Abstract: An unmanned aerial signal relay includes an unmanned aerial vehicle, including a communication relay unit and at least one antenna, communicatively connected to the communication relay unit; a tether comprising at least two wires and at least one fiber optic cable, the wires and cable communicatively connected to the unmanned aerial vehicle; and a surface support system comprising a spool physically connected to the tether and a ground-based receiver communicatively connected to the at least one fiber optic cable, wherein the unmanned aerial vehicle is powered by electrical energy provided by the at least two wires, and wherein the communication relay unit is configured to relay signals received from the at least one antenna via the fiber optic cable to the ground-based receiver. Various systems and methods related to an unmanned aerial signal relay are also described.

Abstract: An unmanned aerial signal relay includes an unmanned aerial vehicle, including a communication relay unit and at least one antenna, communicatively connected to the communication relay unit; a tether comprising at least two wires and at least one fiber optic cable, the wires and cable communicatively connected to the unmanned aerial vehicle; and a surface support system comprising a spool physically connected to the tether and a ground-based receiver communicatively connected to the at least one fiber optic cable, wherein the unmanned aerial vehicle is powered by electrical energy provided by the at least two wires, and wherein the communication relay unit is configured to relay signals received from the at least one antenna via the fiber optic cable to the ground-based receiver. Various systems and methods related to an unmanned aerial signal relay are also described.

Abstract: An unmanned aerial signal relay includes an unmanned aerial vehicle, including a communication relay unit and at least one antenna, communicatively connected to the communication relay unit; a tether comprising at least two wires and at least one fiber optic cable, the wires and cable communicatively connected to the unmanned aerial vehicle; and a surface support system comprising a spool physically connected to the tether and a ground-based receiver communicatively connected to the at least one fiber optic cable, wherein the unmanned aerial vehicle is powered by electrical energy provided by the at least two wires, and wherein the communication relay unit is configured to relay signals received from the at least one antenna via the fiber optic cable to the ground-based receiver. Various systems and methods related to an unmanned aerial signal relay are also described.

Abstract: Methods of treating or preventing cancer, or treating or preventing noncancerous tumors or lesions, in a subject in need thereof. The methods involve administering a therapeutically effective amount of one or more inhibitors of the YAP/TAZ pathway to the subject. In addition, methods of inhibiting or preventing glycolysis in cancer cells in a subject, promoting mitochondrial respiration in cancer cells in a subject, and promoting oxidative stress in cancer cells in a subject, by administering a therapeutically effective amount of one or more inhibitors of the YAP/TAZ pathway to the subject.

Abstract: An unmanned aerial signal relay includes an unmanned aerial vehicle, including a communication relay unit and at least one antenna, communicatively connected to the communication relay unit; a tether comprising at least two wires and at least one fiber optic cable, the wires and cable communicatively connected to the unmanned aerial vehicle; and a surface support system comprising a spool physically connected to the tether and a ground-based receiver communicatively connected to the at least one fiber optic cable, wherein the unmanned aerial vehicle is powered by electrical energy provided by the at least two wires, and wherein the communication relay unit is configured to relay signals received from the at least one antenna via the fiber optic cable to the ground-based receiver. Various systems and methods related to an unmanned aerial signal relay are also described.

Abstract: A method of improving the cosmetic appearance of human teeth comprising the step of contacting the teeth with a whitening powder composition after ingesting a chromogenic, tannin-containing food or beverage and thereby reducing staining of the teeth caused by tannins and/or chromogens. The tooth-whitening tablet is comprised of (i) at least one abrasive powder; (ii) at least one buffering powder; (iii) a complexing agent; and, optionally, (iv) an anti-cavity sweetener.

