Patents by Inventor Jeffrey D. Rothstein

Jeffrey D. Rothstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR INHIBITING CHMP7 EXPRESSION IN NEURONAL CELLS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
    Publication number: 20230407298
    Abstract: The present disclosure relates to methods of screening compounds which reduce or inhibit CHMP7 in neuronal cells or a population of cells and methods of inhibiting CHMP7 expression in a cell to treat one or more subjects suffering from one or more neurodegenerative diseases.
    Type: Application
    Filed: November 10, 2021
    Publication date: December 21, 2023
    Inventors: Jeffrey D. Rothstein, Alyssa Coyne
  • METHODS OF TREATING OR PREVENTING CONDITIONS OF DENDRITIC AND NEURAL SPINE DEFECTS
    Publication number: 20220041669
    Abstract: Described are methods of treating or preventing dendritic spine loss in a subject. The methods include a step of administering to a subject having or at risk of having dendritic spine loss a pharmaceutical composition. In addition, pharmaceutical compositions are described comprises an agent selected from the group comprising a salt, solvate, or stereoisomer of a norrin protein or functional part thereof; a vector expressing the norrin protein or functional part thereof; or a combination thereof, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: September 18, 2019
    Publication date: February 10, 2022
    Inventors: Sean James Miller, Jeffrey D. Rothstein
  • Methods for monitoring C9ORF72 expression
    Patent number: 10577604
    Abstract: Disclosed herein are methods for monitoring expression of C9ORF72 mRNA and protein in an animal with C9ORF72 specific inhibitors. Such C9ORF72 specific inhibitors include antisense compounds.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: March 3, 2020
    Assignees: Ionis Pharmaceuticals, Inc., The Johns Hopkins University
    Inventors: C. Frank Bennett, Susan M. Freier, Jeffrey D. Rothstein, Christopher Donnelly, Rita G. Sattler
  • METHODS FOR MONITORING C9ORF72 EXPRESSION
    Publication number: 20160024496
    Abstract: Disclosed herein are methods for monitoring expression of C9ORF72 mRNA and protein in an animal with C9ORF72 specific inhibitors. Such C9ORF72 specific inhibitors include antisense compounds.
    Type: Application
    Filed: October 15, 2013
    Publication date: January 28, 2016
    Applicants: The Johns Hopkins University, Isis Pharmaceuticals, Inc.
    Inventors: C. Frank Bennett, Susan M. Freier, Jeffrey D. Rothstein, Christopher Donnelly, Rita G. Sattler
  • Methods of identifying modulators of cellular glycosylation using GTRAP3-18
    Patent number: 8206931
    Abstract: The present invention provides methods and compositions for identifying compounds which modulate cellular glycosylation. The invention further provides methods for treating subjects suffering from or at risk of developing a glycosylation associated disorder.
    Type: Grant
    Filed: January 18, 2004
    Date of Patent: June 26, 2012
    Assignee: The Johns Hopkins University
    Inventors: Jeffrey D. Rothstein, Alicia Ruggiero
  • NEURODEGENERATIVE DISEASE DIAGNOSTIC COMPOSITIONS AND METHODS OF USE
    Publication number: 20120094295
    Abstract: The invention generally provides diagnostics that employ biomarkers altered in neurodegenerative disease, as well as methods for the use of such markers in monitoring disease progression and identifying agents useful for the treatment of a neurodegenerative disease.
    Type: Application
    Filed: November 20, 2009
    Publication date: April 19, 2012
    Applicant: The Johns Hopkins University
    Inventors: Rita G. Sattler, Jeffrey D. Rothstein, Richard Chipkin
  • TRANSGENIC MAMMALS AND CELL LINES FOR THE IDENTIFICATION OF GLUTAMATE TRANSPORTER MODULATORS
    Publication number: 20110201043
    Abstract: The invention includes a transgenic, non-human mammal useful for identifying candidate compounds for treating neurological and/or psychiatric disorders. Incorporated into the genome of the transgenic mammal is a transgene comprising a glutamate transporter promoter operatively linked to a reporter gene. The transgenic, non-human mammal and cells isolated therefrom can be used as an in vivo model for the identification of candidate compounds useful for the treatment of neurological and/or psychiatric disorders.
