Patents by Inventor Jeffrey Curtis Kern

Jeffrey Curtis Kern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ION CHANNEL MODULATORS
    Publication number: 20100267697
    Abstract: The present teachings provide compounds of Formula (I) and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R1, R2, R3, p, and X are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.
    Type: Application
    Filed: December 11, 2007
    Publication date: October 21, 2010
    Applicant: Wyeth
    Inventors: Vincent P. Galullo, Robert Zelle, Danielle Soenen, Christopher Todd Baker, Paul Will, Hormoz Mazdiyasni, Jinsong Guo, Andrew Fensome, Jeffrey Curtis Kern, William Jay Moore, Edward George Melenski, Justin Kaplan
  • 5-ARYL INDAN-1-ONE AND ANALOGS USEFUL AS PROGESTERONE RECEPTOR MODULATORS
    Publication number: 20090325916
    Abstract: Compounds of formula I or II and pharmaceutical compositions and kits containing these compounds are provided. Also provided are methods of inducing contraception, providing hormone replacement therapy, treating cycle-related symptoms, or treating or preventing benign or malignant neoplastic disease using the compounds of formula I, formula II, or formula III.
    Type: Application
    Filed: September 2, 2009
    Publication date: December 31, 2009
    Applicant: Wyeth
    Inventors: Puwen Zhang, Jeffrey Curtis Kern, Eugene Anthony Terefenko, Eugene John Trybulski
  • 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators
    Patent number: 7598237
    Abstract: This invention provides progesterone receptor modulators having the structure: wherein R1 to R7, X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 28, 2007
    Date of Patent: October 6, 2009
    Assignee: Wyeth
    Inventors: Puwen Zhang, Jay Edward Wrobel, Eugene Anthony Terefenko, Jeffrey Curtis Kern
  • 5-aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators
    Patent number: 7414142
    Abstract: Compounds of formula I, wherein R1-R9 and n are defined herein, and pharmaceutical compositions and kits containing these compounds are provided. Also provided are methods of inducing contraception, providing hormone replacement therapy, treating cycle-related symptoms, or treating or preventing benign or malignant neoplastic disease using the compounds of formula I or formula II, wherein R3-R5, R10, and R11 are defined herein.
    Type: Grant
    Filed: September 18, 2006
    Date of Patent: August 19, 2008
    Assignee: Wyeth
    Inventors: Puwen Zhang, Jeffrey Curtis Kern, Eugene Anthony Terefenko, Eugene John Trybulski
  • 7-Aryl 1,5-Dihydro-4,1-Benzoxazepin-2(3H)-One Derivatives And Their Use As Progesterone Receptor Modulators
    Publication number: 20080139530
    Abstract: This invention provides progesterone receptor modulators having the structure: wherein R1 to R7, X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 28, 2007
    Publication date: June 12, 2008
    Applicant: Wyeth
    Inventors: Puwen Zhang, Jay Edward Wrober, Eugene Anthony Terefenko, Jeffrey Curtis Kern
  • 7-Aryl 1,5-Dihydro-4,1-Benzoxazepin-2(3H)-One Derivatives and Their Use As Progesterone Receptor Modulators
    Publication number: 20080113964
    Abstract: This invention provides progesterone receptor modulators having the structure: wherein R1 to R7, X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 28, 2007
    Publication date: May 15, 2008
    Applicant: Wyeth
    Inventors: Puwen Zhang, Jay Edward Wrobel, Eugene Anthony Terefenko, Jeffrey Curtis Kern
  • 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3)-one derivatives and their use as progesterone receptor modulators
    Patent number: 7323455
    Abstract: This invention provides progesterone receptor modulators having the structure: wherein R1 to R7, X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 22, 2005
    Date of Patent: January 29, 2008
    Assignee: Wyeth
    Inventors: Puwen Zhang, Jay Edward Wrobel, Eugene Anthony Terefenko, Jeffrey Curtis Kern
  • 5-Aryl-indan-1-one and analogs useful as progesterone receptor modulators
    Patent number: 7319152
    Abstract: Compounds of formula I or II are provided, wherein R1-R8 are defined herein, and pharmaceutical compositions and kits containing these compounds.
    Type: Grant
    Filed: September 18, 2006
    Date of Patent: January 15, 2008
    Assignee: Wyeth
    Inventors: Puwen Zhang, Jeffrey Curtis Kern, Eugene Anthony Terefenko, Eugene John Trybulski
  • Cyclothiocarbamate derivatives as progesterone receptor modulators and methods of treating skin disorders
    Patent number: 7268149
    Abstract: The present invention provides methods of treating skin disorders includes delivering to a mammal a composition containing a compound of formula I, or tautomers thereof, in a regimen, wherein formula I is: and wherein R1-R5 and Q1 are defined as described herein. Specifically, methods for treating acne, hirsutism, and conditioning the skin are described. Also provided are novel PR modulators of formula II.
    Type: Grant
    Filed: June 23, 2003
    Date of Patent: September 11, 2007
    Assignee: Wyeth
    Inventors: Andrew Fensome, Diane Deborah Harrison, Richard Craig Winneker, Puwen Zhang, Jeffrey Curtis Kern, Eugene Anthony Terefenko
  • Methods of treating hormone-related conditions using cyclothiocarbamate derivatives
    Patent number: 7192956
    Abstract: The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I or formula II, or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula I is: and wherein R1–R5 and Q1 are defined as described herein. Methods of providing hormone replacement therapy and for treating carcinomas, dysfunctional bleeding, uterine leiomyomata, endometriosis, and polycystic ovary syndrome is provided which includes delivering a compound of formula I and a selective estrogen receptor modulator are also described.
    Type: Grant
    Filed: June 23, 2003
    Date of Patent: March 20, 2007
    Assignee: Wyeth
    Inventors: Andrew Fensome, Gary S. Grubb, Diane Deborah Harrison, Richard Craig Winneker, Puwen Zhang, Jeffrey Curtis Kern, Eugene Anthony Terefenko
  • Cyclothiocarbamate derivatives as progesterone receptor modulators and methods of treating skin disorders
    Publication number: 20040014798
    Abstract: The present invention provides methods of treating skin disorders includes delivering to a mammal a composition containing a compound of formula I, or tautomers thereof, in a regimen, wherein formula I is: 1
    Type: Application
    Filed: June 23, 2003
    Publication date: January 22, 2004
    Applicant: Wyeth
    Inventors: Andrew Fensome, Diane Deborah Harrison, Richard Craig Winneker, Puwen Zhang, Jeffrey Curtis Kern, Eugene Anthony Terefenko
  • Methods of treating hormone-related conditions using cyclothiocarbamate derivatives
    Publication number: 20040006060
    Abstract: The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I or formula II, or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula I is: 1
    Type: Application
    Filed: June 23, 2003
    Publication date: January 8, 2004
    Applicant: Wyeth
    Inventors: Andrew Fensome, Gary S. Grubb, Diane Deborah Harrison, Richard Craig Winneker, Puwen Zhang, Jeffrey Curtis Kern, Eugene Anthony Terefenko