Abstract: A bag for carrying and storing an umbrella includes an elongated, tubular sleeve portion with an open end and a closed end defining an interior sized to accommodate the umbrella. The opened end can receive the umbrella lengthwise into the interior. Attached to the closed end can be an end cap having a central drainage aperture disposed therethrough. The drainage aperture can sealingly engage with an elongated tip on the umbrella to retain moisture from the umbrella within the interior of the bag. The umbrella tip can be selectively removed from and inserted into the drainage aperture to selectively seal and unseal the drainage aperture. In some embodiments, a sealing gasket can be disposed in the end cap to facilitate sealing of the drainage aperture.

Abstract: This invention relates to therapeutic infusion assemblies, more specifically a device for the subcutaneous delivery of a fluid from a remote source. Applicant provides a base assembly which has a fluid channel therein and a cannula extending vertically downward from a flat bottom. A fluid connector member which receives a fluid bearing line from the remote fluid source and the fluid connector member pivotably and removably connects to the base member. The manner of connection is “hinged” allowing the fluid connector to move from a non-use position by rotation downward to a used position. In the use position a fluid channel in the fluid connector will connect with a fluid channel in the base to provide fluid to the cannula and to the patient.

Abstract: This invention relates to therapeutic infusion assemblies, more specifically a device for the subcutaneous delivery of a fluid from a remote source. Applicant provides a base assembly which has a fluid channel therein and a cannula extending vertically downward from a flat bottom. A fluid connector member which receives a fluid bearing line from the remote fluid source and the fluid connector member pivotably and removably connects to the base member. The manner of connection is “hinged” allowing the fluid connector to move from a non-use position by rotation downward to a used position. In the use position a fluid channel in the fluid connector will connect with a fluid channel in the base to provide fluid to the cannula and to the patient.

Abstract: This invention relates to therapeutic infusion assemblies, more specifically a device for the subcutaneous delivery of a fluid from a remote source. Applicant provides a base assembly which has a fluid channel therein and a cannula extending vertically downward from a flat bottom. A fluid connector member which receives a fluid bearing line from the remote fluid source and the fluid connector member pivotably and removably connects to the base member. The manner of connection is “hinged” allowing the fluid connector to move from a non-use position by rotation downward to a used position. In the use position a fluid channel in the fluid connector will connect with a fluid channel in the base to provide fluid to the cannula and to the patient.

Abstract: A controlled volume injection/aspiration device includes a syringe having a body for containing a medicament, a needle and a piston slidably disposed within the body. A shell is provided for receiving the syringe body and a plunger rack is disposed within the shell. A manually operated control is disposed in an operative relationship with the plunger rack for moving the plunger rack in a stepwise forward direction causing the piston to eject discrete doses of medication from the syringe body through the needle. The manual operated control is also operative for moving the piston in a stepwise reverse direction causing the piston to aspirate fluid into the syringe body through the needle.

Abstract: A controlled volume injection/aspiration device includes a syringe having a body for containing a medicament, a needle and a piston slidably disposed within the body. A shell is provided for receiving the syringe body and a plunger rack is disposed within the shell. A manually operated control is disposed in an operative relationship with the plunger rack for moving the plunger rack in a stepwise forward direction causing the piston to eject discrete doses of medication from the syringe body through the needle. The manual operated control is also operative for moving the piston in a stepwise reverse direction causing the piston to aspirate fluid into the syringe body through the needle.

Abstract: A controlled volume injection/aspiration device includes a syringe having a body for containing a medicament, a needle and a piston slidably disposed within the body. A shell is provided for receiving the syringe body and a plunger rack is disposed within the shell. A manually operated control is disposed in an operative relationship with the plunger rack for moving the plunger rack in a stepwise forward direction causing the piston to eject discrete doses of medication from the syringe body through the needle. The manual operated control is also operative for moving the piston in a stepwise reverse direction causing the piston to aspirate fluid into the syringe body through the needle.

Abstract: This invention relates to therapeutic infusion assemblies, more specifically a device for the subcutaneous delivery of a fluid from a remote source. Applicant provides a base assembly which has a fluid channel therein and a cannula extending vertically downward from a flat bottom. A fluid connector member which receives a fluid bearing line from the remote fluid source and the fluid connector member pivotably and removably connects to the base member. The manner of connection is “hinged” allowing the fluid connector to move from a non-use position by rotation downward to a used position. In the use position a fluid channel in the fluid connector will connect with a fluid channel in the base to provide fluid to the cannula and to the patient.

