Patents by Inventor Jeffrey E. Merit

Jeffrey E. Merit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for preparing toll-like receptor modulator compounds
    Patent number: 12590089
    Abstract: The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
    Type: Grant
    Filed: February 16, 2022
    Date of Patent: March 31, 2026
    Assignee: Gilead Sciences, Inc.
    Inventors: Andrea Ambrosi, Florence J. Bachrach, Pavel R. Badalov, Stephen P. Lathrop, Jeffrey E. Merit, Beau P. Pritchett, Christopher S. Regens, Tiago Vieira, Adam B. Weinstein, Todd A. Wenderski, Zehua Zheng
  • PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS
    Publication number: 20260055068
    Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.
    Type: Application
    Filed: August 4, 2025
    Publication date: February 26, 2026
    Inventors: Katrien Brak, Kae M. Bullock, Greg Cizio, Kathy Dao, Darryl D. Dixon, Joshua R. Dunetz, Luke D. Humphreys, Valerie Huynh, Michael A. Ischay, Trevor C. Johnson, Jeffrey E. Merit, Christopher S. Regens, Eric A. Standley, Dietrich P. Steinhuebel, Justin Y. Su, Tao Wu, Marshall D. Young
  • METHODS AND INTERMEDIATES FOR PREPARING THERAPEUTIC COMPOUNDS
    Publication number: 20250296933
    Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of Formula I: or a salt thereof.
    Type: Application
    Filed: February 28, 2025
    Publication date: September 25, 2025
    Inventors: Sanberk S. Atalay, Selcuk Calimsiz, Andrei Chtchemelinine, Wing Chung, Joshua Dahlke, Ian J. Doxsee, Timothy G. Elford, Sean Feng, Kevin J. Garcia, Olivia F. Goethe, Jordan B. Henrie, Joshua R. LeDrew, Jesse W. Li, Lucas Man, Jeffrey E. Merit, Monalisa Munia, Sean T. Neville, Lyubov Roever, Daniel C. Salgueiro, Justin Y. Su, Yibai Sun, Anna Michelle Wagner, Mohammad M. Zahedi
  • Processes and intermediates for preparing MCL1 inhibitors
    Patent number: 12410146
    Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.
    Type: Grant
    Filed: August 1, 2023
    Date of Patent: September 9, 2025
    Assignee: Gilead Sciences, Inc.
    Inventors: Katrien Brak, Kae M. Bullock, Greg Cizio, Kathy Dao, Darryl D. Dixon, Joshua R. Dunetz, Luke D. Humphreys, Valerie Huynh, Michael A. Ischay, Trevor C. Johnson, Jeffrey E. Merit, Christopher S. Regens, Eric A. Standley, Dietrich P. Steinhuebel, Justin Y. Su, Tao Wu, Marshall D. Young
  • PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS
    Publication number: 20250179004
    Abstract: The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.
    Type: Application
    Filed: December 10, 2024
    Publication date: June 5, 2025
    Inventors: Darryl D. Dixon, Michael A. Ischay, Trevor C. Johnson, Jeffrey E. Merit, Christopher S. Regens, Eric A. Standley, Dietrich P. Steinhuebel
  • Processes and intermediates for preparing MCL1 inhibitors
    Patent number: 12202782
    Abstract: The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.
    Type: Grant
    Filed: November 17, 2021
    Date of Patent: January 21, 2025
    Assignee: Gilead Sciences, Inc.
    Inventors: Darryl D. Dixon, Michael A. Ischay, Trevor C. Johnson, Jeffrey E. Merit, Christopher S. Regens, Eric A. Standley, Dietrich P. Steinhuebel
  • PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS
    Publication number: 20240109851
    Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.
    Type: Application
    Filed: August 1, 2023
    Publication date: April 4, 2024
    Inventors: Katrien Brak, Kae M. Bullock, Greg Cizio, Kathy Dao, Darryl D. Dixon, Joshua R. Dunetz, Luke D. Humphreys, Valerie Huynh, Michael A. Ischay, Trevor C. Johnson, Jeffrey E. Merit, Christopher S. Regens, Eric A. Standley, Dietrich P. Steinhuebel, Justin Y. Su, Tao Wu, Marshall D. Young
  • Processes and intermediates for preparing MCL1 inhibitors
    Patent number: 11760736
    Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.
    Type: Grant
    Filed: March 22, 2022
    Date of Patent: September 19, 2023
    Assignee: Gilead Sciences, Inc.
    Inventors: Katrien Brak, Kae M. Bullock, Greg Cizio, Kathy Dao, Darryl D. Dixon, Joshua R. Dunetz, Luke D. Humphreys, Valerie Huynh, Michael A. Ischay, Trevor C. Johnson, Jeffrey E. Merit, Christopher S. Regens, Eric A. Standley, Dietrich P. Steinhuebel, Justin Y. Su, Tao Wu, Marshall D. Young
  • PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS
    Publication number: 20230013713
    Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.
