Abstract: Provided herein are sample collection devices that include a first body structure portion that comprises a drying agent compartment configured to receive a drying agent and a second body structure portion operably connected, or connectable, to the first body structure portion. The second body structure portion includes a sample collection support compartment comprising one or more segments that communicate with the drying agent compartment at least when the first and second body structure portions are operably connected to one another in a closed position. The sample collection support compartment is configured to receive a sample collection support. Related kits, systems, computer readable media, and methods are also provided.