Abstract: Devices, systems, and methods for distinguishing tissue types are described herein. Such devices and systems may use dual polarization, conformal filters to acquire image data from target tissues and a processor to create an image in which the contrast between tissues has been enhanced.

Abstract: A method of providing messaging comprises the steps of providing display of messages exchanged between a plurality of participants; receiving designation of one of said messages as an anchor message; permitting a response received to said anchor message from one of said plurality of participants to be provided to all others of said plurality of participants; providing display of said response; and receiving at least a further response to said anchor message from at least one of said plurality of participants, wherein at least an excluded one of said plurality of participants is prevented from receiving at least said further response.

Abstract: A virtual online meeting room is provided. An external message is received by an originator user from an outside source. The external message is displayed to an originator user and is prevented from being displayed to remainder users. The originator user is permitted to designate at least a portion of the external message as shared. At least one of the remainder users is permitted to have at least the portion of the external message displayed to them responsive to the at least the portion of the external message being designated as shared.

Abstract: Devices, systems, and methods for distinguishing tissue types are described herein. Such devices and systems may use dual polarization, conformal filters to acquire image data from target tissues and a processor to create an image in which the contrast between tissues has been enhanced.

Abstract: The inventive ablation element comprises an elongated cannula having a proximal end and a distal end. The cannula defines an internal lumen within the cannula and a cannula axis. A plurality of conductors contained within the lumen, each of the conductors has a proximal end proximate the proximal end of the cannula, and a distal end proximate the distal end of the cannula. A plurality of ablation stylets each has a proximal end and a distal end, and each coupled at the respective proximal end of the stylet to the distal end of a respective conductor, the stylets comprise a deflectable material, the conductors together with their respective stylets being mounted for axial movement. A trocar point defined proximate the distal end of the cannula.

Abstract: A method of providing messaging comprises the steps of providing display of messages exchanged between a plurality of participants; receiving designation of one of said messages as an anchor message; permitting a response received to said anchor message from one of said plurality of participants to be provided to all others of said plurality of participants; providing display of said response; and receiving at least a further response to said anchor message from at least one of said plurality of participants, wherein at least an excluded one of said plurality of participants is prevented from receiving at least said further response.

Abstract: Implementations disclosed herein provide for integrating actionable objects into an on-line chat communications platform. A method is provided in which state information of a chat message session between participants of a group is determined. A selection of one of a plurality of actionable objects is received based on the state information. Each actionable object comprises a type indicator to characterize a user perceivable action associated with the actionable object. Responsive to the selection, at least one participant is associated with the actionable object. The actionable object is provided to the chat message session to be selectably executed by a client device of the participant. The providing comprises updating the state information of the chat message session in accordance with the at least one actionable object.

Abstract: The inventive ablation element comprises an elongated cannula having a proximal end and a distal end. The cannula defines an internal lumen within the cannula and a cannula axis. A plurality of conductors contained within the lumen, each of the conductors has a proximal end proximate the proximal end of the cannula, and a distal end proximate the distal end of the cannula. A plurality of ablation stylets each has a proximal end and a distal end, and each coupled at the respective proximal end of the stylet to the distal end of a respective conductor, the stylets comprise a deflectable material, the conductors together with their respective stylets being mounted for axial movement. A trocar point defined proximate the distal end of the cannula.

Abstract: Implementations disclosed herein provide for integrating actionable objects into an on-line chat communications platform. A method is provided in which state information of a chat message session between participants of a group is determined. A selection of one of a plurality of actionable objects is received based on the state information. Each actionable object comprises a type indicator to characterize a user perceivable action associated with the actionable object. Responsive to the selection, at least one participant is associated with the actionable object. The actionable object is provided to the chat message session to be selectably executed by a client device of the participant. The providing comprises updating the state information of the chat message session in accordance with the at least one actionable object.

Abstract: Vaccines are provided that elicit neutralizing antibodies to Epstein-Barr virus (EBV). Some vaccines comprise nanoparticles that display envelope proteins from EBV on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to at least a portion of an EBV envelope protein. The fusion proteins self-assemble to form the envelope protein-displaying nanoparticles. Such vaccines can be used to vaccinate an individual against infection by different types of Epstein-Barr viruses as well as Epstein-Barr viruses that are antigenically divergent from the virus from which the EBV envelope protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins.

Abstract: A method and system for executing database queries in parallel using a shared metadata store. The metadata store may reside on a master node, and the master node may distribute this metadata with query plans to worker nodes. The worker nodes may request additional metadata from the master node when necessary.