Abstract: An insertion device and insertion set. The insertion device for inserting at least a portion of at least one piercing member of an insertion set through the skin of a patient includes a device housing, a carrier body and a driver. The carrier body is slidably received within the device housing for movement between an advanced position and a retracted position. The carrier body also includes a receiving structure to support the insertion set in a position with the at least one piercing member oriented for insertion through the skin of the patient at a predetermined angle relative to the skin of the patient upon movement of the carrier body from the retracted position to the advanced position.

Abstract: This invention relates to therapeutic infusion assemblies, more specifically a device for the subcutaneous delivery of a fluid from a remote source. Applicant provides a base assembly which has a fluid channel therein and a cannula extending vertically downward from a flat bottom. A fluid connector member which receives a fluid bearing line from the remote fluid source and the fluid connector member pivotably and removably connects to the base member. The manner of connection is “hinged” allowing the fluid connector to move from a non-use position by rotation downward to a used position. In the use position a fluid channel in the fluid connector will connect with a fluid channel in the base to provide fluid to the cannula and to the patient.

Abstract: A system for delivery of therapeutic and/or diagnostic agents into a living body includes a port assembly having a cannula extending from the mounting side, a port opening away from the mounting side and a resilient barrier between the port and the cannula. An access hub includes a connector positionable at the port for opening the resilient barrier. The access hub is movable in the port assembly, is engaged therewith through a resilient ring coupling and forms a seal with the resilient barrier, reducing the amount of volume to be primed. Inserters, both disposable and reusable, include the cannula insertion member as part of the assembly. A spring loaded port driver is operatively mounted within the housing with movement controlled by a latch. The driver includes a seat for receipt of a port assembly. The cannula insertion member is nonremovably fixed in a socket in the port driver in the disposable assembly.

Abstract: A system for delivery of therapeutic and/or diagnostic agents into a living body includes a port assembly having a cannula extending from the mounting side, a port opening away from the mounting side and a resilient barrier between the port and the cannula. An access hub includes a connector positionable at the port for opening the resilient barrier. The access hub is movable in the port assembly, is engaged therewith through a resilient ring coupling and forms a seal with the resilient barrier, reducing the amount of volume to be primed. Inserters, both disposable and reusable, include the cannula insertion member as part of the assembly. A spring loaded port driver is operatively mounted within the housing with movement controlled by a latch. The driver includes a seat for receipt of a port assembly. The cannula insertion member is nonremovably fixed in a socket in the port driver in the disposable assembly.

Abstract: A system for delivery of therapeutic and/or diagnostic agents into a living body includes a port assembly having a cannula extending from the mounting side, a port opening away from the mounting side and a resilient barrier between. the port and the cannula. An access hub includes a connector positionable at the port for opening the resilient barrier. The access hub is movable in the port assembly, is engaged therewith through a resilient ring coupling and forms a seal with the resilient barrier, reducing the amount of volume to be primed. Inserters, both disposable and reusable, include the cannula insertion member as part of the assembly. A spring loaded port driver is operatively mounted within the housing with movement controlled by a latch. The driver includes a seat for receipt of a port assembly. The cannula insertion member is nonremovably fixed in a socket in the port driver in the disposable assembly.

Abstract: An insertion device and insertion set. The insertion device for inserting at least a portion of at least one piercing member of an insertion set through the skin of a patient includes a device housing, a carrier body and a driver. The carrier body is slidably received within the device housing for movement between an advanced position and a retracted position. The carrier body also includes a receiving structure to support the insertion set in a position with the at least one piercing member oriented for insertion through the skin of the patient at a predetermined angle relative to the skin of the patient upon movement of the carrier body from the retracted position to the advanced position.