Abstract: An end-effector is disclosed including an ultrasonic blade configured to acoustically couple to an ultrasonic transducer and electrically couple to a pole of an electrical generator and a clamp arm including a clamp jaw and a cantilever electrode fixed to the clamp jaw. The cantilever electrode is configured to electrically couple to an opposite pole of the electrical generator. The clamp arm may include an I-beam shaped clamp arm pad and the cantilever electrode is disposed between the I-beam. The clamp jaw, the cantilever electrode, and the clamp arm pad may define recesses along a length coinciding with the ultrasonic blade. The clamp arm pad may be fixed to the clamp jaw and disposed between the clamp jaw and the cantilever electrode and may extend beyond the surface of the cantilever electrode. The clamp arm may include a stationary gap setting pad and movable floating gap setting pads.

Abstract: An end-effector is disclosed. The end-effector includes a clamp arm and an ultrasonic blade configured to acoustically couple to an ultrasonic transducer and to electrically couple to a pole of an electrical generator. The clamp arm includes a clamp jaw, a plurality of variable longitudinal support elements, and a cantilever electrode configured to electrically couple to an opposite pole of the electrical generator, the cantilever electrode fixed to the clamp jaw at a proximal end and free to deflect at a distal end. The cantilever electrode is supported by the variable longitudinal support elements. The variable longitudinal support elements apply a variable force on the cantilever electrode from the proximal end to the distal end.

Abstract: Techniques are disclosed relating to thread preemption in the context of memory-backed registers. In some embodiments, a memory hierarchy includes one or more cache levels and one or more memory circuits. Execution circuitry may operate on operands in architectural registers to execute instructions of threads, where data for the architectural registers is stored and backed by the memory hierarchy. Control circuitry may, in response to a context switch indication for a given thread: flush and invalidate a set of architectural register data from a first cache level and store memory page information (e.g., a page catalog base address) associated with the set of architectural register data.

Abstract: This invention relates to a method of assaying pyrrole-containing biological compounds and chemical compositions that can be used in the method. The method involves contacting a biological compound with one of: a) a bound or bindable derivatizing agent which forms a reaction product with the biological compound, followed by exposure to a detectable molecule which forms a complex with the reaction product; or b) a derivatizing agent which forms a reaction product with the biological compound, followed by exposure to a bound binding agent specific to the biological compound in the reaction product; or c) a binding agent specific to the biological compound, followed by exposure to a derivatizing agent which forms a reaction product with the biological compound, and determining the amount of bound biological compound. There is also provided a method of preparing an antigen.

Abstract: This invention relates to a method of assaying pyrrole-containing biological compounds and chemical compositions that can be used in the method. The method involves contacting a biological compound with one of: a) a bound or bindable derivatizing agent which forms a reaction product with the biological compound, followed by exposure to a detectable molecule which forms a complex with the reaction product; or b) a derivatizing agent which forms a reaction product with the biological compound, followed by exposure to a bound binding agent specific to the biological compound in the reaction product; or c) a binding agent specific to the biological compound, followed by exposure to a derivatizing agent which forms a reaction product with the biological compound, and determining the amount of bound biological compound. There is also provided a method of preparing an antigen.

Abstract: This invention relates to a method of assaying pyrrole-containing biological compounds and chemical compositions that can be used in the method.

Abstract: Disclosed is a method for measuring a level of pyridinoline and/or deoxypyridinoline in a sample. In the method, a non-hydrolyzed sample containing one or more peptide-bound collagen pyridinium crosslinks selected from the group consisting of pyridinoline, deoxypyridinoline, or both, is contacted with a protease reagent under conditions effective for the protease reagent to cleave the crosslinks from attached collagen amino acids and peptides, so that peptide-bound forms are converted to native, peptide-free pyridinoline and deoxypyridinoline. After proteolysis, the level(s) of native, peptide-free pyridinoline and/or deoxypyridinoline are measured. Preferably, proteolysis is effective to ensure that at least 80% of total pyridinium crosslinks are present as the native, peptide-free forms. The method is particularly useful in screening or monitoring collagen degradation activity. Kits and reagents for use in the method are also disclosed.

Abstract: This invention relates to a method of assaying pyrrole-containing biological compounds and chemical compositions that can be used in the method.

Abstract: This invention relates to a method of assaying pyrrole-containing biological compounds and chemical compositions that can be used in the method. The method involves contacting a biological compound with one of: a) a bound or bindable derivatizing agent which forms a reaction product with the biological compound, followed by exposure to a detectable molecule which forms a complex with the reaction product; or b) a derivatizing agent which forms a reaction product with the biological compound, followed by exposure to a bound binding agent specific to the biological compound in the reaction product; or c) a binding agent specific to the biological compound, followed by exposure to a derivatizing agent which forms a reaction product with the biological compound, and determining the amount of bound biological compound. There is also provided a method of preparing an antigen.

Abstract: This invention relates to a method of assaying pyrrole-containing biological compounds and chemical compositions that can be used in the method.