Abstract: The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

Abstract: In one aspect of the present disclosure, a disc brake rotor assembly is provided that includes a disc brake rotor and a wheel hub. One of the disc brake rotor and the wheel hub includes a plurality of pairs of partial keyways and the other of the disc brake rotor and the wheel hub includes intermediate partial keyways configured to fit intermediate the pairs of partial keyways to form keyways. The disc brake rotor assembly further includes a plurality of fasteners configured to be received in the keyways to secure the disc brake rotor and the wheel hub together.

Abstract: A bandgap voltage reference circuit includes first and second transistors (e.g., 3-terminal BJTs or diode-connected BJTs), and a PTAT element (e.g., resistance or capacitance). The first transistor is at a first die location, and operates with a first base-emitter voltage. The second transistor is at a second die location, and operates with a second base-emitter voltage. Each of the first and second transistors may include multiple individual parallel-connected transistors. The PTAT element is operatively coupled to the first and second transistors such that a voltage difference between the first and second base-emitter voltages drops across the PTAT element. The first and second locations are separated by a distance (e.g., 1.5% or more of die length, or such that the respective centroids of the first and second transistor are spaced from one another). Such spatial distribution helps mitigate voltage shift induced by mechanical stress, and is insensitive to process variation.

Abstract: A bandgap voltage reference circuit includes first and second transistors (e.g., 3-terminal BJTs or diode-connected BJTs), and a PTAT element (e.g., resistance or capacitance). The first transistor is at a first die location, and operates with a first base-emitter voltage. The second transistor is at a second die location, and operates with a second base-emitter voltage. Each of the first and second transistors may include multiple individual parallel-connected transistors. The PTAT element is operatively coupled to the first and second transistors such that a voltage difference between the first and second base-emitter voltages drops across the PTAT element. The first and second locations are separated by a distance (e.g., 1.5% or more of die length, or such that the respective centroids of the first and second transistor are spaced from one another). Such spatial distribution helps mitigate voltage shift induced by mechanical stress, and is insensitive to process variation.

Abstract: A fan control system and method that maintains the operating temperature of computer and electronic devices or components at about a predetermined control level to minimize power consumption and audible noise. The fan control system is a programmable closed loop system including a temperature sensor, first and second fan controllers, and a fan/motor assembly including a power converter, a motor, and a fan. The first fan controller provides programmable acceleration/deceleration of the fan during an initial fan spin up, and the second fan controller runs the fan only as fast as necessary to keep the sensed temperature level of a computer device as close as possible to the predetermined control level, thereby minimizing the power consumption of the system and the audible noise of the fan.

Abstract: A fan control system and method that maintains the operating temperature of computer and electronic devices or components at about a predetermined control level to minimize power consumption and audible noise. The fan control system is a programmable closed loop system including a temperature sensor, first and second fan controllers, and a fan/motor assembly including a power converter, a motor, and a fan. The first fan controller provides programmable acceleration/deceleration of the fan during an initial fan spin up, and the second fan controller runs the fan only as fast as necessary to keep the sensed temperature level of a computer device as close as possible to the predetermined control level, thereby minimizing the power consumption of the system and the audible noise of the fan.

Abstract: The temperature of an internally or remotely sensed diode is determined using sequential currents applied to the diode, while compensating for parasitic resistance effects on the sensed diode so that the temperature indication is accurate. A method or circuit is provided which isolates the parasitic resistance value itself or a voltage representative of the parasitic resistance, so that an error compensation value can be obtained for use in subsequent measurements.

Abstract: An improved circuit and method is provided that can increase the slew rate of an operational amplifier without adversely affecting its response time. An operational amplifier comprises a large signal detector, a bias circuit having a bias override component, and a bias decay circuit. As a result, the operational amplifier provides the ability to control the increase in current supplied to its compensation capacitors while also providing a smooth transition to the decay phase. In accordance with an exemplary embodiment of the present invention, an exponential decay to the increased bias condition is provided.

Abstract: An improved circuit and method is provided that can increase the slew rate of an operational amplifier without adversely affecting its response time. An operational amplifier comprises a large signal detector, a bias circuit having a bias override component, and a bias decay circuit. As a result, the operational amplifier provides the ability to control the increase in current supplied to its compensation capacitors while also providing a smooth transition to the decay phase. In accordance with an exemplary embodiment of the present invention, an exponential decay to the increased bias condition is provided.