Patents by Inventor Jeffrey Flier

Jeffrey Flier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS CONTAINING ALPHA-1-ANTITRYPSIN AND METHODS FOR USE
    Publication number: 20140147441
    Abstract: Methods and compositions for treating patients (e.g., patients who are insulin resistant, patients who have diabetes, or are at risk for developing diabetes) are disclosed herein. The methods can include administration of an ?1 antitrypsin (AAT) polypeptide or an agent, such as a nucleic acid molecule or organic compound, that promotes the expression or activity of ?1-antitrypsin.
    Type: Application
    Filed: November 19, 2013
    Publication date: May 29, 2014
    Applicants: The General Hospital Corporation, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Jeffrey Flier, Maria Koulmanda, Terry B. Strom
  • Compositions containing ?-1-antitrypsin and methods for use
    Patent number: 8623830
    Abstract: Methods and compositions for treating patients (e.g., patients who are insulin resistant, patients who have diabetes, or are at risk for developing diabetes) are disclosed herein. The methods can include administration of an a1 antitrypsin (AAT) polypeptide or an agent, such as a nucleic acid molecule or organic compound, that promotes the expression or activity of a1-antitrypsin.
    Type: Grant
    Filed: September 12, 2007
    Date of Patent: January 7, 2014
    Assignees: Beth Israel Deaconess Medical Center, Inc., The General Hospital Corporation
    Inventors: Jeffrey Flier, Maria Koulmanda, Terry B. Strom
  • METHODS AND COMPOSITIONS FOR MODIFYING T CELL IMMUNE RESPONSES AND INFLAMMATION
    Publication number: 20110020269
    Abstract: Methods and compositions for immune modulation are described herein. The compositions encompass pharmaceutical compositions that include a combination of agents. The first agent can selectively stimulate regulatory T cells or selectively inhibit inflammatory T cells and the second agent can reduce an inflammatory response in a tissue of a patient to whom the composition is administered. The second agent can reduce the expression or activity of a pro-inflammatory cytokine, promote the expression or activity of an anti-inflammatory cytokine, or both.
    Type: Application
    Filed: May 8, 2008
    Publication date: January 27, 2011
    Applicant: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Terry B. Strom, Jeffrey Flier, Marie Koulmanda
  • COMPOSITIONS CONTAINING ALPHA-1-ANTITRYPSIN AND METHODS FOR USE
    Publication number: 20100111940
    Abstract: Methods and compositions for treating patients (e.g., patients who are insulin resistant, patients who have diabetes, or are at risk for developing diabetes) are disclosed herein. The methods can include administration of an a1 antitrypsin (AAT) polypeptide or an agent, such as a nucleic acid molecule or organic compound, that promotes the expression or activity of a1-antitrypsin.
    Type: Application
    Filed: September 12, 2007
    Publication date: May 6, 2010
    Applicants: BETH ISRAEL DEACONESS MEDICAL CENTER, INC., THE GENERAL HOSPITAL CORPORATION
    Inventors: Jeffrey Flier, Maria Koulmanda, Terry B. Strom
  • Isolation of the peroxisome proliferation-activated receptor-gamma (PPARgamma) ligand and methods of use thereof
    Publication number: 20050192349
    Abstract: The present invention is drawn toward novel endogenous PPAR? ligand, the isolation of the ligand and the use of the isolated ligand to stimulate PPAR? activity in cells of interest. The invention is also drawn to diagnostic methods to detect the level of the ligand in a sample of interest.
    Type: Application
    Filed: December 20, 2004
    Publication date: September 1, 2005
    Applicant: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Jeffrey Flier, Hui Fang, Mario Ollero, Anthony Hollenberg
  • Regulation of eating behavior
    Publication number: 20040242487
    Abstract: MCH and anlogs thereof in the regulation of eating and weight.
    Type: Application
    Filed: July 7, 2004
    Publication date: December 2, 2004
    Applicant: Joslin Diabetes Center, Inc., a Massachusetts corporation
    Inventors: Eleftheria Maratos-Flier, Jeffrey Flier