Patents by Inventor Jeffrey Frelinger

Jeffrey Frelinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANIMAL MODEL SYSTEM AND USES THEREOF
    Publication number: 20200023078
    Abstract: Provided herein is an animal model system and uses thereof. In particular, provided herein is an animal model for Neisseria infection and use of such a model in research and screening applications.
    Type: Application
    Filed: July 19, 2019
    Publication date: January 23, 2020
    Inventors: Magdalene So, Jeffrey Frelinger, Man Cheong Ma, Daniel Powell, Katherine Rhodes, Nathan J. Weyand
  • DISCRETE SIZE AND SHAPE SPECIFIC ORGANIC NANOPARTICLES DESIGNED TO ELICIT AN IMMUNE RESPONSE
    Publication number: 20100151031
    Abstract: The presently disclosed invention is broadly directed to therapeutic micro- and/or nanoparticles designed to target an immune cell with an active agent. More particularly, the particles have a predetermined geometry and a broadest dimension of less than about 10 ?m. The immune cell-targeted micro and/or nanoparticles may additionally comprise a biocompatible polymer.
    Type: Application
    Filed: March 24, 2008
    Publication date: June 17, 2010
    Inventors: Joseph M. DeSimone, Robby Petros, Jeffrey Frelinger, Adam Buntzman
  • Identification of drugs using complementary combinatorial libraries
    Publication number: 20050069951
    Abstract: The present invention is directed to the identification of compounds in a compound library which can mediate the biological activity of a target receptor protein, even when the ligands which mediate that activity through binding to that receptor are not already known. The method of the invention includes the following three steps: (1) Screen a first combinatorial library for members binding to the target protein (TP) and hence capable of use as surrogates for the unknown ligand in steps (2) and (3). (2) Screen a second library, for compounds which inhibit the binding of one or more surrogates from step (1) to TP, and, optionally. (3) Determine whether the inhibitory compound mediates the biological activity of the said TP. The first library is composed of peptides, peptoids and/or nucleic acids, and the second is not.
    Type: Application
    Filed: September 8, 2003
    Publication date: March 31, 2005
    Inventors: Dana Fowlkes, Brian Kay, Jeffrey Frelinger, Robin Hyde-Deruyscher
  • Identification of drug complementary combinatorial libraries
    Patent number: 6617114
    Abstract: The present invention is directed to the identification of compounds in a compound library which can mediate the biological activity of a target receptor protein, even when the ligands which mediate that activity through binding to that receptor are not already known. The method of the invention includes the following three steps: (1) Screen a first combinatorial library for members binding to the target protein (TP) and hence capable of use as surrogates for the unknown ligand in steps (2) and (3). (2) Screen a second library, for compounds which inhibit the binding of one or more surrogates from step (1) to TP, and, optionally. (3) Determine whether the inhibitory compound mediates the biological activity of the said TP. The first library is composed of peptides, peptoids and/or nucleic acids, and the second is not.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: September 9, 2003
    Assignee: Karo Bio AB
    Inventors: Dana M. Fowlkes, Brian K. Kay, Jeffrey A. Frelinger, Robin Parish Hyde-Deruyscher