Abstract: Disclosed herein are methods for isolating DNA, such as cell-free DNA (cfDNA) or DNA from a tissue sample, e.g., in which the DNA is partitioned into hypermethylated and hypomethylated partitions. After differential tagging of the partitions, portions of the hypomethylated partition are pooled with the hypermethylated partition or pooled separately. Epigenetic and sequence-variable target regions are captured from the pool comprising DNA from the hypermethylated and hypomethylated partitions, and sequence-variable target regions are captured from the pool comprising DNA from the hypomethylated partition. This approach can reduce costs and/or bandwidth by limiting sequencing of epigenetic target regions from the hypomethylated partition, which may be less informative than other DNA.

Abstract: Embodiments of the invention relate to methods and systems for providing customized “haptic messaging” to users of handheld communication devices in a variety of applications. In one embodiment, a method of providing virtual touch to a handheld communication device includes: receiving an input signal associated with a virtual touch; outputting a request relating to a contact with a user-interface member coupled to a handheld communication device; and providing a control signal associated with the contact to an actuator coupled to the handheld communication device, the control signal being configured to cause the actuator to output a haptic effect associated with the virtual touch.

Abstract: Embodiments of the invention relate to methods and systems for providing customized “haptic messaging” to users of handheld communication devices in a variety of applications. In one embodiment, a method of haptic messaging includes: receiving an input signal associated with an actuation of a user-interface member; determining a haptic code associated with the actuation; and including the haptic code in an output signal to be sent to a remote handheld communication device. In another embodiment, a method of haptic messaging includes: receiving an input signal; outputting a request relating to a contact with a user-interface member coupled to a handheld communication device; and providing a control signal associated with the contact to an actuator coupled to the handheld communication device, the control signal being configured to cause the actuator to output a haptic effect associated with the input signal.

Abstract: Embodiments of the invention relate to methods and systems for providing customized “haptic messaging” to users of handheld communication devices in a variety of applications. In one embodiment, a method of providing haptic messaging to a hand communication device includes: associating an input signal with an event; determining a source of the event and selecting the control signal based on the determination; and outputting a control signal to an actuator coupled to the hand communication device. The control signal is configured to cause the actuator to output a haptic effect associated with the event. An event in the above may be a connection event.

Abstract: Embodiments of the invention relate to methods and systems for providing customized “haptic messaging” to users of handheld communication devices in a variety of applications. In one embodiment, businesses and organizations may each be associated with a distinct haptic logo and include their haptic logos in various messages sent to the handheld communication devices of their customers. In another embodiment, haptically-enabled avatars can be used in a chat session between users of handheld communication devices.

Abstract: Embodiments of the invention relate to methods and systems for providing customized “haptic messaging” to users of handheld communication devices in a variety of applications. In one embodiment, a method of providing haptic messaging to a hand communication device includes: receiving an input signal associated with an event; determining a source of the event and selecting the control signal based on the determination; and outputting a control signal to an actuator coupled to the hand communication device. The control signal is configured to cause the actuator to output a haptic effect associated with the reminder event. An event in the above may be a reminder event or a status event.

Abstract: Embodiments of the invention relate to methods and systems for providing customized “haptic messaging” to users of handheld communication devices in a variety of applications. In one embodiment, a method of providing haptic messaging to a hand communication device includes: associating an input signal with an event; determining a source of the event and selecting the control signal based on the determination; and outputting a control signal to an actuator coupled to the hand communication device. The control signal is configured to cause the actuator to output a haptic effect associated with the event. An event in the above may be a connection event.

Abstract: Embodiments of the invention relate to methods and systems for providing customized “haptic messaging” to users of handheld communication devices in a variety of applications. In one embodiment, businesses and organizations may each be associated with a distinct haptic logo and include their haptic logos in various messages sent to the handheld communication devices of their customers. In another embodiment, haptically-enabled avatars can be used in a chat session between users of handheld communication devices.

Abstract: Embodiments of the invention relate to methods and systems (100) for providing customized “haptic messaging” to use of handheld communication devices in a variety of applications. In one embodiment, a method of providing virtual touch to a handheld communication device includes: receiving an input signal associated with a virtual touch; outputing a request relating to a contact with a user-interface member coupled to a handheld communication device; and providing a control signal associated with the contact to an actuator coupled to the handheld communication device, the control signal being configured to cause the actuator to output a haptic effect associated with the virtual touch.

Abstract: Embodiments of the invention relate to methods and systems for providing customized “haptic messaging” to users of handheld communication devices (110) in a variety of applications. In one embodiment, a method of haptic messaging includes: receiving an input signal associated with an actuation of a user-interface member (112); determining a haptic code associated with the actuation; and including the haptic code in an output signal to be sent to a remote handheld communication device (10). In another embodiment, a method of haptic messaging includes: receiving an input signal; outputting a request relating to a contact with a user-interface member (112) coupled to a handheld communication device (110); and providing a control signal associated with the contact to an actuator (130) coupled to the handheld communication device (110), the control signal being configured to cause the actuator (130) to output a haptic effect associated with the input signal.

Abstract: Embodiments of the invention relate to methods and systems for providing customized “haptic messaging” to users of handheld communication devices in a variety of applications. In one embodiment, a method of providing haptic messaging to a hand communication device includes: associating an input signal with an event; determining a source of the event and selecting the control signal based on the determination; and outputting a control signal to an actuator coupled to the hand communication device. The control signal is configured to cause the actuator to output a haptic effect associated with the event. An event in the above may be a service carrier event.

Abstract: In one embodiment, a method for mapping between an event of interest and a corresponding haptic effect includes: providing a plurality of haptic effects to a user; allowing a user to associate haptic effects with one or more events of interest; and compiling the mappings made between various events of interest and corresponding haptic effects into a haptic lookup table, storable in memory.

Abstract: Embodiments of the invention relate to methods and systems for providing customized “haptic messaging” to users of handheld communication devices in a variety of applications. In one embodiment, a method of providing haptic messaging to a hand communication device includes: associating an input signal with an event; determining a source of the event and selecting the control signal based on the determination; and outputting a control signal to an actuator coupled to the hand communication device. The control signal is configured to cause the actuator to output a haptic effect associated with the event. An event in the above may be a user interface navigation event.