Patents by Inventor Jeffrey D. BUTLER

Jeffrey D. BUTLER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for enriching alpha-tocotrienol from mixed tocol compositions
    Patent number: 11560364
    Abstract: Provided herein are methods for making an alpha-tocotrienol enriched tocol mixture, such as from a plant or plant-derived material. Also provided herein are simulated moving bed purification methods for tocotrienol compounds such as alpha tocotrienol.
    Type: Grant
    Filed: October 26, 2021
    Date of Patent: January 24, 2023
    Assignee: PTC THERAPEUTICS, INC.
    Inventors: Peter Giannousis, Paul Mollard, Noah M. Benjamin, Jeffrey D. Butler, Olivier Dapremont, James B. Falabella
  • METHODS FOR ENRICHING ALPHA-TOCOTRIENOL FROM MIXED TOCOL COMPOSITIONS
    Publication number: 20220048880
    Abstract: Provided herein are methods for making an alpha-tocotrienol enriched tocol mixture, such as from a plant or plant-derived material. Also provided herein are simulated moving bed purification methods for tocotrienol compounds such as alpha tocotrienol.
    Type: Application
    Filed: October 26, 2021
    Publication date: February 17, 2022
    Inventors: Peter GIANNOUSIS, Paul MOLLARD, Noah M. BENJAMIN, Jeffrey D. BUTLER, Olivier DAPREMONT, James B. FALABELLA
  • Methods for enriching alpha-tocotrienol from mixed tocol compositions
    Patent number: 11186559
    Abstract: Provided herein are methods for making an alpha-tocotrienol enriched tocol mixture, such as from a plant or plant-derived material. Also provided herein are simulated moving bed purification methods for tocotrienol compounds such as alpha tocotrienol.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: November 30, 2021
    Assignee: PTC Therapeutics, Inc.
    Inventors: Peter Giannousis, Paul Mollard, Noah M. Benjamin, Jeffrey D. Butler, Olivier Dapremont, James B. Falabella
  • METHODS FOR ENRICHING ALPHA-TOCOTRIENOL FROM MIXED TOCOL COMPOSITIONS
    Publication number: 20200377468
    Abstract: Provided herein are methods for making an alpha-tocotrienol enriched tocol mixture, such as from a plant or plant-derived material. Also provided herein are simulated moving bed purification methods for tocotrienol compounds such as alpha tocotrienol.
    Type: Application
    Filed: August 17, 2020
    Publication date: December 3, 2020
    Inventors: Peter GIANNOUSIS, Paul MOLLARD, Noah M. BENJAMIN, Jeffrey D. BUTLER, Olivier DAPREMONT, James B. FALABELLA
  • Methods for enriching alpha-tocotrienol from mixed tocol compositions
    Patent number: 10745371
    Abstract: Provided herein are methods for making an alpha-tocotrienol enriched tocol mixture, such as from a plant or plant-derived material. Also provided herein are simulated moving bed purification methods for tocotrienol compounds such as alpha tocotrienol.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: August 18, 2020
    Assignee: PTC Therapeutics, Inc.
    Inventors: Peter Giannousis, Paul Mollard, Noah M. Benjamin, Jeffrey D. Butler, Olivier Dapremont, James B. Falabella
  • IMPROVED METHODS FOR ENRICHING ALPHA-TOCOTRIENOL FROM MIXED TOCOL COMPOSITIONS
    Publication number: 20180362492
    Abstract: Provided herein are methods for making an alpha-tocotrienol enriched tocol mixture, such as from a plant or plant-derived material. Also provided herein are simulated moving bed purification methods for tocotrienol compounds such as alpha tocotrienol.
    Type: Application
    Filed: December 16, 2016
    Publication date: December 20, 2018
    Inventors: Peter GIANNOUSIS, Paul MOLLARD, Noah M. BENJAMIN, Jeffrey D. BUTLER, Olivier DAPREMONT, James B. FALABELLA
  • Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
    Patent number: 9090539
    Abstract: Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds from an isomerically pure starting material are described. In particular, methods of preparing a 3-(1-(dimethylamino)-2-methylpentane-3-yl)phenol as a substantially optically pure (R,R) stereoisomer are described. Using a method of the present invention, only the (R,R) and (S,S) stereoisomers of the target compound are produced, increasing the yield and stereoselectivity of the desired (R,R) stereoisomer.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: July 28, 2015
    Assignee: AMPAC Fine Chemicals LLC
    Inventors: Brian Morgan, Olivier Dapremont, Patrick Berget, Ali Suleman, William Dubay, Jeffrey D. Butler
  • Compounds and Methods for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds
    Publication number: 20140350283
    Abstract: Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds from an isomerically pure starting material are described. In particular, methods of preparing a 3-(1-(dimethylamino)-2-methylpentane-3-yl)phenol as a substantially optically pure (R,R) stereoisomer are described. Using a method of the present invention, only the (R,R) and (S,S) stereoisomers of the target compound are produced, increasing the yield and stereoselectivity of the desired (R,R) stereoisomer.
    Type: Application
    Filed: May 24, 2013
    Publication date: November 27, 2014
    Inventors: Brian MORGAN, Olivier DAPREMONT, Patrick BERGET, Ali SULEMAN, William DUBAY, Jeffrey D. BUTLER
  • NOVEL STEREOISOMERIC MIXTURES, SYNTHESIS AND USES THEREOF
    Publication number: 20140051888
    Abstract: A novel stereochemical mixture of 1,6-diaryl-2,5-diaminohexanes, such as a mixture of stereoisomers of 1,6-diphenylhexane-2,5-diamine, is described. Also described are methods of preparing stereochemically pure 1,6-diaryl-2,5-diaminohexanes, and particularly stereochemically pure 1,6-diphenyl-2,5-diaminohexane. Also described is the use of both the mixture of stereoisomers and the individual stereoisomers.
    Type: Application
    Filed: July 31, 2013
    Publication date: February 20, 2014
    Applicant: AMPAC FINE CHEMICALS LLC
    Inventors: William DUBAY, Jeffrey D. BUTLER, Charles L. LIOTTA