Patents by Inventor Jeffrey E. Saffitz

Jeffrey E. Saffitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLUBLE EPOXIDE HYDROLASE (sEH) INHIBITORS AND DUAL COX/sEH INHIBITORS FOR THE TREATMENT OF ARRHYTHMOGENIC CARDIOMYOPATHY
    Publication number: 20240024302
    Abstract: Provided herein are methods of preventing, mitigating, decreasing, reversing and/or treating Arrhythmogenic Cardiomyopathy (ACM) in a subject in need thereof, comprising administering to the subject an effective amount of a compound of Formula I, a compounds of Formula II, or a compound of Formula III (I) (II), (III) wherein R1, R2, R3, n, R4, R4a, R5, m, R6, R7, and p are as defined herein.
    Type: Application
    Filed: October 25, 2021
    Publication date: January 25, 2024
    Inventors: Jeffrey E. SAFFITZ, Bruce D. HAMMOCK, Sung Hee HWANG
  • ANTI-INFLAMMATORY THERAPY IN ARRHYTHMOGENIC CARDIOMYOPATHY (ACM)
    Publication number: 20220356240
    Abstract: Described herein are, inter alia, methods for treating arrhythmogenic cardiomyopathy (ACM) using anti-inflammatory agents that IL-1?.
    Type: Application
    Filed: September 25, 2020
    Publication date: November 10, 2022
    Inventor: Jeffrey E. Saffitz
  • ANTI-INFLAMMATORY THERAPY IN ARRHYTHMOGENIC CARDIOMYOPATHY (ACM)
    Publication number: 20210161868
    Abstract: Described herein are, inter alia, methods for treating arrhythmogenic cardiomyopathy (ACM) using anti-inflammatory agents that target nuclear factor-kappa-B (NFkB).
    Type: Application
    Filed: April 25, 2019
    Publication date: June 3, 2021
    Inventor: Jeffrey E. Saffitz
  • Buccal cell diagnosis of arrhythmogenic cardiomyopathy (ACM)
    Patent number: 10317417
    Abstract: Described herein are, inter alia, methods for diagnosing and treating arrhythmogenic cardiomyopathy (ACM) by detecting cardiac intercalated disk proteins, e.g., desmosomal proteins, mechanical and gap junction proteins, in buccal cells. Exemplary desmosomal and gap junction proteins that can be evaluated in the methods described herein include plakoglobin, plakophilin 1, desmoplakin, and Cx43. The methods can also include selecting and/or administering a treatment for ACM to the subject.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: June 11, 2019
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Jeffrey E. Saffitz, Angeliki Asimaki
  • BUCCAL CELL DIAGNOSIS OF ARRHYTHMOGENIC CARDIOMYOPATHY (ACM)
    Publication number: 20180259539
    Abstract: Described herein are, inter alia, methods for diagnosing and treating arrhythmogenic cardiomyopathy (ACM) by detecting cardiac intercalated disk proteins, e.g., desmosomal proteins, mechanical and gap junction proteins, in buccal cells. Exemplary desmosomal and gap junction proteins that can be evaluated in the methods described herein include plakoglobin, plakophilin 1, desmoplakin, and Cx43. The methods can also include selecting and/or administering a treatment for ACM to the subject.
    Type: Application
    Filed: May 14, 2018
    Publication date: September 13, 2018
    Inventors: Jeffrey E. Saffitz, Angeliki Asimaki
  • Buccal cell diagnosis of arrhythmogenic cardiomyopathy (ACM)
    Patent number: 9995756
    Abstract: Described herein are, inter alia, methods for diagnosing and treating arrhythmogenic cardiomyopathy (ACM) by detecting cardiac intercalated disk proteins, e.g., desmosomal proteins, mechanical and gap junction proteins, in buccal cells. Exemplary desmosomal and gap junction proteins that can be evaluated in the methods described herein include plakoglobin, plakophilin 1, desmoplakin, and Cx43. The methods can also include selecting and/or administering a treatment for ACM to the subject.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: June 12, 2018
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Jeffrey E. Saffitz, Angeliki Asimaki
  • Buccal Cell Diagnosis of Arrhythmogenic Cardiomyopathy (ACM)
    Publication number: 20170097363
    Abstract: Described herein are, inter alia, methods for diagnosing and treating arrhythmogenic cardiomyopathy (ACM) by detecting cardiac intercalated disk proteins, e.g., desmosomal proteins, mechanical and gap junction proteins, in buccal cells. Exemplary desmosomal and gap junction proteins that can be evaluated in the methods described herein include plakoglobin, plakophilin 1, desmoplakin, and Cx43. The methods can also include selecting and/or administering a treatment for ACM to the subject.
    Type: Application
    Filed: September 27, 2016
    Publication date: April 6, 2017
    Inventors: Jeffrey E. Saffitz, Angeliki Asimaki