Abstract: Methods and structures having and/or implementing integrated steps for use in a planning phase of high throughput research which can provide a process flow that can be used provide statistically defensible and reproducible data in high throughput research. The integrated steps can include quantifying systematic variation in a high throughput research system that is to process a candidate, wherein the high throughput research system has at least one physical attribute and at least one environmental attribute, identifying a design objective for the candidate, and providing an experimental design for the candidate that accounts for the systematic variation to produce the statistically defensible results.

Abstract: Methods and structures having and/or implementing integrated steps for use in a planning phase of experimentation, which can allow the researcher to explore the experimental space while reducing the number experiments performed.