Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: Disclosed is a tangential on-board injector (TOBI) system that includes an annulus and a plurality of cooling airflow passages disposed about the annulus. Each cooling airflow passage of the plurality of cooling airflow passages includes an inlet opening having a polygonal inlet cross-section, the inlet opening having an inlet cross-sectional area. Each cooling airflow passage of the plurality of cooling airflow passages further includes an outlet opening having an outlet cross-section and an outlet cross-sectional area. The inlet cross-sectional area is greater in magnitude than the outlet cross-sectional area. Also disclosed are additive manufacturing methods for manufacturing the tangential on-board injector system and gas turbine engines that incorporate the tangential on-board injector system.

Abstract: Disclosed is a tangential on-board injector (TOBI) system that includes an annulus and a plurality of cooling airflow passages disposed about the annulus. Each cooling airflow passage of the plurality of cooling airflow passages includes an inlet opening having a polygonal inlet cross-section, the inlet opening having an inlet cross-sectional area. Each cooling airflow passage of the plurality of cooling airflow passages further includes an outlet opening having an outlet cross-section and an outlet cross-sectional area. The inlet cross-sectional area is greater in magnitude than the outlet cross-sectional area. Also disclosed are additive manufacturing methods for manufacturing the tangential on-board injector system and gas turbine engines that incorporate the tangential on-board injector system.

Abstract: Embodiments of an impeller shroud support for disposition around an impeller are provided, as are embodiments of gas turbine engine including impeller shroud supports. In one embodiment, the impeller shroud support includes a shroud body, a support arm joined to and extending around the shroud body, and a plurality of Mid-Impeller Bleed (MIB) flow passages. Each MIB flow passage includes, in turn, an inlet formed in the shroud body and configured to receive bleed air extracted from the impeller, a throat portion, an outlet formed in the support arm and through which the bleed air is discharged, and a curved intermediate section between the inlet and the outlet. During usage of the impeller shroud support, the curved intermediate section turns the bleed air flowing through the MIB passage in a radially outward direction prior to discharge from the outlet of the MIB flow passage.

Abstract: Embodiments of an impeller shroud support for disposition around an impeller are provided, as are embodiments of gas turbine engine including impeller shroud supports. In one embodiment, the impeller shroud support includes a shroud body, a support arm joined to and extending around the shroud body, and a plurality of Mid-Impeller Bleed (MIB) flow passages. Each MIB flow passage includes, in turn, an inlet formed in the shroud body and configured to receive bleed air extracted from the impeller, a throat portion, an outlet formed in the support arm and through which the bleed air is discharged, and a curved intermediate section between the inlet and the outlet. During usage of the impeller shroud support, the curved intermediate section turns the bleed air flowing through the MIB passage in a radially outward direction prior to discharge from the outlet of the MIB flow passage.