    Type: Application
    Filed: March 22, 2022
    Publication date: January 19, 2023
    Inventors: Katrien Brak, Kae M. Bullock, Greg Cizio, Kathy Dao, Darryl D. Dixon, Joshua R. Dunetz, Luke D. Humphreys, Valerie Huynh, Michael A. Ischay, Trevor C. Johnson, Jeffrey E. Merit, Christopher S. Regens, Eric A. Standley, Dietrich P. Steinhuebel, Justin Y. Su, Tao Wu, Marshall D. Young
  • PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS
    Publication number: 20220274985
    Abstract: The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
    Type: Application
    Filed: February 16, 2022
    Publication date: September 1, 2022
    Inventors: Andrea Ambrosi, Florence J. Bachrach, Pavel R. Badalov, Stephen P. Lathrop, Jeffrey E. Merit, Beau P. Pritchett, Christopher S. Regens, Tiago Vieira, Adam B. Weinstein, Todd A. Wenderski, Zehua Zheng
  • PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS
    Publication number: 20220177409
    Abstract: The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.
    Type: Application
    Filed: November 17, 2021
    Publication date: June 9, 2022
    Inventors: Darryl D. Dixon, Michael A. Ischay, Trevor C. Johnson, Jeffrey E. Merit, Christopher S. Regens, Eric A. Standley, Dietrich P. Steinhuebel
  • Processes and intermediates for preparing MCL1 inhibitors
    Patent number: 11325891
    Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.
    Type: Grant
    Filed: November 20, 2020
    Date of Patent: May 10, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Katrien Brak, Kae M. Bullock, Greg Cizio, Kathy Dao, Darryl D. Dixon, Joshua R. Dunetz, Luke D. Humphreys, Valerie Huynh, Michael A. Ischay, Trevor C. Johnson, Jeffrey E. Merit, Christopher S. Regens, Eric A. Standley, Dietrich P. Steinhuebel, Justin Y. Su, Tao Wu, Marshall D. Young
  • Processes for preparing toll-like receptor modulator compounds
    Patent number: 11286257
    Abstract: The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: March 29, 2022
    Assignee: Gilead Sciences, Inc.
    Inventors: Andrea Ambrosi, Florence J. Bachrach, Pavel R. Badalov, Stephen P. Lathrop, Jeffrey E. Merit, Beau P. Pritchett, Christopher S. Regens, Tiago Vieira, Adam B. Weinstein, Todd A. Wenderski, Zehua Zheng
  • PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS
    Publication number: 20210179570
    Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.
    Type: Application
    Filed: November 20, 2020
    Publication date: June 17, 2021
    Inventors: Katrien Brak, Kae M. Bullock, Greg Cizio, Kathy Dao, Darryl D. Dixon, Joshua R. Dunetz, Luke D. Humphreys, Valerie Huynh, Michael A. Ischay, Trevor C. Johnson, Jeffrey E. Merit, Christopher S. Regens, Eric A. Standley, Dietrich P. Steinhuebel, Justin Y. Su, Tao Wu, Marshall D. Young
  • PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS
    Publication number: 20210017170
    Abstract: The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
    Type: Application
    Filed: June 25, 2020
    Publication date: January 21, 2021
    Inventors: Evangelos Aktoudianakis, Andrea Ambrosi, Sylvie M. Asselin, Florence J. Bachrach, Pavel R. Badalov, Gregory F. Chin, Stephen P. Lathrop, Willard Lew, Richard L. Mackman, Jeffrey E. Merit, Samuel E. Metobo, Michael R. Mish, Beau P. Pritchett, Hyung-Jung Pyun, Christopher S. Regens, Tiago Vieira, Xianghong Wang, Adam B. Weinstein, Todd A. Wenderski, Zehua Zheng
  • Pyrazole compounds and methods of making and using same
    Patent number: 10385057
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: August 20, 2019
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Cheryl A. Grice, Todd K. Jones, Katharine K. Duncan, Olivia D. Weber, Justin S. Cisar, Jeffrey E. Merit
  • Pyrazole compounds and methods of making and using same
    Patent number: 10323038
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: June 18, 2019
    Assignee: ABIDE THERAPEUTICS, INC.
    Inventors: Cheryl A. Grice, Todd K. Jones, Katharine K. Duncan, Justin S. Cisar, Jeffrey E. Merit, Olivia D. Weber
  • PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20180327410
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
    Type: Application
    Filed: November 18, 2016
    Publication date: November 15, 2018
    Inventors: Cheryl A. GRICE, Todd K. JONES, Katherine K. DUNCAN, Olivia D. WEBER, Justin S. CISAR, Jeffrey E. MERIT
  • PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20180327416
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
    Type: Application
    Filed: November 18, 2016
    Publication date: November 15, 2018
    Inventors: Cheryl A. GRICE, Todd K. JONES, Katharine K. DUNCAN, Justin S. CISAR, Jeffrey E. MERIT, Olivia D. WEBER
  • 10?,11?-modified saxitoxins useful for the treatment of pain
    Patent number: 10106549
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function, for example conditions associated with pain. The compounds are 10?,11?-modified saxitoxins. The compounds are optionally additionally modified at carbon 13. In certain embodiments, the 10?,11?-modified saxitoxins are of Formula I: where R1, R2 and R3 are as described herein. Also provided herein are methods of treating pain in a mammal comprising administering an effective treatment amount of a 10?,11? modified saxitoxin or composition to a mammal. In an embodiment, the mammal is a human.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: October 23, 2018
    Assignees: SITEONE THERAPEUTICS, INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Hassan Pajouhesh, George Miljanich, John Mulcahy, Justin Du Bois, Matthew Axtman, James Walker, Jeffrey E. Merit