Patents by Inventor Jeffrey D. Hillman

Jeffrey D. Hillman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel antimicrobial polypeptides and methods of use
    Publication number: 20020177690
    Abstract: Antimicrobial compounds and compositions and uses thereof, including the treatment and prevention of bacterial infections are described. The compounds and compositions include lantibiotic polypeptides and the nucleic acid sequences encoding the polypeptides. The compounds and compositions are useful as antimicrobials in antibiotic pharmaceutical preparation and as an antimicrobial or antiseptic dentifrice.
    Type: Application
    Filed: March 13, 2002
    Publication date: November 28, 2002
    Applicant: University of Florida Research Foundation, Inc.
    Inventor: Jeffrey D. Hillman
  • Antimicrobial polypeptides and methods of use
    Patent number: 6475771
    Abstract: Antimicrobial compounds and compositions and uses thereof, including the treatment and prevention of bacterial infections are described. The compounds and compositions include lantibiotic polypeptides and the nucleic acid sequences encoding the polypeptides. The compounds and compositions are useful as antimicrobials in antibiotic pharmaceutical preparation and as an antimicrobial or antiseptic dentifrice.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: November 5, 2002
    Assignee: University of Florida Research Foundation
    Inventor: Jeffrey D. Hillman
  • Antimicrobial polypeptide and methods of use
    Patent number: 6391285
    Abstract: Antimicrobial compounds and compositions and uses thereof, including the treatment and prevention of bacterial infections are described. The compounds and compositions include lantibiotic polypeptides and the nucleic acid sequences encoding the polypeptides. The compounds and compositions are useful as antimicrobials in antibiotic pharmaceutical preparation and as an antimicrobial or antiseptic dentifrice.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: May 21, 2002
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: Jeffrey D. Hillman
  • Antimicrobial polypeptide, nucleic acid, and methods of use
    Patent number: 5932469
    Abstract: Antimicrobial compounds and compositions and uses thereof, including the treatment and prevention of bacterial infections are described. The compounds and compositions include lantibiotic polypeptides and the nucleic acid sequences encoding the polypeptides. The compounds and compositions are useful as antimicrobials in antibiotic pharmaceutical preparation and as an antimicrobial or antiseptic dentifrice.
    Type: Grant
    Filed: June 10, 1997
    Date of Patent: August 3, 1999
    Assignee: University of Florida
    Inventor: Jeffrey D. Hillman
  • Replacement therapy for dental caries
    Patent number: 5607672
    Abstract: Recombinant Streptococcus mutans strains characterized by a deficiency in lactic acid production and production of a recombinant alcohol dehydrogenase (ADH) are described, These recombinant S. mutans strains are suitable for use in a method for preventing treating dental caries.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 4, 1997
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: Jeffrey D. Hillman
  • Method of treating periodontosis
    Patent number: 4454109
    Abstract: A method of treating and preventing periodontosis caused by the presence of Actinobacillus actinomycetemcomitans, particularly juvenile periodontosis, which method comprises: contacting the oral cavity of the patient with an inhibitory amount of an effector strain of Streptococcus sanguis, Strep. uberis or Actinomyces bovis.
    Type: Grant
    Filed: March 11, 1982
    Date of Patent: June 12, 1984
    Assignee: Forsyth Dental Infirmary for Children
    Inventor: Jeffrey D. Hillman
  • Lactate dehydrogenase mutants of Streptococcus mutans
    Patent number: 4324860
    Abstract: Mutant strains have been isolated from Streptococcus mutans strain BHT-2(str) which are characterized by a single point mutation in the structural gene for the enzyme, L(+) lactate dehydrogenase, this enzyme being normally responsible for lactic acid production by this bacterium. Streptococcus mutans is believed to be a principal pathogen in dental caries, a disease characterized by the dissolution of the mineral portion of the tooth caused by acid resulting from the interaction of bacteria on the tooth surface with carbohydrates. The mutant strains of the invention will be found useful as prototype nonvirulent effector strains in controlling the incidence and severity of dental caries.
    Type: Grant
    Filed: October 6, 1978
    Date of Patent: April 13, 1982
    Assignee: Forsyth Dental Infirmary for Children
    Inventor: Jeffrey D. Hillman
  • Method of controlling dental caries with streptococcus mutans mutant strains
    Patent number: 4133875
    Abstract: Mutant strains have been isolated from Streptococcus mutans strain BHT-2(str) which are characterized by a single point mutation in the structural gene for the enzyme, L(+) lactate dehydrogenase, this enzyme being normally responsible for lactic acid production by this bacterium. Streptococcus mutans is believed to be a principal pathogen in dental caries, a disease characterized by the dissolution of the mineral portion of the tooth caused by acid resulting from the interaction of bacteria on the tooth surface with carbohydrates. The mutant strains of the invention will be found useful as prototype nonvirulent effector strains in controlling the incidence and severity of dental caries.
    Type: Grant
    Filed: February 23, 1978
    Date of Patent: January 9, 1979
    Assignee: Forsyth Dental Infirmary for Children
    Inventor: Jeffrey D. Hillman