Abstract: [Problem] To develop novel therapeutic agents for viral diseases such as coronavirus infections. [Solution] The present invention provides a therapeutic or prophylactic agent for viral diseases containing a compound with inhibitory activity against the function of Pin1 or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract: Reagents which regulate human RC Kinase activity and reagents which bind to human RC Kinase gene products can be used to regulate this protein for therapeutic effects. Such regulation is particularly useful for treating chronic obstructive pulmonary disease, asthma, cancer, and diseases in which cell signaling is defective.

Abstract: Reagents which regulate human RC Kinase activity and reagents which bind to human RC Kinase gene products can be used to regulate this protein for therapeutic effects. Such regulation is particularly useful for treating chronic obstructive pulmonary disease, asthma, cancer, and diseases in which cell signaling is defective.

Abstract: Reagents which regulate human P2Y15 G protein-coupled receptor can play a role in preventing, ameliorating, or correcting bronchoconstriction or inflammation in diseases such as allergies including but not limited to asthma. Further, such reagents is useful to treat diseases of kidney function or disease related to mast cell.

Abstract: Reagents that regulate human ceramide kinase protein activity and reagents that bind to human ceramide kinase gene products can be used to regulate intracellular signaling and consequently cell proliferation and apoptosis. Such regulation is particularly useful for treating allergies including but not limited to asthma, autoimmune diseases such as rheumatoid arthritis, inflammatory disease, transplant rejection, and cancer, particularly lymphocytic leukemias, and could be a useful target of vaccination enhancing adjuvants. Central and peripheral nervous system disorders, such as Parkinson's disease, also can be treated.

Abstract: Reagents which regulate human transient receptor potential channel and reagents which bind to human transient receptor potential channel gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, urinary incontinence, overactive bladder, benign prostatic hyperplasia, lower urinary tract syndromes, and CNS disorders.

Abstract: Disclosed are novel nucleic acid and amino acid sequences of immune-related proteins. Reagents that bind to immune-related gene products can be used to treat conditions involving inflammatory processes, such as allergy, asthma, autoimmune diseases, and other chronic inflammatory diseases where an over-activation or prolongation of the activation of the immune system causes damage to tissues.

Abstract: Reagents that regulate human ceramide kinase protein activity and reagents that bind to human ceramide kinase gene products can be used to regulate intracellular signaling and consequently cell proliferation and apoptosis. Such regulation is particularly useful for treating allergies including but not limited to asthma, autoimmune diseases such as rheumatoid arthritis, inflammatory disease, transplant rejection, and cancer, particularly lymphocytic leukemias, and could be a useful target of vaccination enhancing adjuvants. Central and peripheral nervous system disorders, such as Parkinson's disease, also can be treated.

Abstract: Reagents which regulate human B7-H2 and reagents which bind to human B7-H2 gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, allergic diseases, such as respiratory allergies, food allergies, asthma, and atopic dermatitis, as well as in the treatment of intracellular bacterial infections, such as tuberculosis, leprosy, listeriosis, and salmonellosis; and autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and type I diabetes, as well as in the treatment of helminth and extracellular microbial infections.

Abstract: Reagents which regulate human chemokine-like receptor and reagents which bind to human chemokine-like receptor gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, HIV infection, cardiovascular disorders, asthma and COPD.

Abstract: Disclosed are novel nucleic acid and amino acid sequences of an endothelial differentiation gene 6 (EDG6)-like G protein coupled receptor. Reagents that bind to EDG6-like receptor gene products can be used to treat conditions involving inflammatory processes, such as allergy, asthma, autoinamune diseases, and other chronic inflammatory diseases where an over-activation or prolongation of the activation of the immune system causes damage to tissues.

Abstract: Reagents which regulate human sphingosine kinase-like protein activity and reagents which bind to human sphingosine kinase-like gene products can be used to regulate intracellular signaling and consequently cell proliferation and apoptosis. Such regulation is particularly useful for treating cancer, allergies including but not limited to asthma, autoimmune diseases such as rheumatoid arthritis, and central and peripheral nervous system disorders, such as Parkinson's disease.

Abstract: Disclosed are novel nucleic acid and amino acid sequences of NF-AT interacting protein NIP 45 variants. Reagents that bind to NIP45-variant gene products can be used to treat conditions involving inflammatory processes, such as allergy, asthma, autoimmune diseases, and other chronic inflammatory diseases where an over-activation or prolongation of the activation of the immune system causes damage to tissues.