    Type: Application
    Filed: November 12, 2010
    Publication date: August 18, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jeffrey D. Rothstein, Melissa Regan, Shuy Vang Toan
  • EAAT2 promoter and uses thereof
    Patent number: 7723505
    Abstract: The present invention provides nucleic acid molecules comprising the EAAT2 promoter, as well as screening assays useful for identifying compounds which modulate the activity of the EAAT2 promoter, and methods of treating neurological disorders comprising administration of EAAT2 promoter modulators.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: May 25, 2010
    Assignee: The John Hopkins University
    Inventor: Jeffrey D. Rothstein
  • Targeted retrograde gene delivery to motor neurons
    Patent number: 7674455
    Abstract: Methods are disclosed for delivering a heterologous gene to a cell body of a neuron by contacting a muscle tissue innervated by the neuron with a viral vector comprising a heterologous gene, wherein the viral vector enters said neuron and is retrogradely moved to the cell body. Additionally, methods for expressing secreted proteins from a nerve cell body as well as methods for treating neurodegenerative disorders such as amyotrophic lateral sclerosis are described.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: March 9, 2010
    Assignee: Salk Institute for Biological Studies
    Inventors: Brian K. Kaspar, Fred H. Gage, Jeffrey D. Rothstein
  • Glutamate transporter associated protein
    Patent number: 7521536
    Abstract: Glutamate Transporter Associated Proteins and nucleotide encoding Glutamate Transporter Associated Proteins are provided. Also provided is a method for identifying a compound that modulates a cellular response mediated by a Glutamate Transporter Associated Protein. A method is further provided for identifying a compound that inhibits an interaction between a Glutamate Transporter Associated Protein and a glutamate transporter protein. A method is provided for treating a disorder associated with glutamate transport.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: April 21, 2009
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Jeffrey D. Rothstein, Mandy Jackson, Glen Lin, Robert Law, Irina Orlov
  • Target for therapy of cognitive impairment
    Publication number: 20080177061
    Abstract: The invention relates to methods of identifying genes involved in cognitive impairment and compositions for treating cognitive impairment.
    Type: Application
    Filed: March 3, 2008
    Publication date: July 24, 2008
    Inventors: Michela Gallagher, Pauline Kay Lund, Jeffrey D. Rothstein
  • Glutamate transporter associated proteins and methods of use thereof
    Patent number: 7252970
    Abstract: Glutamate Transporter Associated Proteins and nucleotide encoding Glutamate Transporter Associated Proteins are provided. Also provided is a method for identifying a compound that modulates a cellular response mediated by a Glutamate Transporter Associated Protein. A method is further provided for identifying a compound that inhibits an interaction between a Glutamate Transporter Associated Protein and a glutamate transporter protein. A method is provided for treating a disorder associated with glutamate transport.
    Type: Grant
    Filed: October 25, 2004
    Date of Patent: August 7, 2007
    Assignee: The Johns Hopkins University
    Inventors: Jeffrey D. Rothstein, Mandy Jackson, Glen Lin, Robert Law, Irina Orlov
  • Aberrant glutamate transporters and methods of use
    Patent number: 7060457
    Abstract: In one aspect, the present invention features methods for detecting at least one neurological disorder in a patient, the method comprising obtaining a biological sample from the patient; and detecting at least one aberrant human glutamate transporter 2 (EAAT 2) mRNA in the sample as being indicative of the neurological disorder in the patient. In a particular aspect, the invention is useful for detecting amyotrophic lateral sclerosis (ALS) in the patient.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: June 13, 2006
    Assignee: Johns Hopkins University
    Inventors: Jeffrey D. Rothstein, Chieng-Liang Glenn Lin, Lynn A. Bristol
  • Glutamate transporter associated proteins and methods of use thereof
    Patent number: 6808893
    Abstract: Glutamate Transporter Associated Proteins and nucleotide encoding Glutamate Transporter Associated Proteins are provided. Also provided is a method for identifying a compound that modulates a cellular response mediated by a Glutamate Transporter Associated Protein. A method is further provided for identifying a compound that inhibits an interaction between a Glutamate Transporter Associated Protein and a glutamate transporter protein. A method is provided for treating a disorder associated with glutamate transport.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: October 26, 2004
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Jeffrey D. Rothstein, Mandy Jackson, Glen Lin, Robert Law, Irina Orlov
  • Target for therapy of cognitive impairment
    Publication number: 20040191803
    Abstract: The invention relates to methods of identifying genes involved in cognitive impairment and compositions for treating cognitive impairment.
    Type: Application
    Filed: November 24, 2003
    Publication date: September 30, 2004
    Inventors: Michela Gallagher, Pauline Kay Lund, Jeffrey D. Rothstein