta, a shelf for receiving feces in the bowl, and one or more sensor for detecting a property of the feces. The property may be related to a user's heath and wellness and may be presented to a person for their review and assessment.

Abstract: An analytical toilet is disclosed with a bowl adapted to receive excreta, a conduit for transporting a liquid excreta sample from the bowl, and a liquid reagent source. The analytical toilet also includes a microfluidic chip that has a sensor configured to detect at least one property of the excreta sample. The microfluidic chip also has an excreta sample path in fluid communication with the conduit and the sensor and a reagent path in fluid communication with the liquid reagent source and the sensor. The length of and number of channels in the sample path and the reagent path are selected so as to control the respective fluid resistance of the excreta sample and the reagent to thereby optimize the mixing and flow rates of the excreta sample and reagent into the sensor. There is also disclosed analytical toilet with a microfluidic chip having reagent path that includes a first and a second channel. The second channel is longer than the first channel.

Abstract: An analytical toilet is disclosed, having a bowl for receiving excreta supported by a base. The toilet also includes a pressure sensor mounting fixture, which has: a chamber with an outlet. The chamber is in fluid communication with the contents of the bowl through the outlet. The pressure sensor mounting fixture also has a pressure sensor cavity above the chamber having an inlet in fluid communication with the chamber such that an air bubble is maintained in the pressure sensor cavity. A pressure sensor is included that is adapted to measure the pressure in the pressure sensor cavity. Also, a system is disclosed for measuring changes in the volume in a toilet bowl. The system includes a pressure sensor mounting fixture, having a chamber with an outlet. The chamber is in fluid communication with the contents of the bowl through the outlet.

Abstract: Disclosed are systems and methods of generating electrical power utilizing a mining bank of individual blockchain miners. The blockchain miners operate as a revenue generating heat source that provides thermal energy into a power plant's Rankine or Brayton cycle turbines.

Abstract: The present invention relates to the discovery of small molecule compounds that act as GLP-1R agonists and/or as positive allosteric modulators (PAMs) of GLP-1R. Such compounds are useful to treat, ameliorate, and/or prevent insulin resistance and/or diabetes in a mammal.

Abstract: High permeability curly fibers with enhanced fiber strength are produced by mercerizing cellulosic fibers. The fibers have relatively high values for curl, kink level, wet tensile strength, and bulk density when compared with current fibers. The disclosed fibers can be used in a wide range of applications including paper products such as filters.

Abstract: Devices and methods for internet of things (IOT) discovery/auto discovery are described. A discovery packet is received from a device. The discovery packet includes a first stream identifier and a request to establish a second stream. A stream acceptance packet is sent to the device. The stream acceptance packet includes the first stream identifier and an input for generating a second stream identifier. A first association is added to the registration based on the request to establish the second stream. The first association is between the second stream identifier and a determined destination. A first data packet is received from the device, where the first data packet includes/utilizes the second stream identifier. The first data packet is sent to the destination based on the first association in the registration.