Abstract: A method for analyzing organ samples using hyperspectral imaging comprising illuminating an organ sample to generate interacted photons, collecting the interacted photons and passing the interacted photons through a tunable filter. The filtered interacted photons are detected to generate a hyperspectral image. A brightfield image is generated and associated with the hyperspectral image. Spectra from locations of interest are extracted and analyzed to assess a characteristic of the organ sample. A system may comprise an illumination source to illuminate an organ sample and generate interacted photons, a collection optics for collecting the interacted photons and a tunable filter to filter the interacted photons. A detector is configured to detect the filtered photons and generate at least one hyperspectral image. The detector may also be configured to generate at least one brightfield image representative of the organ sample.

Abstract: Database system comprising nodes configured in a tree structure is disclosed. The system includes a shared metadata store on the root node. Child nodes may request metadata from their ancestors. Parents will forward the request upward until the metadata is found or the root node is reached.

Abstract: The present invention provides an imaging service method and system by which medical images stored in the DICOM standard in a central medical imaging repository may be seamlessly and securely accessed, and operated on, by electronic data capture (EDC) or eClinical data systems. The interoperability between web-based Medical Imaging Repositories and eClinical systems provided by the present invention may increase data quality and visibility to clinical workflow involving medical imaging, decrease delays in accessing images and their clinical measurements, and improve the functionality of DICOM-based MIR systems by providing measurement-based versions.

Abstract: Devices, systems, and methods for distinguishing tissue types are described herein. Such devices and systems may use dual polarization, conformal filters to acquire image data from target tissues and a processor to create an image in which the contrast between tissues has been enhanced.

Abstract: A method for analyzing organ samples using hyperspectral imaging comprising illuminating an organ sample to generate interacted photons, collecting the interacted photons and passing the interacted photons through a tunable filter. The filtered interacted photons are detected to generate a hyperspectral image. A brightfield image is generated and associated with the hyperspectral image. Spectra from locations of interest are extracted and analyzed to assess a characteristic of the organ sample. A system may comprise an illumination source to illuminate an organ sample and generate interacted photons, a collection optics for collecting the interacted photons and a tunable filter to filter the interacted photons. A detector is configured to detect the filtered photons and generate at least one hyperspectral image. The detector may also be configured to generate at least one brightfield image representative of the organ sample.

Abstract: The present disclosure provides for a system and method for assessing chronic exposure of a biological sample, such as a bodily fluid, to an analyte of interest. A biological sample may be illuminated to thereby generate a one or more pluralities of interacted photons. These interacted photons may be detected to thereby generate one or more spectroscopic data sets representative of a biological sample. Spectroscopic data sets generated may be compared to at least one reference data set. Each reference data set may be associated with a known exposure to a known analyte. The present disclosure contemplates that the system and method disclosed herein may be used to analyze exposure of biological samples to at least one analyte over time. Data sets may be obtained at various time intervals to assess changes in a molecular composition as a result of chronic exposure to an analyte.

Abstract: A system and method for detecting environmental conditions using SWIR hyperspectral imaging. A method may comprise collecting a plurality of interacted photons from at least one location and passing the interacted photons through a tunable filter, filtering the interacted photons into a plurality of wavelength bands. These filtered photons may be detected and analyzed to determine the presence or absence of an environmental condition. A system may comprise at least one collection lens configured to collect at least one plurality of interacted photons from at least one location and a tunable filter for filtering the interacted photons into a plurality of wavelength bands. The system may further comprise a detector configured to detect the filtered photons and generate at least one hyperspectral image representative of the location. The system may further comprise a processor for analyzing the hyperspectral data set and determining the presence or absence of an environmental condition.

Abstract: A method for generating an image of a sample that is informative of the disease state of a cell in the sample. A sample including the cell is irradiated with monochromatic light. The Raman scattered light is assessed. A digital brightfield image of the Raman scattered light is generated and combined with the Raman scattered light emitted by the cell whereby the Raman scattered light is informative of the disease state of the cell in the sample. The method can also be used to determine the metabolic activity of the cell, the inflammatory status of the cell and/or the infected status of the cell in the sample.

Abstract: The present disclosure provides for a system and method for assessing chronic exposure of a biological sample, such as a bodily fluid, to an analyte of interest. A biological sample may be illuminated to thereby generate a one or more pluralities of interacted photons. These interacted photons may be detected to thereby generate one or more spectroscopic data sets representative of a biological sample. Spectroscopic data sets generated may be compared to at least one reference data set. Each reference data set may be associated with a known exposure to a known analyte. The present disclosure contemplates that the system and method disclosed herein may be used to analyze exposure of biological samples to at least one analyte over time. Data sets may be obtained at various time intervals to assess changes in a molecular composition as a result of chronic exposure to an analyte.