Abstract: Certain aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which can then be easily reconstituted at time of use without any assembly by the user. A device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, and any of the internal tissues. A device of the invention can be configured to apply a spray or a stream of liquid formulation onto a surface to be treated. A device of the invention can be configured to deliver the formulation through an endoscope or laparoscope.

Abstract: One aspect of the invention relates to an applicator system, and methods of use thereof, that can be used to house separately one or more liquids and one or more solids (e.g., components of a polymerizable hydrogel). In certain embodiments, the applicator systems are further designed to facilitate the mixing of the solids and liquids inside the applicator. In addition, in certain embodiments, the applicator systems are also designed to facilitate the application of the mixture to a surface.

Abstract: One aspect of the present invention generally relates to methods of sealing a defect, wound or void using a two component system composed of masking material, which creates an anti-adhesion barrier, and a covering material. In certain embodiment, the covering material comprises an in situ polymerizing sealant. In certain embodiments, the in situ polymerizing sealant is a hydrogel which binds to the healthy tissue but remain unadhered to the area under the masking material. In certain embodiments, the masking material is also a hydrogel. In certain embodiments, normal biological processes may dissolve away the masking material leaving a protective cover of polymerized sealant over the wound site.

Abstract: Certain aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which can then be easily reconstituted at time of use without any assembly by the user. A device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, and any of the internal tissues. A device of the invention can be configured to apply a spray or a stream of liquid formulation onto a surface to be treated. A device of the invention can be configured to deliver the formulation through an endoscope or laparoscope.

Abstract: Biocompatible polymers and adhesives have a cyanoacrylic core and other substituents such as therapeutic agents, targeting moieties, imaging agents, amino acid residues or other organic moieties. Exemplary uses of inventive compositions include use as sealants and adhesives for medical uses, and as polymeric formulations for biocompatible implants and matrices and drug delivery.

Abstract: A method of treating snoring, includes injecting least one of a monomer composition, a polymer solution and a microparticle solution into a patient's soft palate, optionally with a least one of an additional medicament, bioactive agent, sclerotic agent or stiffening agent. The injected composition, if not already polymerized prior to injection, is allowed to polymerize to form a polymer within the soft palate, thereby stiffening the soft palate, rendering it resistant to palatal flutter.

Abstract: A biocompatible monomer composition includes: (A) at least one monomer, which forms a medically acceptable polymer; (B) at least one plasticizing agent present in the composition in an amount of from 0.5 wt. to 15 wt. % of the composition; and (C) at least one acidic stabilizing agent having a pKa ionization constant of from about 1 to about 7. The composition can be applied to a variety of materials and is particularly suitable as in vivo tissue adhesive. A method of joining together in vivo two surfaces, e.g.

Abstract: An article of manufacture for dispensing an adhesive material, such as a synthetic or semi-synthetic polymerizable or cross-linkable monomer material, includes a container body, and a porous applicator tip having a proximal end that is attached to the container body, and a distal end located away from the container body, wherein the adhesive material is located in the container body in a non-contacting relationship with the applicator tip prior to dispensing the material. A flow pattern of the adhesive material within or on the applicator tip is controlled by providing one or more cuts in the applicator tip to alter flow properties of the adhesive material through the applicator tip.

Abstract: An article of manufacture for dispensing an adhesive material, such as a synthetic or semi-synthetic polymerizable or cross-linkable monomer material, includes a container body, and a porous applicator tip having a proximal end that is attached to the container body, and a distal end located away from the container body, wherein the adhesive material is located in the container body in a non-contacting relationship with the applicator tip prior to dispensing the material. A flow pattern of the adhesive material within or on the applicator tip is controlled by controlling lengths of flow paths of the material through the applicator tip, forming one or more grooves in the applicator tip, providing a hollow, controlled thickness tip, and/or adding a cover surrounding at least a part but not all of an exposed area of the applicator tip.

Abstract: A biocompatible monomer composition includes: (A) at least one monomer, which forms a medically acceptable polymer; (B) at least one plasticizing agent present in the composition in an amount of from 0.5 wt. % to 15 wt. % of the composition; and (C) at least one acidic stabilizing agent having a pKa ionization constant of from about 1 to about 7. The composition can be applied to a variety of materials and is particularly suitable as in vivo tissue adhesive. A method of joining together in vivo two surfaces, e.g.

Abstract: An article of manufacture for dispensing an adhesive material, such as a synthetic or semi-synthetic polymerizable or cross-linkable monomer material, includes a container body, and a porous applicator tip having a proximal end that is attached to the container body, and a distal end located away from the container body, wherein the adhesive material is located in the container body in a non-contacting relationship with the applicator tip prior to dispensing the material. A flow pattern of the adhesive material within or on the applicator tip is controlled by providing one or more cuts in the applicator tip to alter flow properties of the adhesive material through the applicator tip.

Abstract: An article of manufacture for dispensing an adhesive material, such as a synthetic or semi-synthetic polymerizable or cross-linkable monomer material, includes a container body, and a porous applicator tip having a proximal end that is attached to the container body, and a distal end located away from the container body, wherein the adhesive material is located in the container body in a non-contacting relationship with the applicator tip prior to dispensing the material. A flow pattern of the adhesive material within or on the applicator tip is controlled by controlling lengths of flow paths of the material through the applicator tip, forming one or more grooves in the applicator tip, providing a hollow, controlled thickness tip, and/or adding a cover surrounding at least a part but not all of an exposed area of the applicator tip.

Abstract: A method of treating snoring, includes injecting least one of a monomer composition, a polymer solution and a microparticle solution into a patient's soft palate, optionally with a least one of an additional medicament, bioactive agent, sclerotic agent or stiffening agent. The injected composition, if not already polymerized prior to injection, is allowed to polymerize to form a polymer within the soft palate, thereby stiffening the soft palate, rendering it resistant to palatal flutter.

Abstract: Achieving lung volume reduction includes occluding a lumen of a bronchial tube of a lung to prevent air flow to at least a region of the lung. Bronchial occluders such as polymerizable materials and mechanical devices, such as sutures, staples, clips, clamps, foam, balloons, umbrellas and ball bearings are provided for occluding a bronchial tube. Methods include mixing thickeners or foaming agents with polymerizable compositions and introducing the mixture into a lumen of a bronchial tube. Mechanisms for mixing components and delivering the mixture to a lumen of a bronchial tube are also provided.

Abstract: A polymerizable 1,1-disubstituted ethylene formulation applicator includes polymerizable 1,1-disubstituted ethylene monomer. According to one embodiment, the monomer is surrounded by a container that may be engaged with an applicator tip The applicator tip has an internal cavity defined in an applicator tip body. A female fitting at an open end of the applicator tip body is in fluid communication with the cavity. A porous material member is connected to the applicator tip body to be in fluid communication with the internal cavity. The applicator tip may include a valve member disposed between the internal cavity and the porous material member. Also, the applicator tip may include a piercing or breaking member disposed substantially within the internal cavity. The container of monomer includes a male fitting that may be engaged with the female fitting of the applicator tip to form the applicator.

Abstract: An article of manufacture for dispensing an adhesive material, such as a synthetic or semi-synthetic polymerizable or cross-linkable monomer material, includes a container body, and a porous applicator tip having a proximal end that is attached to the container body, and a distal end located away from the container body, wherein the adhesive material is located in the container body in a non-contacting relationship with the applicator tip prior to dispensing the material. A flow pattern of the adhesive material within or on the applicator tip is controlled by controlling lengths of flow paths of the material through the applicator tip, forming one or more grooves in the applicator tip, providing a hollow, controlled thickness tip, and/or adding a cover surrounding at least a part but not all of an exposed area of the applicator tip.

Abstract: An article of manufacture for dispensing an adhesive material, such as a synthetic or semi-synthetic polymerizable or cross-linkable monomer material, includes a container body, and a porous applicator tip having a proximal end that is attached to the container body, and a distal end located away from the container body, wherein the adhesive material is located in the container body in a non-contacting relationship with the applicator tip prior to dispensing the material. A flow pattern of the adhesive material within or on the applicator tip is controlled by providing one or more cuts in the applicator tip to alter flow properties of the adhesive material through the applicator tip.

Abstract: An applicator for dispensing adhesive material includes a container body holding the adhesive material and an applicator tip configured to permit improved control and economy in application of the adhesive.

Abstract: An article of manufacture for dispensing a liquid adhesive includes an applicator body, a liquid adhesive contained within the applicator body, a porous applicator tip attached to the applicator body and in a non-contacting relationship with the liquid adhesive, and a polymerization initiator or rate modifier loaded in or on the applicator tip, wherein the polymerization initiator or rate modifier is selected from quaternary ammonium salts and tertiary amines. The liquid adhesive can also include a phase transfer catalyst.

Abstract: The pH-modified monomer and polymer compositions are useful as biomedical and surgical adhesives, sealants, implants and bioactive agent release carriers or matrices. They comprise a monomer or polymer; and an effective amount of an acidic or basic pH modifier effective to modify the pH of an immediate in vivo environment of the composition to a pH range at which the polymer biodegrades at a different rate than at physiologic pH. The invention also relates to in vivo applications in which surfaces are joined or treated with such pH-modified biocompatible compositions.